The invention relates to a seven-layer coextrusion composite high-separation packaging film which comprises polyethylene (PE) resin, ethane and vinyl alcohol copolymer (EVOH) resin, a connecting material (TIE) and polyamide (PA), each layer of the packaging film comprises one of the four kinds of resin, the thickness of the packaging film is -20-15 mu m, and the packaging film is processed by a coextrusion film blowing machine by adopting multilayer coextrusion composite technology. The seven-layer coextrusion composite high-separation packaging film has the advantages of high-separation gas tightness, environmental protection, high mechanical property, high explosion resistance, strong puncture resistance, strong tear resistance, oil resistance, moisture resistance, high-temperature cooking resistance, low-temperature refrigeration resistance, quality assurance, fresh preservation, odor preservation, low cost, good heat sealability, high flexibility and good transparency.