The invention belongs to the field of blood vessel endoscopic imaging and discloses a device and method for endovascular optical coherence tomography - opto-acoustic - ultrasonic multimode imaging. The device comprises a computer, an optical coherence tomography (OCT) excitation and collection system, an opto-acoustic signal excitation and collection system, an ultrasonic signal excitation and collection system and an integrated probe. The OCT excitation and collection system comprises a field programmable logic array (PFGA) panel, a superluminescent diode, an isolator, a first optical fiber coupler, a reference arm, a linear array charge coupled device (CCD) and a first collecting card. The opto-acoustic signal excitation and collection system comprises a pulsed laser, a diaphragm, a second optical fiber coupler and a doubly clad optical fiber. The ultrasonic signal excitation and collection system comprises a pulse ultrasonic emitter/receiver, a signal amplifier, a signal filter and a second collecting card. The OCT, opto-acoustic and ultrasonic tri-modal blood vessel endoscopic imaging system integrates three imaging modes and respective advantages thereof, and multi-parameter physiological function information and multiscale structural information of a blood vessel can be obtained.