Device and method for detecting absolute amount of blood oxygen and blood volume of local brain tissue

Abstract

The invention discloses a device and a method for detecting the absolute amount of the blood oxygen and the blood volume of local brain tissue. The device comprises an optical probe and a controller; the optical probe is used for emitting the near-infrared light to the surface of the local brain tissue to be detected and detecting the light intensity which is reflected from the surface of the local brain tissue to be detected; the controller is used for controlling the emission of the optical probe and obtaining optical signals. According to the device and the method for detecting the absolute amount of the blood oxygen and the blood volume of the local brain tissue, a multi-wavelength light source is selected, continuous waves are utilized, and accordingly the price is low, the signals are stable, the method is easy to implement, and the rapid popularization can be achieved; a common photosensitive detector is adopted and accordingly the high measurement sensitivity is ensured and the portability of the instrument is greatly improved; an absolute value of the blood oxygen and blood volume amount of the local brain tissue can be detected noninvasively, timely, rapidly and accurately and accordingly the differences between the lesion area and the normal area or the differences between patients and normal persons can be accurately reflected.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a detection device and a detection method for the absolute amount of blood oxygen and blood volume in local brain tissue. Background technique [0002] Measuring the concentration of blood oxygen saturation in brain tissue and observing its change over time will help to understand the absolute value concentration of blood oxygen saturation in brain tissue in patients with brain diseases and patients during surgery, and provide a basis for doctors' diagnosis . [0003] Compared with widely used medical detection techniques: magnetic resonance imaging (fMRI), positron emission tomography (PET), electroencephalography / time-related potential (EEG / ERP), emerging near-infrared brain function spectroscopy or imaging (NIRS / fNIRI) has the advantages of portability, low cost, high temporal resolution, and non-invasive detection. As a non-invasive optical monitoring method...

AI Technical Summary

Problems solved by technology

Among the technical invention patents for detecting oxygen in human tissue using near-infrared spectroscopy, the invention patent ZL200310113534.7 proposes a method for detecting oxygen saturation in local brain tissue of newborns stimulated by oxygen inhalation. The relative measurement of blood oxygen saturation changes under oxygen stimulation cannot be measured in absolute quantities, so it cannot reflect the difference between patients and normal people, or the difference between lesion areas and normal areas

Invention patent ZL200610112598.9 provides a detection method for the absolute amount of oxygenated and reduced hemoglobin in human tissue, which can only measure the relative amount of oxygenated and reduced hemoglobin in human tissue, and cannot provide accurate measurement of the baseline, so the absolute amount cannot be achieved. detection

For example, the M.A.McIntosh team has measured the absolute amount of oxygenated hemoglobin in brain tissue through the method of multi-distance frequency domain measurement (FDMD), but this method uses fiber optic bundles and the cost is too high

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