Oligosaccharide Aldonic Acids and Their Topical Use

a technology of oligosaccharide aldonic acid and topical use, which is applied in the field of oligosaccharide aldonic acid and their topical use, can solve the problems of not disclosing or suggesting a carbohydrate, and not disclosing or suggesting oligosaccharide aldonic acid, so as to reduce mucosa and skin erythema, reduce inflammation, and soothe the

Inactive Publication Date: 2008-04-17
YU RUEY J +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] Compositions comprising oligosaccharide aldonic acids are beneficial and effective for general care, reducing and soothing mucosa and skin erythema, inflammation or reaction caused by internal or external factors, treatment and healing of skin, hair, nail; nasal, oral and vaginal mucosa including treatment, healing and prevention of cosmetic conditions and dermatological indications as well as cosmetic and clinical signs of changes associated with intrinsic aging, or the damages caused by extrinsic factors as sunlight, radiations, air pollution, wind, cold, dampness, heat, chemicals, smoke, and cigarette smoking.

Problems solved by technology

The name comes from a carbohydrate, aldose, which may be oxidized to aldonic acid by the oxidation of the aldehyde group in aldose to the carboxylic group.” The application, however, does not disclose or suggest that a carbohydrate may be chemically linked to an aldonic acid.
Thus, this application does not disclose or suggest oligosaccharide aldonic acids.

Method used

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  • Oligosaccharide Aldonic Acids and Their Topical Use

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0116] A typical experiment to determine a gel matrix formation of an oligosaccharide aldonic acid may be carried out as follows.

[0117] Maltobionic acid 1 g in a beaker of 3.6 cm diameter and 3.6 cm height was dissolved in water 1 ml, and the solution thus obtained was left at room temperature between 20-25° C. to allow a slow evaporation of the water. Fifty percent of original water had been evaporated at the end of 24 hours, 57% at the end of 48 hours, 60% at the end of 72 hour and 60.5% at the end of 96 Hours. A clear continuous gel film was formed at the end of 72 hours, and this was confirmed by observation under a microscope and determination from its physical characteristics. The continuous transparent film thus obtained consisted of 71% maltobionic acid and 29% water by weight, and was formed as a complex gel matrix between maltobionic acid molecules and water molecules.

[0118] Under the same conditions, a clear continuous gel film was formed from lactobionic acid 1 g and w...

example 2

[0121] Antioxidant property of an oligosaccharide aldonic acid may be determined by utilizing anthralin test method as follows.

[0122] Anthralin also known as dithranol is a yellowish powder, and a composition containing anthralin without a suitable antioxidant is chemically unstable even at room temperature. For example, anthralin 0.05% in an oil-in-water cream changed in color from yellow to gray within 24 hours at room temperature, and the cream became brownish within 48 hours. Under anhydrous condition, anthralin 0.05% ointment prepared from white petrolatum 2 parts and mineral oil 1 part by weight changed in color from bright yellow to grayish yellow within 24 hours, and the ointment became brownish after 12 days at room temperature.

[0123] Based on the above observations, an oil-in-water cream containing 0.4% anthralin with or without a known antioxidant was used as a positive or vehicle control. The final concentration of a test substance or antioxidant was 0.1 M. It was foun...

example 4

[0124] Antioxidant property of an oligosaccharide aldonic acid may also be determined by utilizing banana peel test method as follows.

[0125] A fresh ripe banana peel cut into sizes of 2×2 cm has the outer layer light yellow in color. These freshly cut banana peels after exposed to air or immersed in an aqueous solution without an antioxidant in 50 mm plastic petri dishes rapidly changed in color from yellowish to tan within 3 hours, dark tan within 24 hours and brown black after 72 hours. A test substance including a positive control such as vitamin C, citric acid or N-acetylcysteine was prepared as 0.1 M concentration, and each test dish contained 5 ml test solution. Freshly cut banana peels 2×2 cm in sizes were immersed in 5 ml test solutions including known antioxidants and vehicle controls with pH at 7.0 and 4.0. It was found that while the banana peels immersed in water alone changed in color from white yellowish to tan within 4 hours, the banana peels did not change color in ...

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Abstract

Compositions comprising oligosaccharide aldonic acids are useful for general care, as well as for treatment and prevention, of various cosmetic conditions and dermatological disorders, including those associated with intrinsic and / or extrinsic aging, as well as with changes or damage caused by extrinsic factors; general care, as well as treatment and prevention of diseases and conditions, of the oral, and vaginal mucosa; for general oral care, as well as treatment and prevention of oral and gum diseases; and for wound healing of the skin. Compositions comprising oligosaccharide aldonic acids may further comprise a cosmetic, pharmaceutical or other topical agent to enhance or create synergetic effects.

Description

[0001] This application is a divisional application and claims the benefit of U.S. application Ser. No. 10 / 811,998, filed Mar. 30, 2004, which is a continuation of U.S. application Ser. No. 09 / 987,023, filed Nov. 13, 2001, now U.S. Pat. No. 6,740,327, which is a continuation of U.S. application Ser. No. 09 / 487,228, filed Jan. 19, 2000, now U.S. Pat. No. 6,335,023, which claims priority from U.S. provisional application Ser. No. 60 / 141,264, filed Jun. 30, 1999.FIELD OF THE INVENTION [0002] This application relates to compositions comprising oligosaccharide aldonic acids and related compounds, and their use for cosmetic and dermatological indications, reducing and soothing mucosa and skin erythema, inflammation or reaction caused by internal or external factors, wound healing, and care of skin, hair, nail, and oral and vaginal mucosa, including the use for changes associated with intrinsic and extrinsic aging, and changes or damage caused by extrinsic factors such as sunlight, radiati...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7004A61K31/122A61K31/198A61K31/355A61Q19/00A61P17/00A61K31/4164A61K31/60A61K31/715
CPCA61K8/0212A61Q19/08A61K8/60A61K31/122A61K31/198A61K31/355A61K31/4164A61K31/60A61K31/7004A61K31/715A61Q5/02A61Q11/00A61Q19/00A61Q19/007A61Q19/02A61K8/042A61P17/00A61P17/02A61P19/06A61P29/00A61P31/00
Inventor YU, RUEY J.VAN SCOTT, EUGENE J.
Owner YU RUEY J
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