Drug-eluting coated on surface of sacculus catheter air bag for alleviating vascular restenosis

Abstract

The invention relates to a medical coating layer coated on the gasbag surface of a balloon pipe which can release the narrowing of blood vessel and reduce free radical damage after operation, belonging to the field of the medical instruments, which comprises 1% to 99% of medicine and 1% to 99% of medical carrier, wherein the medical comprises a single oxidation resisting medicine, or a mixture of a plurality of oxidation resisting medicines, or a mixture of a single or a plurality of oxidation resisting medicines with blood vessel narrowing resisting medicines; the medicines are evenly coated on the surface of the gasbag all together or layer by layer. The medical coating layer coated on the gasbag surface of a balloon pipe has the advantages that through local medication the damage to human cells and organizations after blood transfusion due to myocardial ischemia can be effectively released and reduced and the cardiac dysfunction can be finally cured.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug coating coated on the surface of a balloon catheter balloon for relieving blood vessel restenosis coated with antioxidant drugs. Background technique [0002] Atherosclerosis is an important disease that affects human health, and the disease that affects the coronary arteries of the heart is called coronary heart disease. Coronary heart disease often causes myocardial insufficiency, ranging from angina pectoris to myocardial infarction and even death. In 2000, ischemic heart disease accounted for 21.4% of all deaths in the United States, among which acute myocardial infarction accounted for 8%. [0003] Vascular recanalization for patients with acute myocardial infarction is an important progress in clinical medicine in recent years, because after ischemia, blood vessels can be dredged or revascularized to reperfuse myocardial tissue with blood, and in most cases, good ther...

AI Technical Summary

Problems solved by technology

[0004] In recent years, with the popularization and application of coronary artery balloon angioplasty, the use of vascular stents containing radioactive substances has brought good news to patients with coronary heart disease. It is very complicated to implement, and its clinical use is limited due to the need to prevent the pollution of the environment by excreta containing radioactive substances

[0005] Later, drug-loaded stents were produced to prevent vascular restenosis. This type of drug is aimed at platelet GBIIb / IIIa receptor antagonists or anti-cancer drugs that affect cell division and accelerate cell apoptosis. Damage to the controlled-release layer on the surface of the stent during stabilization or surgery may result in excessively fast release in the human body, resulting in high local blood drug concentration, which brings the risk of further damage to cardiomyocytes

[0006] The method of intravenous injection of antioxidants (coenzyme Q10) has also been used clinically. Due to the short time, the local drug concentration cannot be maintained, and the curative effect is not satisfactory.