A kit for predicting stent restenosis after tips in patients with liver cirrhosis

A stent restenosis and kit technology, applied in the field of medicine and biology, can solve problems such as stenosis, and achieve the effects of high consistency, good calibration and high consistency

Active Publication Date: 2022-06-07
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, up to now, nomogram model for predicting the prognosis of stent restenosis after TIPS in patients with liver cirrhosis has not been established at home and abroad.

Method used

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  • A kit for predicting stent restenosis after tips in patients with liver cirrhosis
  • A kit for predicting stent restenosis after tips in patients with liver cirrhosis
  • A kit for predicting stent restenosis after tips in patients with liver cirrhosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1: Sample collection and sample processing

[0069] (1) A total of 355 patients with hepatitis B cirrhosis who received TIPS treatment in the First Affiliated Hospital of Zhengzhou University from January 2012 to January 2020 were included. Inclusion criteria: 1) patients with clinically definite diagnosis of hepatitis B cirrhosis; 2) combined with portal hypertension; 3) received TIPS surgery; 4) TIPS stents were a single Viatorr stent or bare stent combined with Fluency stent. Exclusion criteria: 1) liver cirrhosis caused by other viral hepatitis, autoimmunity, alcohol and other causes; 2) patients with malignant tumors in the liver and other parts; 3) with cavernous degeneration of portal vein; 4) with other severe systemic diseases Diseases (organ failure, serious infection, cardiovascular and cerebrovascular diseases, etc.); 5) Those with less than 1 year follow-up or incomplete disease data.

[0070] (2) Collect the demographic data (sex, age, diabetes me...

Embodiment 2

[0074] Example 2: Screening of independent factors associated with stent restenosis after TIPS in patients with liver cirrhosis

[0075] (1) Univariate Logistic regression analysis was used to analyze the independent factors that may be associated with stent restenosis after TIPS in patients with liver cirrhosis:

[0076] In the modeling group, SPSS 21.0 statistical software was used to conduct univariate Logistic regression analysis on clinical factors that may be associated with stent restenosis after TIPS in patients with liver cirrhosis. predicted value.

[0077] Univariate Logistic regression analysis showed that the risk factors associated with stent restenosis after TIPS were: age, diabetes, portal vein thrombosis, history of splenectomy, platelet count, INR, portal vein puncture location and stent location (p 0.05) (see Table 1 for the results of univariate Logistic regression analysis).

[0078] Table 1 Univariate Logistic regression analysis of stent restenosis afte...

Embodiment 3

[0085] Example 3: Establishment of a prediction model for stent restenosis after TIPS in patients with liver cirrhosis

[0086] The independent factors associated with stent restenosis after TIPS in patients with liver cirrhosis obtained by multivariate Logistic regression analysis were assigned, and the assignments are shown in Table 3.

[0087] Table 3 Assignment of independent prognostic factors associated with stent restenosis after TIPS in patients with cirrhosis

[0088] variable assign TIPS stent position and shape Good = 0, Bad = 1 Portal vein puncture site Left branch = 0, right branch = 1 history of splenectomy no = 0, yes = 1 diabetes no = 0, yes = 1

[0089] According to the results of multivariate Logistic regression analysis, the risk function expression of each factor was established based on the β value of the four screened independent factors related to stent restenosis after TIPS in patients with liver cirrhosis. Th...

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Abstract

The invention belongs to the field of medical biotechnology, and specifically discloses a kit for predicting stent restenosis after TIPS in patients with liver cirrhosis. The kit includes reagents for detecting the position and shape of the TIPS stent, the position of portal vein puncture, the history of splenectomy, and diabetes and / or instruments. The kit of the present invention can predict the probability of stent restenosis 1 year after TIPS in patients with cirrhosis according to whether there is a history of splenectomy, diabetes, portal vein puncture position during TIPS, and stent position after TIPS in patients with cirrhosis. It helps clinicians to formulate individualized postoperative review or follow-up plans according to the expected probability of stent restenosis.

Description

technical field [0001] The invention belongs to the field of medical biotechnology, and particularly relates to a kit for predicting stent restenosis after TIPS in patients with liver cirrhosis. Background technique [0002] Liver cirrhosis is the most common and major cause of portal hypertension, and portal hypertension is almost inevitable in patients with liver cirrhosis. Portal hypertension can cause a series of serious clinical symptoms, such as esophagogastric variceal bleeding (EGVB), refractory pleural and ascites, etc. The mortality rate of 6 weeks after EGVB can reach 20%. If no effective measures to prevent rebleeding are taken after the first EGVB, the rebleeding rate within 1 year can be as high as 60%, and the mortality rate is about 33%. The principle of transjugular intrahepatic portosystemic shunt (TIPS) is to establish a shunting channel between the intrahepatic hepatic vein and the portal vein and its main branches, so that part of the portal blood flow ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B50/30A61B5/00G16H50/50
CPCA61B50/30A61B5/7271A61B5/7275G16H50/50
Inventor 李臻詹鹏超张玉元李鑫王彩鸿吴阳李林谢滢滢吕培杰纪坤石洋叶书文谢炳灿
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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