The invention discloses a dendrobium candidum bio-cellulose mask and a manufacturing method. The dendrobium candidum bio-cellulose mask is prepared from the following components in parts by weight: 50 to 60 parts of water, 0.1 to 1 part of acrylates/vinyl isodecanoate crosspolymer, 1 to 1.5 parts of xanthan gum, 5 to 10 parts of glycerinum, 8 to 12 parts of propylene glycol, 0.05 to 0.15 part of sodium hyaluronate, 0.1 to 0.5 part of hydrolyzed sclerotium gum, 1.5 to 2.0 parts of panthenol, 1 to 10 parts of glycine betaine, 0.5 to 1 part of 1, 2-hexanediol, 0.5 to 1 part of p-hydroxy phenyl ethyl ketone, 0.1 to 0.5 part of arginine, 0.5 to 1.5 parts of composition A, 0.1 to 0.5 part of composition B, 0.5 to 1.5 parts of lactobacillus/ yerba santa fermenting product extractive, 1 to 10 parts of hydroxyethylurea, 0.1 to 1 part of PEG/PPG-14/7 dimethyl ether, 1 to 5 parts of saccharide isomerate, 1 to 10 parts of dendrobium candidum extractive, 0.1 to 0.5 part of composition C, 0.05 to 0.15 part of essence, 0.1 to 0.5 part of PEG-40 hydrogenated castor oil, and 0.1 to 0.2 part of bio-cellulose membrane material. The dendrobium candidum bio-cellulose mask provided by the invention can be used for deeply moisturizing, moistening skin and removing wrinkles, enabling loose skin to be tightened, fading away black spots, whitening skin, and effectively improving skin texture.