The invention discloses a rule-driven collaborative interactive spatial layout automatic design method. The method is combined with human intelligence, an algorithm and priori knowledge to perform spatial automatic layout design. The method comprises the following steps that firstly, computerized rule extraction, encoding and modeling are performed on a redundant and regular layout process, and then a spatial layout scheme meeting constraint conditions in a self-driven manner is generated based on a computerized rule, so that the workload of a designer is reduced, and the designer focuses on ahigh-professionality design link. Then, a man-machine collaborative interactive optimization process is adopted, and the ubiquitous defects of availability, flexibility, attractiveness and the like of an existing computerized design method are overcome. According to the invention, the spatial layout design of a miniature old-age care institution is taken as an embodiment, an online automatic layout design platform iCareDesigner is designed, and a user can access the platform at a web end, input spatial feature description, generate a spatial design scheme by one key, and perform online interactive revision and optimization.