Vaginal effervescence tablet of secnidazole and its preparation

A technology of secnidazole and effervescent tablets is applied in the field of western medicine preparations to achieve the effects of improving effect, increasing concentration and improving curative effect

Inactive Publication Date: 2004-11-17
苏州赫森医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no technical reports and products of secnidazole effervescent tablets specially used for vaginal diseases in the world

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Recipe 1: 500 grams of secnidazole, 50-150 grams of tartaric acid, 80-120 grams of sodium bicarbonate, 45-60 grams of microcrystalline cellulose, 15-25 grams of low-substituted hydroxypropyl cellulose, magnesium stearate 8-12 grams, Tween 80 15-20 grams, polyvinylpyrrolidone 1-5 grams, Tween 80, polyvinylpyrrolidone are dissolved with 150ml absolute ethanol.

[0016] Recipe 2: 500 grams of secnidazole, 100 grams of tartaric acid, 100 grams of sodium bicarbonate, 50 grams of microcrystalline cellulose, 20 grams of low-substituted hydroxypropyl cellulose, 10 grams of magnesium stearate, 18 grams of Tween 80 , polyvinylpyrrolidone 3 grams, Tween 80, polyvinylpyrrolidone dissolved with 150ml absolute ethanol.

[0017] Recipe 3: 500 grams of secnidazole, 140 grams of tartaric acid, 120 grams of sodium bicarbonate, 50 grams of microcrystalline cellulose, 20 grams of low-substituted hydroxypropyl cellulose, 10 grams of magnesium stearate, 12 grams of Tween 80 , polyvinylpyrro...

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PUM

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Abstract

The invention provides a Secnidazole vaginal effervescent tablet and its production method which comprises active constituent Secnidazole and effervescent tablet findings, wherein the Secnidazole amounts to 25-60% of the total weight.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, and in particular relates to a secnidazole vaginal effervescent tablet and a production method thereof. Background technique [0002] As early as the 1950s, it was discovered that 5-nitroimidazoles had antiprotozoal and antibacterial activities, and were successfully used in the clinical treatment of trichomonas, amoeba and other protozoa and various anaerobic Gram-positive and negative bacterial infections. Secnidazole belongs to 5-nitroimidazole derivatives, and its chemical name is: 1-(2-hydroxypropyl)-2-methyl-5-nitroimidazole hemihydrate. Clinically, secnidazole is mainly used to treat infections caused by a variety of anaerobic Gram-positive and negative bacteria and protozoa, especially Trichomonas vaginalis, Amoeba histolytica, Giardia lamblia and other diseases. It has a good curative effect on trichomoniasis vaginalis and bacterial vagino...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/46A61K31/4164A61P15/02A61P33/02
Inventor 都建强
Owner 苏州赫森医药科技有限公司
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