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Degradable blood vessel stent drug-eluting capable of reducing incidence rate of advanced thrombus

A drug coating, vascular stent technology, applied in the field of medical devices, can solve the problems of reduced bonding force between carriers and stents, carrier shedding, affecting cell and drug affinity, etc.

Inactive Publication Date: 2008-09-17
天津百畅医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] (3) More importantly, the surface of PLA material is highly hydrophobic, which affects its affinity with cells and drugs when it is used as a drug delivery material for tissue engineering scaffold materials
[0009] (4) The degradation method of this kind of degradable polymer, the bulk erosion spreads all over the carrier, the overall structure of the carrier will become loose, the water content will increase, the carrier will soon begin to disintegrate, the bonding force between the carrier and the bracket itself will decrease, and the carrier will be easily Shedding occurs, shortening the effective life of the drug film
When a biodegradable polymer material is used as a drug carrier, although the release rate of the drug from the carrier will also slow down with the degradation of the drug content, due to the gradual degradation of the drug carrier, the structure of the carrier becomes loose. The dissolution and diffusion of drug molecules from the carrier to the body are accelerated, and the drug release is increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment one: after the copolymer of 0.3g polytrimethylene carbonate and polylactic acid is dissolved in 10ml acetone, add 0.2g superoxide dismutase (SOD) and stir, dissolve evenly and After filtration, spray coating on the bottom layer of the parylene (Parylene) polymer film is covered with 0.1g cyclosporin A and 0.3g polytrimethylene carbonate and polylactic acid copolymer The surface of the 316L stainless steel stent coated with the intermediate drug is evaporated in nitrogen, and the angle of the stent is rotated to repeat spraying several times, so that it is evenly coated on the surface of the stent, and the solvent is evaporated in nitrogen, and then dried at room temperature under vacuum for 12 hours . Sterilized by ethylene oxide.

Embodiment 2

[0033] Example 2: After 0.2g of polyethylene glycol and polytrimethylene carbonate copolymer was dissolved in 10ml of acetonitrile, 0.5g of lycopene, 0.01g of coenzyme Q10 and 0.01g of coenzyme Q10 were added Vitamin E is stirred, dissolved evenly and filtered, sprayed on the bottom layer of the polymer film of Parylene, covered with 0.1g dactinomycin and 0.3g copolymer of polytrimethylene carbonate and polylactic acid intermediate drug-coated 316L stainless steel stent surface, volatilize the solvent in nitrogen, and rotate the angle of the stent to repeat spraying several times to make it evenly coated on the surface of the stent, evaporate the solvent in nitrogen and then spray in vacuum condition Dry at room temperature for 12 hours. Sterilized by ethylene oxide.

Embodiment 3

[0034] Example 3: After 0.3g of polytrimethylene carbonate and polylactic acid copolymer is dissolved in 10ml of ethanol, add 0.3g of coenzyme Q10 and 0.01g of rapamycin and stir to dissolve evenly After filtering and spraying onto the surface of a 316L stainless steel stent covered with a bottom layer of a parylene (Parylene) polymer film, and rotating the angle of the stent to repeat spraying several times to make it evenly coated on the surface of the stent, evaporate the solvent in nitrogen and then Dry at room temperature under vacuum for 12 hours. Sterilize with ethylene oxide.

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Abstract

The invention relates to a degradation blood vessel bracket drug coating layer, belonging to the technical field of medical instrument, which can depress late thrombosis incidence. The drug coating layer comprises the following materials: drug 1 to 50 percent and drug carrier 50 to 99 precent, which is characterized in that: the drug can be selected from a single antioxidation resisting drug, or mix of various antioxidation resisting drugs, or mix of a single or various anti-vascular restenosis drugs, or mix of a single or various antioxidation drugs and restenosis drugs. The drugs and medical bioceramics degradation polymer are uniformly coated on the surface of the blood vessel bracket adopting the mix or stratification method of application. The drug coating layer has the advantages of effectively relaxing and depressing late thrombosis incidence by local usage of medicine, and thus realizing the cure of coronary restenosis.

Description

Technical field: [0001] The invention relates to the field of medical devices, in particular to a degradable vascular stent drug coating that can reduce the incidence of late thrombus. Background technique: [0002] Atherosclerosis is an important disease that affects human health, and the disease that affects the coronary arteries of the heart is called coronary heart disease. Coronary heart disease often causes myocardial insufficiency, ranging from angina pectoris to myocardial infarction and even death. In 2000, ischemic heart disease accounted for 21.4% of all deaths in the United States, among which acute myocardial infarction accounted for 8%. Transcatheter interventional therapy is one of the most commonly used treatments for vascular obstructive diseases, especially percutaneous coronary angioplasty (PTCA) is a very effective treatment for coronary obstructive diseases. The polymer coating of the non-degradable stent currently used clinically is a foreign body to ...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L33/00
Inventor 刘泊志张志刚王闻宇
Owner 天津百畅医疗器械有限公司
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