A kind of ultrafine colloidal powder with core and shell structure and its preparation method and application

A shell structure, ultra-fine technology, applied in the direction of microsphere preparation, microcapsule preparation, dental preparation, etc., can solve the problems of unsolved practical application cases, and achieve the advantages of industrial preparation, excellent desensitization effect, and improvement of the state of teeth Effect

Active Publication Date: 2016-12-21
CHENGDU MEDART MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are no relevant reports in the public literature, and there are no practical application cases to solve this problem.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepare ultrafine colloidal powder according to the following steps:

[0035] (1) Grinding 0.1 parts by weight of bioactive glass through a ball mill, and then sieving to obtain an ultrafine inorganic powder with an average particle size of 0.3-0.8 μm;

[0036] (2) Perform 1000r / min high-speed ultrasonic stirring on 10 parts by weight of water, the ultrasonic vibration frequency is 22KHz, and the ultrasonic intermittent time is 0.5min, and the ultrafine inorganic matter powder prepared in step (1) is evenly added to the aqueous solution to obtain Ultrafine inorganic powder suspension aqueous solution;

[0037] (3) Add 10 parts by weight of sodium alginate to 30 parts by weight of water, and stir through high-speed ultrasonic stirring at 1000r / min, the ultrasonic vibration frequency is 22KHz, the ultrasonic intermittent time is 0.5min, and the ultrasonic stirring time is 0.5h. colloidal aqueous solution;

[0038] (4) 100 parts by weight of the colloidal aqueous solutio...

Embodiment 2

[0044] Prepare ultrafine colloidal powder according to the following steps:

[0045] (1) Grinding 5 parts by weight of hydroxyapatite through a ball mill, and then sieving to obtain an ultrafine inorganic powder with an average particle size of 0.3-0.8 μm;

[0046] (2) Perform 2000r / min high-speed ultrasonic stirring on 30 parts by weight of water, the ultrasonic vibration frequency is 23KHz, and the ultrasonic intermittent time is 3min, and the ultrafine inorganic matter powder prepared in step (1) is evenly added to the aqueous solution to obtain super Micro-inorganic powder suspension aqueous solution;

[0047] (3) Add 30 parts by weight of sodium alginate derivatives to 80 parts by weight of water, stir through high-speed ultrasonic at 1500r / min, the frequency of ultrasonic vibration is 23KHz, the interval time of ultrasonic is 3min, and the time of ultrasonic stirring is 2h. colloidal aqueous solution;

[0048] (4) 200 parts by weight of the colloidal aqueous solution p...

Embodiment 3

[0054] Prepare ultrafine colloidal powder according to the following steps:

[0055] (1) Grinding 10 parts by weight of calcium bicarbonate through a ball mill, and then sieving to obtain an ultrafine inorganic powder with an average particle size of 0.3-0.8 μm;

[0056] (2) Perform 3000r / min high-speed ultrasonic stirring on 50 parts by weight of water, the ultrasonic vibration frequency is 25KHz, and the ultrasonic intermittent time is 5min, and the ultrafine inorganic matter powder prepared in step (1) is evenly added to the aqueous solution to obtain super Micro-inorganic powder suspension aqueous solution;

[0057] (3) 50 parts by weight of gelatin was added to 200 parts by weight of water, and stirred by high-speed ultrasonic at 2000r / min, the ultrasonic vibration frequency was 25KHz, the ultrasonic intermittent time was 5min, and the ultrasonic stirring time was 5h, to obtain a colloidal aqueous solution;

[0058] (4) 500 parts by weight of the colloidal aqueous soluti...

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Abstract

The invention discloses ultra-micro colloidal powder with a core-shell structure. The diameters of the ultra-micro particles are 0.01 to 10 microns, each ultra-micro particle comprises a core and a spherical shell, the core is an inorganic substance, the spherical shell is colloid, and the spherical shell is made of a cross linker though curing. The invention also discloses a preparation method of the ultra-micro colloidal powder. The preparation method comprises the following steps of: preparing ultra-micro inorganic substance powder; adding water to prepare a suspended aqueous solution of the ultra-micro inorganic substance powder; preparing a colloidal aqueous solution; preparing colloid-inorganic substance emulsion by mixing; adding the cross linker to prepare cross-linked colloid-inorganic substance emulsion; adding methanol or ethanol, and performing chromatography on ultra-micro colloidal micro-spherical particles; and washing again and again and then carrying out vacuum filtration, drying, thus obtaining the ultra-micro colloidal powder. The invention also discloses application of the ultra-micro colloidal powder used as an oral preparation additive. The ultra-micro colloidal powder has the effect of the inorganic substance, and does not damage a contact object due to the spherical shell.

Description

technical field [0001] The invention relates to an ultrafine powder and its preparation method and application, in particular to an ultrafine colloidal powder with a core-shell structure and its preparation method and application. Background technique [0002] Ultrafine powder is often used as an additive in some preparations, and is jointly made into liquid or paste. When these liquids or pastes are applied to the local part of the organism, because the shape of the ultrafine particles of the ultrafine powder is irregular and angular, it may cause damage to the organism, which will cause new problems and seriously restrict its application. limit. The toothpaste product is taken as an example for specific description below: [0003] According to the epidemiological survey data released by the Chinese Stomatological Association, 29.7% of adults aged 20-60 in my country suffer from dentin sensitivity every day. This means that almost one-third of the population in China suf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/19A61K8/24A61K8/11A61K6/027A61K6/033C08J3/28C08J3/24B01J13/02A61Q11/00A61K6/838
Inventor 张晓金
Owner CHENGDU MEDART MEDICAL SCI CO LTD
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