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Composite material for tooth hard tissue remineralization

A tooth hard tissue and composite material technology, applied in dental prosthesis, drug combination, dentistry, etc., can solve the problems of sensitization, application restrictions, chronic fluorosis and other problems in the crowd, and achieve good biocompatibility and low Sensitization, good inhibitory effect, ideal effect of use

Active Publication Date: 2014-03-26
STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional remineralization agents have certain limitations
For example: the application of traditional fluorine preparations in high-fluorine areas can easily cause chronic fluorosis; or the components in some remineralized biomaterials are relatively poor in biocompatibility, which may cause adverse reactions to the human body or cause toxicity to certain groups of people. sensitivity, thus limiting its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh according to weight percentage: 98.95 grams of deionized water, 0.79 grams of NaCl, 0.035 grams of NaHCO 3 , 0.022 g KCl, 0.017 g K 2 HPO 4 , 0.099 grams of CMC, 0.030 grams of MgCl 2 , 0.048 g CaCl 2 and 0.007 g Na 2 SO 4 , add each reagent to the deionized water according to the above order in turn, use a magnetic stirrer at room temperature to fully mix, adjust the pH value to 7.0 to 7.2, and obtain the dental hard tissue remineralization composite material of the present invention, that is, dental use Remineralization solution 100ml.

Embodiment 2

[0015] First, add 0.01% sorbitol (sweetener) to the 100ml remineralization solution obtained in Example 1, stir and dissolve to form a uniformly dispersed remineralization solution containing sorbitol;

[0016] Get 25ml concentration again and be 5% alcohol, add the peppermint essence that is 0.1% by weight in this alcohol, stir to form the alcoholic solution that evenly contains peppermint essence;

[0017] Then, in a stirring state, the remineralization solution containing sorbitol and the alcohol solution containing mint essence are mixed, after mixing evenly, stand for a day and night, and then filter and aseptically process to obtain 125 ml of mouthwash.

[0018] Rinsing with this mouthwash promotes the remineralization of the tooth enamel surface.

Embodiment 3

[0020] Use the CMC-containing remineralization solution in Example 1 to soak the enamel slices inoculated with the activated Streptococcus mutans bacterial liquid, and carry out anaerobic culture to the enamel slices at 37°C. Scanning electron microscope observations were carried out at 8 days, and it was found that with the extension of culture time, the adhesion morphology of plaque biofilm bacteria changed significantly, and the number of bacteria decreased significantly, which confirmed that CMC had an inhibitory effect on Streptococcus mutans.

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Abstract

The invention provides a composite material for tooth hard tissue remineralization. The composite material comprises a simulation body fluid, and is improved in that the simulation body fluid is added with 0.1+ / -0.001% by weight of carboxymethyl chitosan and 0.025+ / -0.005% by weight of an amorphous calcium phosphate component. According to the present invention, after using the composite material, the remineralization effect can be provided for the demineralized tooth tissue, characteristics of no toxicity, no irritating, good biocompatibility and low allergenicity are provided, good inhibition effects are provided for oral cariogenic bacteria such as Streptococcus mutans, and the use effect is good.

Description

technical field [0001] The present invention relates to a biological material for remineralizing demineralized tooth hard tissue, in particular to a tooth hard tissue remineralization with good antibacterial properties, good biocompatibility and a wide range of applicable people of composite materials. Background technique [0002] At present, common remineralization preparations mainly use mineral ions such as calcium and phosphate as active ingredients, supplemented by fluoride ions or other substances, so as to achieve the purpose of mineral reconstruction on the residual crystals in the lower layer of demineralized caries. However, traditional remineralization agents have certain limitations. For example: the application of traditional fluorine preparations in high-fluorine areas can easily cause chronic fluorosis; or the components in some remineralized biomaterials are relatively poor in biocompatibility, which may cause adverse reactions to the human body or cause to...

Claims

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Application Information

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IPC IPC(8): A61K6/097A61K6/033A61K8/97A61K8/73A61K8/24A61Q11/00A61P1/02A61P31/02A61K6/838A61K6/898
Inventor 张旭李彦秋孙晓曦宋秀环
Owner STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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