Drug-eluting coated on surface of sacculus catheter air bag for alleviating vascular restenosis

A drug coating and balloon catheter technology, applied in the field of medical devices, can solve the problems of short time, complicated operation and implementation, high release speed and high blood drug concentration

Inactive Publication Date: 2008-09-17
天津百畅医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, with the popularization and application of coronary artery balloon angioplasty, the use of vascular stents containing radioactive substances has brought good news to patients with coronary heart disease. It is very complicated to implement, and its clinical use is limited due to the need to prevent the pollution of the environment by excreta containing radioactive substances
[0005] Later, drug-loaded stents were produced to prevent vascular restenosis. This type of drug is aimed at platelet GBIIb/IIIa receptor antagonists or anti

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: After 0.3g polyethylene glycol is dissolved in 10ml acetone, add 0.2g superoxide dismutase (SOD) and stir, after dissolving evenly and filtering, spray on the balloon catheter that is covered with 0.1g paclitaxel intermediate drug coating On the surface of the airbag, volatilize the solvent in nitrogen, and repeat the spraying several times at a rotating angle to make it evenly coated on the surface of the airbag. After volatilizing the solvent in nitrogen, dry it at room temperature under vacuum for 12 hours. Bacteria disinfection.

Embodiment 2

[0042] Embodiment 2: After 0.2g polytrimethylene carbonate and polyurethane copolymer (5 / 95 (mol / mol)) is dissolved in 10ml acetonitrile, add 0.5g lycopene, 0.01g coenzyme Q10 and 0.01g vitamin E, After stirring, dissolving evenly and filtering, dip-coat on the surface of the airbag in the balloon catheter coated with 0.1g actinomycin intermediate drug coating, volatilize the solvent in nitrogen, and repeat the dip-coating several times by rotating the angle to make it evenly coated On the surface of the airbag, evaporate the solvent in nitrogen, and then dry it at room temperature under vacuum for 12 hours. Sterilize it with ethylene oxide.

Embodiment 3

[0043] Example 3: After dissolving 0.3g of Youweixian 370 contrast agent in 10ml of ethyl acetate, add 0.3g of coenzyme Q10 and 0.01g of rapamycin and stir, dissolve evenly and filter, inject on the surface of the balloon in the balloon catheter, and Rotate the angle and repeat spraying several times to make it evenly coated on the surface of the airbag. After evaporating the solvent in nitrogen, dry it at room temperature under vacuum for 12 hours. Sterilize it with ethylene oxide.

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Abstract

The invention relates to a medical coating layer coated on the gasbag surface of a balloon pipe which can release the narrowing of blood vessel and reduce free radical damage after operation, belonging to the field of the medical instruments, which comprises 1% to 99% of medicine and 1% to 99% of medical carrier, wherein the medical comprises a single oxidation resisting medicine, or a mixture of a plurality of oxidation resisting medicines, or a mixture of a single or a plurality of oxidation resisting medicines with blood vessel narrowing resisting medicines; the medicines are evenly coated on the surface of the gasbag all together or layer by layer. The medical coating layer coated on the gasbag surface of a balloon pipe has the advantages that through local medication the damage to human cells and organizations after blood transfusion due to myocardial ischemia can be effectively released and reduced and the cardiac dysfunction can be finally cured.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug coating coated on the surface of a balloon catheter balloon for relieving blood vessel restenosis coated with antioxidant drugs. Background technique [0002] Atherosclerosis is an important disease that affects human health, and the disease that affects the coronary arteries of the heart is called coronary heart disease. Coronary heart disease often causes myocardial insufficiency, ranging from angina pectoris to myocardial infarction and even death. In 2000, ischemic heart disease accounted for 21.4% of all deaths in the United States, among which acute myocardial infarction accounted for 8%. [0003] Vascular recanalization for patients with acute myocardial infarction is an important progress in clinical medicine in recent years, because after ischemia, blood vessels can be dredged or revascularized to reperfuse myocardial tissue with blood, and in most cases, good ther...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/16A61L33/04
Inventor 刘泊志张志刚王闻宇
Owner 天津百畅医疗器械有限公司
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