Self-etch amphiphilic dental adhesive and preparation method thereof

An adhesive and amphiphilic technology, used in dental preparations, dentistry, dental prostheses, etc., can solve the problems of difficult infiltration of adhesives, poor bonding effect, poor bonding strength effect, etc., and achieve high bonding. Strength, good bonding effect

Inactive Publication Date: 2014-03-12
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the self-etching adhesive has brought great convenience to the operation, its bonding effect is still not as good as that of the early pre-treated adhesive with phosphoric acid, so it is necessary to further improve the adhesion of the self-etching adhesive. knot strength
The main components of the current adhesives are hydrophobic polymerizable monomers. Due to the hydrophilicity of dentin and the porous characteristics different from the surface of enamel, it is difficult for the adhesive to penetrate into the dentin tubules, resulting in adhesion. poor strength effect

Method used

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  • Self-etch amphiphilic dental adhesive and preparation method thereof
  • Self-etch amphiphilic dental adhesive and preparation method thereof
  • Self-etch amphiphilic dental adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] This embodiment relates to a self-etching amphiphilic adhesive.

[0045] 1.1. HEMA (hydroxyethyl methacrylate) surface modification of silica

[0046] Weigh a certain amount of nano-silica powder and slowly add it into the ethanol solution (ethanol: water = 19: 1, mass ratio), stir evenly, move it into a three-necked flask, and stir it quickly with a magnetic stirrer. After the dispersion is complete, drop Add 12% silane coupling agent APTES (3-aminopropyltriethoxysilane), after the dropwise addition, gradually raise the temperature to 110°C, reflux with a condenser tube, continue stirring for 3h, and after cooling down to room temperature, use Ethanol and water were subjected to several centrifugal washings and dried to obtain amino-modified silica a.

[0047] Add HEMA to 50mL dimethyl sulfoxide (DMSO), the molar ratio of HEMA to APTES is 1:1, after complete dissolution, add NHS (N-hydroxysuccinimide) and EDC (1- Ethyl-3-(3-dimethylaminopropyl)-carbodiimide) and TEA ...

Embodiment 2

[0052] This embodiment relates to a self-etching amphiphilic adhesive. It is prepared as follows:

[0053] According to the ratio of 1.5, Bis-GMA (bisphenol A diglycidyl methacrylate) was dissolved in TEGDMA (triethylene glycol dimethacrylate) at 60°C, and stirred for more than 30 minutes to make it uniform Solution, cool the solution, and then mix HEMA (dihydroxyethyl methacrylate) and MEP (di[2-(methacryloyloxy) ethyl] phosphate) according to the ratio of 2:95 and 3:95 respectively Join in the above solution, stir, then add photoinitiator CQ (camphorquinone) by 0.4% of the total mass of each monomer mixed solution above, add DMAMA (2 -(dimethylamino)ethyl methacrylate), add BHT (2,6-di-tert-butyl-4-methylphenol) according to 0.1% of the total mass of the above monomer mixed solution, stir evenly, and then Add the HEMA-modified silica obtained in Example 1 according to 10% of the total mass of the above monomer mixed solution, stir for 6 hours, make it mix evenly, keep away...

Embodiment 3

[0055] This embodiment relates to a self-etching amphiphilic adhesive.

[0056] 3.1. Acrylic anhydride modification of POSS (octapolycage silsesquioxane)

[0057] Get a certain amount of amino-modified POSS, put into a four-necked flask equipped with a reflux condenser, add 8 times its molar amount of acrylic anhydride to it, then add the solvent of triethylamine and dimethylformamide to it, then in N 2 Under protection, the product was obtained after heating and stirring at 80°C for 24 hours, and then the product was dispersed in ether, centrifuged for 6 times, placed in a vacuum oven, and dried at room temperature for 24 hours to obtain acrylamide-modified POSS.

[0058] 3.2. Preparation of self-etching amphiphilic binder

[0059] According to the ratio of 1.5, Bis-GMA (bisphenol A diglycidyl methacrylate) was dissolved in TEGDMA (triethylene glycol dimethacrylate) at 60°C, and stirred for more than 30 minutes to make it uniform Solution, cool the solution, and then mix H...

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Abstract

The invention discloses a self-etch amphiphilic dental adhesive and a preparation method thereof. The adhesive is a one-component adhesive and comprises the following components in parts by weight: 100 parts of polymerizable monomer, 0.2 to 0.8 part of photoinitiator, 0.1 to 0.5 parts of an accelerating agent, 0.001 to 0.5 parts of a polymerization inhibitor and 1 to 20 parts of filler; the polymerizable monomer comprises the following components in weight percent: 40% to 60% of resinous monomer, 1% to 10% of amphiphilic monomer, 2% to 10% of acidic monomer and 35% to 50% of dilute monomer. The self-etch amphiphilic dental adhesive provided by the invention can be used for acid etching of dentin, has the characteristic of amphipathicity, and is relatively high in bonding strenth; not only does the development of the adhesive update the conventional clinical adhesive, but also the adhesive has a relatively good dentin bonding effect.

Description

technical field [0001] The invention relates to the technical field of preparation of nanometer materials and composite materials thereof, in particular to a self-etching amphiphilic dental adhesive and a preparation method thereof. Background technique [0002] The materials used to fill and repair tooth defects and dental caries are commonly used clinically to light-cure composite resins. The composite resin is usually polymerized and solidified after filling the cavity, but because the material itself cannot maintain the adhesion with the teeth, it is necessary to use a dental bonding material for the composite resin, commonly known as a binder. Adhesives are often divided into enamel adhesives and dentin adhesives. At present, with the rapid development of science and technology and the improvement of people's living standards, after decades of experimental research and clinical exploration, adhesives are constantly developing in the direction of aesthetics, high bondin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/083A61K6/033A61K6/027C08F222/20C08F222/14C08F220/32C08F220/28C08F230/02C08F2/48C08K9/04C08K3/36C08K5/549A61K6/838
Inventor 周涓朱君张彬钟建金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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