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Blood state analysis device, blood state analysis system, blood state analysis method, and storage device

一种状态分析、血液的技术，应用在测量装置、分析材料、仪器等方向，能够解决浪费血液制剂和医疗费用、增大传染病风险、测量不是自动的等问题，达到方便且血液凝固能力、精确血液凝固能力的效果

Inactive Publication Date: 2016-11-30
SONY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, (1) the measurement is not automatic and the measurement results depend on the experience of the measurement personnel, (2) the measurement may be subject to the influence of vibration, (3) the quality control (QC) procedure is complicated and the reagents for QC are expensive, and (4) Requires a skilled technician to interpret the output signal (thromboelastogram, thromboelastogram), which is seen as the main reason for not achieving its widespread use
Therefore, for patients who do not need blood transfusion, blood preparations are currently empirically used as a preventive measure if a comprehensive coagulation test is performed, which not only increases the risk of infectious diseases, but also wastes blood preparations and medical expenses

Method used

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  • Blood state analysis device, blood state analysis system, blood state analysis method, and storage device
  • Blood state analysis device, blood state analysis system, blood state analysis method, and storage device
  • Blood state analysis device, blood state analysis system, blood state analysis method, and storage device

Examples

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Effect test

example 1

[0166] Hereinafter, the present technology is described in more detail based on examples. The examples described below show illustrative examples of the present technology so as not to interpret the scope of the present technology in a narrow sense.

[0167] In Example 1, the correlation between the parameter of blood coagulation ability obtained from the electrical characteristics of the blood sample and the hematocrit value was examined. In this example, the dielectric constant is used as an example of the electrical properties of the blood sample.

[0168]

[0169] (1) Prepare the hematocrit value of the blood sample

[0170] Venous blood from able-bodied persons was collected using vacuum blood collection tubes (amount of collected blood: 1.8 mL, 6 tubes) containing citric acid. The first tube was discarded without use, and for the remaining 5 tubes, the red blood cells were pelleted to the lower part of the blood collection tube by centrifugation (300 g'10 min) under ...

example 2

[0178] In Example 2, the correlation between the parameter of blood coagulation ability obtained from the electrical characteristics of the blood sample and the concentration of the drug to be increased in plasma was examined. In this example, the dielectric constant is used as an example of an electrical property of a blood sample.

[0179]

[0180] (1) Measurement of electrical characteristics

[0181]Venous blood from able-bodied persons was collected using vacuum blood collection tubes containing citric acid (amount of collected blood: 1.8 mL, 6 tubes). Discard the first tube without using it, and keep the remaining 5 tubes at 37 °C in advance, and add 12 mL per 180 mL of blood immediately before starting the measurement by changing its concentration in the range from 100 mM to 400 mM calcium chloride solution to start the blood clotting reaction. The dielectric constant of each blood sample was measured at a temperature of 37° C. in a frequency band of 10 MHz.

[018...

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Abstract

A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood samlple comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample.For instance, such device (1) allows to correct blood clotting time resutls with respect to concentrations of an anti-coagulant drug present in the blood sample.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of a prior Japanese patent application JP2014-085511 filed on Apr. 17, 2014, the entire contents of which are hereby incorporated by reference. technical field [0003] The technology relates to a blood state analysis device. Specifically, the present technology relates to a device that, upon adding at least one agent selected from the group consisting of an anticoagulant therapeutic release agent, a coagulation activator, an anticoagulant, a platelet activator, and an antiplatelet agent, to a blood sample Analyzing the state of blood samples while in the process; a blood state analysis system, a blood state analysis method and a program for enabling a computer to realize the method. Background technique [0004] As a method of obtaining the volume fraction of cells in a cell suspension, it is known to use low-frequency conductivity of the suspension (frequency of 100 kHz or less) a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/49
CPCG01N33/4905G01N33/491G01N33/86
Inventor 林义人马克-奥雷勒·布兰町田贤三
Owner SONY CORP
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