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Nanometer colloid particle-assembled high-strength self-repairing injectable composite colloid gel material and preparation method and application thereof

A nanoparticle, high-strength technology, applied in non-active medical preparations, non-active polymer compounds, prostheses, etc., can solve the problem of inability to accurately control drug release, weak mechanical strength, and difficult to take into account biocompatibility and biodegradability, etc., to achieve the effect of enhancing mechanical strength, high mechanical strength, and high self-healing performance

Inactive Publication Date: 2016-07-27
SHENZHEN HUA NOVA BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional self-healing polymer hydrogel materials have many insurmountable bottlenecks, including weak mechanical strength, inability to accurately control drug release, and difficulty in balancing biocompatibility and biodegradability.
These have limited its application in the field of biomedicine, especially as implantable biomaterials

Method used

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  • Nanometer colloid particle-assembled high-strength self-repairing injectable composite colloid gel material and preparation method and application thereof
  • Nanometer colloid particle-assembled high-strength self-repairing injectable composite colloid gel material and preparation method and application thereof
  • Nanometer colloid particle-assembled high-strength self-repairing injectable composite colloid gel material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) gelatin microspheres:

[0061] In this example, gelatin nanospheres were prepared by desolvation method[7,8] to obtain the appearance of gelatin nanospheres as follows figure 2 As shown in A, the particle size of the nanospheres is about 100 nm, and the surface Zeta potential of the microspheres is about +10 mV measured in a pH7 aqueous solution.

[0062] (II) Silica microspheres:

[0063] In this example, silica microspheres were prepared by the Stober method [9]. The surrounding morphology of the obtained silica microspheres is as follows: figure 2 As shown in B, the particle size of the nano-microsphere is about 80nm, and the surface Zeta potential of the microsphere is about -40mV measured in the pH7 aqueous solution.

[0064] (III) Silica / gelatin composite colloidal gel:

[0065] Gelatin and silicon dioxide particles were respectively dispersed in a certain volume of NaOH (20mM) aqueous solution, and the volume of colloidal particles in the two suspension...

Embodiment 2

[0071] Using the gelatin and silica microspheres in Example 1, the gelatin and silica microspheres are respectively dispersed in a certain volume of HCl (20mM) aqueous solution, the volume of colloidal particles accounts for the percentage of the total volume of the suspension in the two suspensions Then the gelatin of the same concentration (i.e. the volume fraction concentration) and the suspension of inorganic particles were directly mixed and stirred quickly to obtain a uniformly dispersed two-phase colloidal particle suspension. After mixing, the volume of all colloidal particles accounted for the suspension The percentage of the total volume of the liquid is 5%; the mixing ratio of the two-phase colloidal particles is the number ratio of the two-phase particles to silicon dioxide / gelatin=5. Add alkalizing agent urea and urease powder to the two-phase colloidal dispersion, wherein the concentration of urea is 50 mM, and the concentration of urease is 30 U / ml, and the gelat...

Embodiment 3

[0073] Use the gelatin and silicon dioxide microspheres in embodiment 1, and it is respectively dispersed in the NaOH (20mM) aqueous solution of certain volume with gelatin and silicon dioxide microspheres, in two kinds of suspensions, colloid particle volume accounts for suspension The percentage of total volume is 5%, obtains the colloidal particle suspension of homogeneous dispersion; Then the gelatin of identical concentration (being volume fraction concentration) and inorganic particle suspension are directly mixed and mixed rapidly, two-phase colloidal particle mixing ratio Respectively, the ratio of the number of two-phase particles to silica / gelatin=1, 5, 10, 20, 50, to obtain a colloidal suspension in which the two-phase colloidal particles are uniformly mixed, and the percentage of the volume of all colloidal particles to the total volume after mixing is still 5 %. Add acidulant gluconolactone powder to the biphasic colloidal dispersion to a final concentration of 80...

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Abstract

The invention discloses a nanometer colloid particle-assembled high-strength self-repairing injectable composite colloid gel material and a preparation method and application thereof. According to the preparation method, two-phase colloid particles with opposite electric charges are uniformly blended in an alkaline or acidic environment, an acidifying agent or alkalizing agent is added to induce the pH of the solution to recover the neutrality, electrostatic self-assembly among the two-phase colloid particles is initiated, and a uniformly-dispersed composite gel network is formed, wherein the gel is high in mechanical strength and wide in regulation and control range, the elasticity modulus of the gel can be regulated and controlled within the range of 10 Pa-100 kPa, and the self-repairing efficiency of the gel is higher than or equal to 100%. The silicon dioxide-gelatin composite colloid gel which has both the high mechanical strength and the self-repairing performance is finally and successfully prepared, and it is verified that the composite gel still can quickly recover the mechanical strength after being broken by shear force many times; in addition, the composite gel has the excellent injectable property and plasticity and can be used for an in-vitro cell culture matrix material by serving as an injectable biological material.

Description

technical field [0001] The invention relates to a high-strength, self-repairable, injectable composite colloid gel material assembled from micron or nano particles, a preparation method and application thereof; it belongs to the fields of material science, nanomaterials and biomedical engineering. Background technique [0002] Colloidal gel is a colloidal dispersion with continuous network structure assembled from colloidal particles, and is widely used in the fields of ceramic / glass processing, paint and coating preparation, food processing, cosmetic processing and biomedical engineering. Different from the traditional polymer gel, the colloidal gel structure is more unique, and it builds a colloidal particle network structure with stable mechanical properties through the non-covalent bond interaction between colloidal particles. This special microstructure endows the colloidal gel with unique viscoelastic properties, which has a wide range of application values. Colloidal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/42A61K47/04A61L27/38A61L27/44A61L27/46A61L27/52
CPCA61K9/0024A61K9/06A61K47/02A61K47/42A61L27/025A61L27/12A61L27/222A61L27/38A61L27/3804A61L27/446A61L27/46A61L27/50A61L27/52A61L2400/06
Inventor 王华楠
Owner SHENZHEN HUA NOVA BIOTECH LTD
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