32 results about "Renal vessels" patented technology

A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.

Methods and apparatus for treating hypertension and other vessel dilation conditions provide for delivering acoustic energy to a vascular nerve to remodel the tissue and nerves surrounding the vessel. In the case of treating hypertension, a catheter carrying an ultrasonic or other transducer is introduced to the renal vessel, and acoustic energy is delivered to the tissue containing nerves to remodel the tissue and remodulate the nerves.

A method for denervation comprises introducing a distal portion of a catheter through an interior of a vessel of a patient to a location at or proximate one of a renal pelvis or a calyx. The catheter includes an elongated catheter body extending longitudinally between a proximal end and a distal end. The catheter body includes the distal portion at the distal end and a catheter lumen from the proximal end to the distal end. Energy is delivered from the distal portion to cause renal denervation, for example, by denervating at least some tissue proximate at least one of the renal pelvis or a renal vessel from a location at or proximate the renal pelvis or the calyx from a location at or proximate the calyx.

The invention discloses a method for culture of urine-derived pluripotent stem cells by virtue of in vitro small molecule induction. The method comprises the following steps: obtaining urine-derived cells from a human urine sample; carrying out in vitro small molecule induction and culturing on the obtained primary cells to obtain P1 generation hUSCs clones growing with adherence; picking up the hUSCs clones in good growing state to inoculate; and continuously carrying out continuous cell culture to obtain hUSCs with the cells which are elongated and good in state. The hUSCs prepared by the method disclosed by the invention, by virtue of induction, can be directionally differentiated to osteoblasts, adipose cells, skeletal muscle cells, nerve cells, fibroblasts or smooth muscle cells. The hUSCs are transplanted into a diabetic lower extremity ischemia model, and research results show that the hUSCs can remarkably enhance blood flow recovery and angiogenesis in an ischemia part. The hUSCs prepared by the method can be applied to treating and repairing diseased tissues and organs of diabetes and diabetic complications, cardiovascular, cerebrovascular and renovascular diseases, Alzheimer's disease, osteoporosis, arthritis and the like as well as early-warning tumors of the urinary system and screening cell drugs.

The invention is directed to nonpeptide substituted benzodiazepines of Formula I,

wherein A, X, n, R¹, R², R³, R⁴, R⁵, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

The invention relates to 2-phenyl-6-aminbcarbonyl-pyrimidinc derivatives and their use as P2Y₁₂ receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. Formula (1).

A stent includes a substantially cylindrical segment which is deployed in the renal vessel and a flared segment which is deployed in ostial and aortic regions of the vessel. The substantially cylindrical segment provides superior radial strength for maintaining dilated diameter of the renal vessel. The flared segment, which is formed by plurality of slits extending through the sidewall of the stent, expands to conform to the ostial and aortic regions of the vessel. The flared segment can be balloon dilated to enhance conformance of the flared stented segment to the ostial and aortic regions. A stent delivery system capable of delivering and deploying the substantially cylindrical segment and the flared segment is also disclosed.

The invention discloses a spiro heterocyclic ketone N-phenyl indole compound, its preparation method and application in controlling cardiovascular diseases and other medicine fields. The compound is formed by organically connecting spiro heterocycle, indole, phenyl ring and tetrazole, is an AT1 type acceptor retarding agent of angiotensin II, and can be used for preventing or treating hypertension, coronary heart disease, disease in blood vessels of heart, brain and kidney, hemicrania, pulmonary hypertension and other diseases.

The invention relates to a 6'-substituted benzimidazole-4-substituted methylindole derivative and preparation and application thereof. A structural formula of the 6'-substituted benzimidazole-4-substituted methylindole derivative is shown as the accompanying drawing. Benzoxazole and oxazolo pyridine groups are introduced in a site 6 of benzimidazole; then, 4-substituted indole is used for replacing phenyl groups in an iosartan medicine biphenyl structure; the design and the synthesis are performed by finding the optimum bond length through increasing or decreasing the length of a carbon chain on a site 2 of the benzimidazole. The invention also provides application of the 6'-substituted benzimidazole-4-substituted methylindole derivative to the preparation of medicine for preventing and treating hypertension, coronary heart diseases, heart brain and kidney blood vessel diseases, migraine and pulmonary arterial hypertension diseases.

The invention discloses 6-pyridin benzimidazole indole derivatives and a preparation method thereof. The compounds are novel angiotensin II receptor antagonists and can be used for prevention and treatment of cardiovascular, cerebrovascular and renal-vascular diseases like hypertension, coronary heart disease and pulmonary arterial hypertension.

This invention relates to a kind of amino acid diphenyl compound and its medicine application. This compound is organically joined up by diphenyl and amino acid oxadiazole, is receptor blocking agent of angiotensin ii, could be used in preparing drug that prevent or treatment hypertension, coronary heart disease, heart- brain- renal vascular disease, migraine, pulmonary hypertension and so on.

The invention discloses a novel phenylaniline compound which is formed by organically connecting biphenyl with amino acid and oxadiazole and is the 1-type receptor antagonist of a novel hypertension II. The compound can be used for preparing medicines for preventing or treating diseases, such as high blood pressure, coronary heart disease, cardio-cerebral renovascular disease, splitting headache,splitting headache, and the like and can be used for effectively inhibiting the multiplication and the mobility of carcinomas in situ, such as gastric cancer, pancreatic cancer, oophoroma, prostatic cancer, lung cancer, bladder cancer, liver cancer, renal carcinoma, breast cancer, cervical carcinoma, colon carcinoma, and the like.

The invention relates to application of miR-668-3p as a renal fibrosis noninvasive diagnosis marker and application of the miR-668-3p as renovascular hypertension diagnosis marker, and also relates toa kit for diagnosing renal fibrosis. The kit comprises a detection reagent for detecting the expression quantity of the miR-668-3p. By using the expression quantity of the miR-668-3p in peripheral blood as a molecular marker, renovascular hypertension and renal fibrosis injury caused by the renovascular hypertension can be noninvasively detected, besides, the lesion process of the renovascular hypertension and renal fibrosis injury can be noninvasively and dynamically monitored, and the miR-668-3p has important clinical application value.

The invention discloses a human renal angiomyolipoma PCDX mouse model and an establishment method thereof, and belongs to the field of medical fundamental research. The human renal angiomyolipoma PCDX mouse model is obtained by subcutaneously inoculating human renal angiomyolipoma primary cells on the shoulder and back of the forelimb of a mouse and then culturing; and the human renal angiomyolipoma primary cells have been preserved in China Center for Type Culture Collection in advance. The establishment method of the mouse model comprises the following steps: taking the human renal angiomyolipoma primary cells, and conducting culturing, proliferating and digesting to obtain a sufficient primary cell suspension; preparing a primary cell mixed solution; and inoculating the primary cell mixed solution to the subcutaneous part of the back of the forelimb of the mouse, and feeding the mouse in an SPF environment to obtain the human renal angiomyolipoma PCDX mouse model. The human renal angiomyolipoma PCDX mouse model is established for the first time, and a model foundation is laid for basic clinical research of the PCDX mouse model. The establishment method of the mouse model is high in tumor formation speed, high in tumor formation rate and low in mouse death rate; and one-time large-scale preparation and repeated modeling can be realized.

The invention relates to an application of miR-122-5p as a renal fibrosis diagnosis marker, and an application of the miR-122-5p as renal vascular hypertension. The invention also relates to a kit fordiagnosing renal fibrosis. The kit comprises a detection agent for detecting the expression quantity of miR-122-5p. By using the miR-122-5p expression quantity in the peripheral blood as a molecularmarker, noninvasive detection can be performed on renal vascular hypertension and renal fibrosis injury caused by the renal vascular hypertension, noninvasive dynamic monitoring is performed on the lesion process of the renal vascular hypertension, and important clinical application value is achieved.

The invention discloses functional coffee and a preparation method thereof. The functional coffee comprises the following raw materials: a component A: cold extraction coffee powder and organic sugar; the group B of pure natural medicinal and edible dual-purpose Chinese patent medicine extract components comprise a herba epimedii extract, a cistanche deserticola extract, a male cicada moth extract, a cordyceps militaris extract, a non-rapeseed extract, a polygonum multiflorum extract, a raspberry extract, a Cabada extract, a Carfiba extract, a morinda officinalis extract, a lithocarpus pachylepis extract, a dendrobe extract, a hippocampus extract and a cynomorium songaricum extract; the functional coffee comprises a ginseng extract, an astragalus extract, a maca extract, a rhizoma polygonati extract, a eucommia ulmoides extract, a cornu cervi pantotrichum extract, a syngnathus extract, an oyster extract, an eurycoma longifolia extract and a ganoderma lucidum extract. And the kidney blood vessel can be expanded, so that the water permeation and detoxification functions of the kidney can be improved.

The invention relates to the technical fields of imaging and processing of medical organ images, in particular to a three-dimensional printing method based on synchronous development of renal vesselsand the renal collecting system. The method comprises the following steps of a, conducting three-phase scanning on the whole body of a patient by using a CT scanner; b, conducting first-phase scanning; c, conducting second-phase scanning; d, conducting third-phase scanning; e, tracing and triggering scanning by using a CT threshold value, wherein when a CT value reaches the set threshold value, automatic scanning is triggered, the trace point is the renal artery plane descending aorta, the threshold value is 110 Hu, the scanning time is 8-10 seconds, and first to fourth levels of the renal artery are shown; f, obtaining a Dicom file; g, reconstructing the Dicom file through data processing, and obtaining a 3D organ data model; g, obtaining a file in the STL format, and printing a 3D humanorgan model through a 3D printer. According to the method, the synchronous development technology is combined with the 3D printing technology to print the 3D organ model, and an effect and practical clinical significance is provided for clinical teaching, surgery simulation and personalized medicine of the urinary surgery.

According to another general aspect, an apparatus for irradiating a plurality of renal nerves comprising a guidewire used to lead an elongated catheter in the human body; the enlongated catheter further comprising a plurality of lumens; the plurality of lumens further comprising a source train lumen, a hydraulic pump lumen, a guidewire lumen, and an inflator lumen; the elongated catheter is connected to the guidewire by inserting the guidewire into the guidewire lumen; the elongated catheter contains a source train within the source train lumen; the source train lumen and hydraulic pump lumen are used to push the source train to a renal vessel.