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A remineralization material for demineralized tooth enamel surface and preparation method thereof

A technology of remineralization and enamel, applied in the direction of dental preparations, dentistry, dental prosthesis, etc., to achieve the effects of reasonable structural design, low sensitization, and simple preparation method

Active Publication Date: 2019-01-22
STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of this, the present invention aims to propose a remineralization material for the surface of demineralized tooth enamel and a preparation method thereof, to overcome the shortcomings of existing mineralized materials, which can rapidly remineralize the surface of demineralized tooth enamel and make the Orientation and orderly arrangement of remineralized crystals

Method used

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  • A remineralization material for demineralized tooth enamel surface and preparation method thereof
  • A remineralization material for demineralized tooth enamel surface and preparation method thereof
  • A remineralization material for demineralized tooth enamel surface and preparation method thereof

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Embodiment 1

[0030] A remineralization material for the surface of demineralized tooth enamel, prepared by the following steps,

[0031] (1) Synthesis of carboxymethyl chitosan-amorphous calcium phosphate polymer

[0032] Under the sufficient stirring of room temperature and magnetic stirrer, add carboxymethyl chitosan 200mg to 30ml deionized water, after being completely dissolved, dipotassium hydrogen phosphate 47.04mg, react 15min, obtain A solution; With sufficient stirring, add 94.08mg of calcium chloride dihydrate to 10ml of deionized water to form liquid B;

[0033] Under normal temperature and sufficient stirring with a magnetic stirrer, liquid B is added dropwise to liquid A to form a mixed solution of carboxymethyl chitosan-amorphous calcium phosphate (CMC-ACP); the formed carboxymethyl chitosan - The average particle size of the amorphous calcium phosphate nanocomposite is 50-200 nm.

[0034] (2) Formation of mineralized materials

[0035] Under normal temperature and suffici...

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Abstract

The present invention provides a remineralizing material for use on a demineralized enamel surface and a preparation method thereof; the remineralizing material is prepared through the following steps: using carboxymethyl chitosan of certain concentration to stabilize hydrogen phosphate ions in supersaturated ionic solution with hydrogen phosphate and calcium ions in supersaturated calcium-containing ionic liquid, so as to form nano amorphous calcium phosphate particles, and adding sodium hypochlorite solution of certain concentration and glycine into sodium hypochlorite solution of certain concentration to obtain the remineralizing material. The demineralized enamel oriented ordered mineralizing material described herein has reasonable structural design, is simple to prepare and can transform quickly into crystal and specifically binds and firmly binds with the demineralized enamel surface; arranging newly-formed hydroxyapatite in a certain direction in order; the material is nontoxic and nonirritating, has good biocompatibility and low allergicity and has ideal result.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a remineralization material for demineralized tooth enamel surface and a preparation method thereof. Background technique [0002] At present, common remineralization preparations mainly use mineral ions such as calcium and phosphate as active ingredients, supplemented with fluoride ions or other substances, or use polyelectrolytes as stable ingredients to achieve the purpose of calcium and phosphorus stabilizers, so as to achieve the purpose of demineralization. The purpose of mineral reconstruction on the residual crystals on the surface of carious lesions, this kind of mineralization experiment has great guiding significance for the treatment of early clinical caries. However, traditional remineralization agents have certain limitations. For example: the mineralization period is long, the mineralization speed is slow, and the experimental conditions require l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/097A61K6/02A61K6/898
CPCA61K6/80A61K6/898C08L5/08
Inventor 张旭王浩荣肖作慧
Owner STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV
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