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Preparation technique of 3-fluorine -5 bromine benzotrifluoride

A technology of bromotrifluorotoluene and preparation process, which is applied in the field of 3-fluoro-5-bromotrifluorotoluene preparation technology, can solve the problems of complex process, high cost, can not meet the needs of new drug development and production, etc., and achieves reasonable and advanced technology , the effect of easy industrial manufacturing

Inactive Publication Date: 2008-04-09
高邮市光明化工厂
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Problems solved by technology

The existing drug intermediates cannot meet the development and production needs of new drugs, and there are complex processes and high costs

Method used

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  • Preparation technique of 3-fluorine -5 bromine benzotrifluoride
  • Preparation technique of 3-fluorine -5 bromine benzotrifluoride
  • Preparation technique of 3-fluorine -5 bromine benzotrifluoride

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Embodiment Construction

[0009] The present invention is further described in conjunction with the examples. The process of the present invention uses 4-fluoro-6-nitrobenzotrifluoride as the initial raw material, and then undergoes reduction, bromination, and deamination in order to prepare 3-fluoro-5-bromobenzotrifluoride.

[0010] Reduction: Put 250 grams of iron powder, add 600 milliliters of water and 6 milliliters of acetic acid, heat up and reflux for 30 minutes, add 209 grams (1 mole) of 4-fluoro-6-nitrobenzotrifluoride dropwise at 90-95 degrees, and raise the temperature after dripping Reflux for 2 hours, and the sampling content reaches more than 99% for steaming. 160 g of finished product (2-trifluoromethyl-4-fluoroaniline) was obtained with a yield of 89.4%. The content is 99.45%. Reaction formula:

[0011]

[0012] Bromination: put in 18 grams of 2-trifluoromethyl-4-fluoroaniline material, 115 grams of acetic acid and 28.8 grams of acetic anhydride, add 18 grams of bromine dropwise, c...

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Abstract

The invention discloses a technique of preparing 3-fluorin-5-bromobenzotrifluoride which is an intermediate for novel medicine, belonging to the technical field of fine chemicals intermediate. The technique of preparing 3-fluorin-5-bromobenzotrifluoride takes 4-fluorin-6-nitrobenzotrifluoride as the initial material,and the 3-fluorin-5-bromobenzotrifluoride is prepared by reduction, bromination and deamination in sequence. The invention has reasonable and advanced technology, each involving reaction is regular unit reaction, and the 3-fluorin-5-bromobenzotrifluoride is an intermediate for the novel medicine; besides, the invention is easy in industrial production and ensures high yield.

Description

technical field [0001] The invention relates to a process for preparing 3-fluoro-5-bromobenzotrifluoride. 3-fluoro-5-bromobenzotrifluoride is an intermediate used for preparing novel medicines and belongs to the technical field of fine chemical intermediates. Background technique [0002] With the development of medical science, the development and production of new drugs require corresponding drug intermediates. Existing pharmaceutical intermediates cannot meet the needs of the development and production of new drugs, and there are complex processes and high costs. Therefore, the development of new drug intermediates is very important for the development of new drug research, development and production. Contents of the invention [0003] The purpose of the present invention is exactly to adapt to the development of medical science, satisfy the research and development of novel drug and the needs of production drug intermediate, provide a kind of 3-fluoro-5-bromobenzotrif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C25/13C07C17/12
Inventor 袁庚任建伟
Owner 高邮市光明化工厂
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