The invention discloses a method for preparing a large powder metallurgy TZM blank with uniform carbon and oxygen distribution, which comprises the following steps of: 1, weighing raw materials; 2, mixing powder, namely mixing the weighed four raw materials twice under vacuum or the protection of inert gas, mixing titanium hydride powder, zirconium hydride powder and carbon black powder to prepare mixed powder, adding a volatile organic solvent into the mixed powder, uniformly stirring to prepare suspension, adding the weighed molybdenum powder into the suspension for uniform mixing, and adding residual molybdenum powder for uniform mixing; 3, performing cold isostatic pressing; and 4, sintering by keeping the temperature at stages, namely adopting a vacuum sintering furnace and sintering at three stages, wherein the process comprises the following steps of: raising the temperature at the first stage, raising the temperature at the second stage, and sintering at high temperature. The preparation method has the advantages of reasonable design, simple and convenient operation, and good using effect. The carbon content in the center and on the surface of the prepared larger-size TZM blank can be controlled to be approximately consistent, and the oxygen content in the center and on the surface of the TZM blank also can be reduced to a lower level.