The invention relates to a composite type artificial
dura mater, comprising two hydrogel
layers and a woven layer, wherein the woven layer is arranged between the two hydrogel
layers, the woven layer is a degradable
polymer material, and
cell growth factors are contained in the hydrogel
layers. The composite type artificial
dura mater disclosed by the invention has the following beneficial effects: (1) the artificial
dura mater is made from the degradable
polymer material and biological
protein which are easily available, and has good
biocompatibility; (2)
atmospheric pressure plasma jet treatment increases the
fiber surface area of the woven layer, decreases a
contact angle of a material surface, and improves water transmissibility, degradation speed and cellular affinity; (3) regulation on physical characteristics of the artificial dura mater, such as malleability,
toughness,
mechanical strength and the like can be realized by regulating a weaving method; and 4) the composite type artificial dura mater is favorable for wound repair, and silver ions enable
artificial skin to have good antibacterial performance, so that toxic and side effects on a
human body due to the use of a chemical antibacterial
medicine are avoided, and storage life of the
artificial skin is prolonged.