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Topical anti-microbial compositions

A topical composition, anti-microbial technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, medical raw materials of non-living substances, etc., can solve the problem of no biocidal effect and the like

Inactive Publication Date: 2003-04-30
THE PROCTER & GAMBLE COMPANY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, copper and zinc salts do not have as high a biocidal efficacy as is required in many anti-dandruff and skin care applications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0281] Reality Embodiment 1 Combination of ZPT and metal ions to the minimum inhibitory concentration (MIC) of metal ions influences

[0282] This experiment was performed to investigate the efficacy of the compositions of the present invention in inhibiting the survival, growth and proliferation of microorganisms when used in topical compositions. The test microorganism was Malassezia furfur. The assay principle used, the minimum inhibitory concentration (MIC) is discussed below, and the results are presented in Table 1.

[0283] Minimum inhibitory concentrations are indicative of antifungal efficacy. In general, the lower the value of the composition, the better its antifungal efficacy due to the enhanced intrinsic ability of the antidandruff agent to inhibit the growth of microorganisms.

[0284] M. furfur was grown in flasks containing mDixon medium (see, E. Gueho et al., Antoinie Leeuwenhoek (1996), no. 69, 337-55, the description of which is incorporated herein by...

Embodiment 2

[0306] The influence of embodiment 2 metal ions on the killing rate result of zinc pyrithione

[0307] This experiment was performed to investigate the efficacy of the compositions of the present invention in inhibiting the survival, growth and proliferation of microorganisms in topical compositions. The test microorganism was Maalassezia furfur. The test principle used, the Kill Rate Test (KRT), is discussed below and the results are presented in Tables 2(a) and 2(b).

[0308] The kill rate test (KRT) is a characterization of antifungal efficacy. In general, the greater the inhibition of fungal growth in this test, the better the antifungal efficacy of the compound being tested.

[0309] Flasks containing mDixon broth were inoculated with M. furfur (see, Gueho et al., Antoinie Leeuwenhoek (1996), No. 69, 337-55, the description of which is incorporated herein by reference). Then, the specified concentration of active material was added to the flask. Then, at the indicat...

Embodiment 3-26

[0343] topical composition

[0344] The compositions shown in Examples 3-26 illustrate specific embodiments of the topical antimicrobial compositions of the present invention, but are not limiting of the invention.

[0345] All exemplified compositions can be prepared by conventional formulation and mixing techniques. Component amounts are listed in weight percent and exclude minor materials such as diluents, fillers, and the like. Accordingly, the listed formulations contain the listed ingredients and any minor substances associated with such ingredients. The term "minor materials" as used herein refers to those optional materials such as preservatives, viscosity regulators, pH regulators, fragrances, foam boosters and the like. It will be apparent to those of ordinary skill in the art that the selection of these minor materials will vary with the physical and chemical characteristics selected to prepare the particular ingredients of the present invention. Other changes ...

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Abstract

Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.

Description

technical field [0001] The present invention relates to topical anti-microbial compositions and methods of treating microbial infections on the skin or scalp. Of particular interest are methods for treating dandruff and compositions providing improved antidandruff activity. In particular, the present invention relates to methods and compositions using polyvalent metal salts of pyrithione and sources of metal ions. Background of the invention [0002] Various anti-dandruff compositions are commercially available or well known in the shampoo art. These compositions generally comprise a detersive surfactant and a particulate crystalline antimicrobial agent dispersed and suspended throughout the composition. Antimicrobial agents useful for this purpose include sulfur, selenium sulfide, and polyvalent metal salts of pyrithione. During shampooing, these antimicrobial agents are deposited on the scalp to provide antidandruff activity. Soluble anti-dandr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/00A61K8/20A61K8/21A61K8/24A61K8/25A61K8/33A61K8/36A61K8/365A61K8/368A61K8/41A61K8/49A61K31/44A61K31/496A61K33/04A61K33/244A61K35/04A61P31/10A61Q5/00A61Q5/02A61Q17/00
CPCA61Q17/005A61K8/27A61K8/19A61Q5/006A61K8/4933A61P17/00A61P31/00A61P31/04A61P31/10A61P43/00A61K33/24A61K31/44A61K33/244
Inventor 戴维·F·加文安东尼·R·马凯塔约翰·D·尼尔森乔治·波尔森詹姆斯·R·施瓦茨帕特里夏·A·特利
Owner THE PROCTER & GAMBLE COMPANY
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