Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Light Sensitive Compounds for Instant Determination of Organ Function

a technology of organ function and light-sensitive compounds, which is applied in the direction of group 3/13 element organic compounds, peptides, and group 5/15 element organic compounds, can solve the problems of inability to correlate single value returned several hours after sampling with other important physiologic events, inability to obtain new or repeat data, and inability to accurately predict the effect of organ function, etc., to achieve simple, efficient and effective monitoring of organ function.

Inactive Publication Date: 2007-06-21
MALLINCKRODT INC
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to novel dyes that can be used as diagnostic agents for assessing organ function and tumor status. These dyes have multiple hydrophilic moieties and absorb light in the visible and near infrared regions of the electromagnetic spectrum. The dyes can be formulated in liposomes, micelles, or other microparticles to enhance their use for physiological monitoring of many organs. The dyes inhibit aggregation and have a long blood clearance rate. The patent text also describes the structure and properties of the dyes, as well as methods for their use in diagnostic applications.

Problems solved by technology

In addition, a single value returned several hours after sampling is difficult to correlate with other important physiologic events such as blood pressure, cardiac output, state of hydration and other specific clinical events (e.g., hemorrhage, bacteremia, ventilator settings and others).
New or repeat data are equally cumbersome to obtain.
Frequently, dosing of medication is adjusted for renal function and thus can be equally as inaccurate, equally delayed, and as difficult to reassess as the values upon which they are based.
However, these markers have several undesirable properties such as the use of radioactivity or ex-vivo handling of blood and urine samples.
The main drawback of high molecular weight polypeptides is that they are immunogenic.
In addition, large polymers with narrow molecular weight distribution are difficult to prepare, especially in large quantities.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Light Sensitive Compounds for Instant Determination of Organ Function
  • Light Sensitive Compounds for Instant Determination of Organ Function
  • Light Sensitive Compounds for Instant Determination of Organ Function

Examples

Experimental program
Comparison scheme
Effect test

example 1

Synthesis of Indole Disulfonate (FIG. 1, Compound 5, Y7=SO3−: X7=H; n=1)

[0062] A mixture of 3-methyl-2-butanone (25.2 mL), and p-hydrazinobenzenesulfonic acid (15 g) in acetic acid (45 mL) was heated at 110° C. for 3 hours. After reaction, the mixture was allowed to cool to room temperature and ethyl acetate (100 mL) was added to precipitate the product, which was filtered and washed with ethyl acetate (100 mL). The intermediate compound, 2,3,3-trimethylindolenium-5-sulfonate (FIG. 1, compound 3) was obtained as a pink powder in 80% yield. A portion of compound 3 (9.2 g) in methanol (115 mL) was carefully added to a solution of KOH in isopropanol (100 mL). A yellow potassium salt of the sulfonate was obtained in 85% yield after vacuum-drying for 12 hours. A portion of the 2,3,3-trimethylindolenium-5-sulfonate potassium salt (4 g) and 1,3-propanesultone (2.1 g) was heated in dichlorobenzene (40 mL) at 110° C. for 12 hours. The mixture was allowed to cool to room temperature and the ...

example 2

Synthesis of Indole Disulfonate (FIG. 1, Compound 5 Y7=SO3−: X7=H; n=2)

[0064] This compound was prepared by the same procedure described in Example 1, except that 1,4-butanesultone was used in place of 1,3-propanesultone.

example 3

Synthesis of Benzoindole Disulfonate (FIG. 2, Compound 8, Y7, Y8=SO3−; X7=H: n=2)

[0065] This compound was prepared by the same procedure described in Example 1, except that hydrazinonaphthalenedisulfonic acid was used in place of hydrazinobenzenesulfonic acid.

[0066] Other compounds prepared by a similar method include polyhydroxyindoles such as:

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
of wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
Login to View More

Abstract

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

Description

RELATED APPLICATIONS [0001] This application is a Continuation of U.S. patent application Ser. No. 10 / 751,232 filed Jan. 2, 2004, which will issue as U.S. Pat. No. 7,175,831, which is a Continuation-In-Part of U.S. patent application Ser. No. 09 / 688,942 filed Oct. 16, 2000, now U.S. Pat. No. 6,673,334, each of which are expressly incorporated by reference herein in its entirety.FIELD OF THE INVENTION [0002] This invention relates to novel optical probes for use in physiological function monitoring, particularly indole and benzoindole compounds. BACKGROUND OF THE INVENTION [0003] Dynamic monitoring of physiological functions of patients at the bedside is highly desirable in order to minimize the risk of acute renal failure brought about by various clinical, physiological, and pathological conditions (C. A. Rabito, L. S. T. Fang, and A. C. Waltman, Renal function in patients at risk with contrast material-induced acute renal failure: Noninvasive real-time monitoring, Radiology 1993, 1...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K51/00A61K49/10A61K49/00C07K14/47C07D417/02C07D413/02C07D403/02C07F5/00C09B23/02
CPCA61K49/0032C09B23/02
Inventor ACHILEFU, SAMUELRAJAGOPALAN, RAGHAVENDORSHOW, RICHARD B.BUGAJ, JOSEPH E.JIMENEZ, HERMO N.PERIASAMY, MUTHUNADAR P.
Owner MALLINCKRODT INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com