43 results about "Delta-Tocopherol" patented technology

Disclosed are improvements in human nutrition involving a unique combination of natural products constituting anti-inflammatory compositions which can reduce cardiovascular disease risks as well as play a positive role in other conditions and diseases for which key indicators, especially selected from the group consisting of C-reactive protein (CRP) levels, cyclooxygenase-2 (COX-2), 5-lypoxygenase (5-LOX) expression and prostaglandin E2 (PGE-2) biosynthesis or any combination of these, are indicators. Therapeutic compositions preferably comprise curcumin, bilberry extract, grape seed extract, green tea extract and apple extract, in effective amounts individually and combined to provide a therapeutically significant reduction in one or more key indicators. Another exemplified therapeutic composition comprises: omega-3 rich refined fish oil, resveratrol, blueberry extract, grape seed extract, green tea extract and gamma and / or delta tocopherol, in effective amounts individually for the above benefits.

An edible oil in water emulsion comprising 40-99 wt. % of a continuous aqueous phase which phase contains 0.05-15 wt. % of a protein calculated on aqueous phase and, preferably, a thickener in an amount of 0.01-3 wt. %, 1-60 wt. % of a dispersed fat phase, the fat phase comprising 0.01-0.2 wt. % of alpha-tocopherol and a triglycerides mixture containing 10-80 wt. % of mono-unsaturated fatty acid residues, 10-80 wt. % of polyunsaturated fatty acid residues, 3-15 wt. % of omega-3 fatty acid residues, the balance up to 100 wt. % consisting of saturated fatty acid residues, fatty acid residues being calculated on fat phase, which emulsion is characterized in that it contains 0.005-0.05 wt. % of delta-tocopherol, while the weight ratio of delta-tocopherol and alpha-tocopherol in the emulsion is selected from the range 5 to 0.25.

The present invention relates to pharmaceutical compositions in form of solid lipidic nanospheres able to rapidly penetrate into the cells, comprising as an active substance a lipidic substance consisting of an ester of alpha-tocopherol or delta-tocopherol or of cholesterol or of glycerol with a carboxylic acid selected from acetic acid, propionic acid, butyric acid and succinic acid, useful in the treatment of tumoral pathologies and of Mediterranean anaemia.

The invention discloses a method for preparing high-purity natural vitamin E monomers by separating mixed tocopherol. The method comprises the following steps of: fully dissolving the mixed tocopherol in a mobile phase solvent I so as to obtain a loading solution; adding the loading solution into a reversed-phase chromatographic column; adding a mobile phase solvent II into the chromatographic column; and performing step-by-step collection to obtain effluent I of which the purity of d-alpha-tocopherol is more than or equal to 90 percent, effluent II of which the purity of d-gamma-tocopherol is more than or equal to 90 percent and effluent III of which the purity of d-delta-tocopherol is more than or equal to 85 percent. By the method, the one-time column loading and separation of raw materials can be realized under normal pressure so as to obtain three natural vitamin E monomers. A filler in the chromatographic column can be regenerated, the used solvents can be recovered, the cost is reduced, the method is convenient to operate, and the purity is high.

This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.

The invention discloses a method for separating D-alpha-tocopherol from mixed tocopherol, which comprises the following steps: an ionic liquid or a binary mixed solvent consisting of the ionic liquid and a polar solvent are taken as an extracting agent, and a fractional extraction method is adopted to efficiently separate the D-alpha-tocopherol from the mixed tocopherol containing the D-alpha-tocopherol, D-beta-tocopherol, D-gamma-tocopherol and D-delta-tocopherol. The method has the advantages of high separation efficiency, less solvent consumption, low production cost, safety, environmental protection, easy for industrialized production and so on.

An oral care composition, such as a dentifrice composition, which provides enhanced anti-gingivitis efficacy is disclosed. The composition includes a tocopherol component which consists of about 10% to about 90% of gamrnma tocopherol, with the balance of the components selected from alpha tocopherol, beta tocopherol, delta tocopherol, and mixtures thereof.

A dietary supplement for treating or preventing prostate disease and / or vascular disease including saw palmetto, d-alpha tocopherol, d-gamma tocopherol, d-delta tocopherol, d-beta tocopherol, selenium, lycopene, zinc, folic acid, vitamin B12, and vitamin B6, each in a therapeutically effective amount.

The invention discloses an assay kit for detecting 9 fat-soluble vitamins in blood serum by UPLC (Ultra Performance Liquid Chromatography). The 9 fat-soluble vitamins respectively are vitamin A, alpha-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-carotene, beta-carotene, a coenzyme Q10, lycopene and lutein. The kit comprises the following reagents: an eluent A, an eluent B, an eluent C, standard substance mother liquor, a diluent 1, a diluent 2, an extract liquor and control materials QC (L), QC (M) and QC (H). Compared with the prior art, the kit disclosed by the invention has the advantages that the kit disclosed by the invention is suitable for an analysis method for detecting the 9 fat-soluble vitamins in the blood serum by the UPLC; the method can save a sample, time and cost.

The invention discloses a medical application of gamma- and delta-tocopherol and derivatives thereof serving as novel radioprotectants. The invention relates to an application of a compound shown in a general formula I in the specification with the anti-radiation damage activity, an isomer of the compound and a medicine composition containing the compound and the isomer of the compound in the alleviation of hematopoietic function damage caused by radiation or / and chemotherapy drugs, the rising of blood leukocyte level and / or resistance of radiation damage, or tumor adjuvant therapy and the like or serving as tool drugs for researching radiation damage.

A dietary supplement for treating or preventing prostate disease and / or vascular disease including saw palmetto, d-alpha tocopherol, d-gamma tocopherol, d-delta tocopherol, d-beta tocopherol, selenium, lycopene, zinc, folic acid, vitamin B12, and vitamin B6, each in a therapeutically effective amount.

Anti-inflammatory compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and a prostaglandin E2 inhibitor, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chromanol is a gamma-tocopherol, delta-tocopherol, gamma-tocotrienol or delta-tocotrienol; said PGE2 inhibitor is a non-steroidal anti-inflammatory drug or an omega-3 fatty acid, such as docosahexaenoic acid and eicosapentaenoic acid.

An anti-oxidation composition comprises a component A natural vitamin E and tocopherol mixture and a component 2 alpha-tocopherol; and the natural vitamin E and tocopherol mixture is a natural vitamin E antioxidant containing alpha-tocopherol, beta-tocopherol, gamma-tocopherol and delta-tocopherol; and the natural vitamin E composite anti-oxidant has a good anti-oxidaiton effect, is a natural and green anti-oxidant, and is nontoxic and innocuous to human bodies. The alpha-tocopherol has high anti-oxidation ability at room temperature; and the gamma-tocopherol and the delta-tocopherol have long-duration anti-oxidation ability at a high temperature, and the gamma-tocopherol and the delta-tocopherol are compounded to generate synergism, so the anti-oxidation ability of food grade white oil is substantially improved.

The invention discloses an aminomethylation method for a tocopherol concentrated solution, which belongs to the field of fine organic synthesis. The tocopherol concentrated solution is a product prepared by distilling and purifying a plant oil deodorized distillate, and contains high-content mixed tocopherols (alpha, beta, gamma and delta-tocopherols). The beta, gamma and the delta-tocopherols are called non-alpha-tocopherol. A Mannic reaction is a condensation process of three components, i.e., a Mannich alkali serving as a product is prepared by condensing amine, aldehyde and non-alpha-tocopherol containing active hydrogen. In the invention, a high-yield Mannich alkali, i.e., non-alpha-tocopherol is generated by adopting a 'one-pot method', adding an amine reagent, an aldehyde reagent and the tocopherol concentrated solution into a reaction system and undergoing an aminomethylation reaction in the presence of an organic solvent. Due to the adoption of the method, the convention rate of the non-alpha-tocopherol can be over 99 percent in the absence of a catalyst, and the yield of the non-alpha-tocopherol generated in the reaction is over 98 percent.

The invention provides a preparation method of a feed-grade zinc oxide premixing agent. The preparation method comprises the following steps of (1) grinding zinc oxide powder, performing screening with an 80-mesh sieve to obtain fine powder, adding the fine powder into an ethanol water solution, dropwise adding a silane coupling agent solution, and taking suspension liquid for standby application; (2) adding a delta-tocopherol-ethanol solution to the suspension liquid under the normal atmospheric temperature, performing heating to 60-70 DEG C, performing a reaction for 2-3 hours, taking suspension liquid, performing filtering, washing filter cakes with ethanol, performing drying, performing grinding, and performing screening so as to obtain nanometer zinc oxide; (3) mixing the nanometer zinc oxide with starch, sodium hydroxypropycellulose, sodium cyclamate, a binder and a wetting agent through a mixing machine, performing granulation, performing shot blasting, and performing drying to obtain mini pills; and (4) performing screening on the mini pills with a classifying sieve so as to obtain the feed-grade zinc oxide premixing agent of which the particle size is 20-80 meshes. The zinc oxide particles in the made zinc oxide premixing agent are dispersed in a nanometer grade, so that the feed-grade zinc oxide premixing agent is uniform to disperse and not liable to agglomerate, has favorable biological value and utilization, and cannot generate side effects on growth of animals.

The invention discloses a cosmetic composition with a safe antioxidant effect. The cosmetic composition with the safe antioxidant effect is prepared from the raw material components in percentage by weight: 0.02-1.0% of small molecule hydrolyzed sodium hyaluronate, 0.02-1.0% of delta-tocopherol, 0.1-3.0% of a myrothamnus flabellifolia leaf / stem extract, 0.1-2.5% of a vitis vinifera fruit cell extract and 92.5-99.76% of a cosmetic auxiliary matrix. The cosmetic composition with the safe antioxidant effect is composed of the small molecule hydrolyzed sodium hyaluronate, the delta-tocopherol, thevitis vinifera fruit cell extract and the myrothamnus flabellifolia leaf / stem extract, the four substances supplement each other, especially the adding of the appropriate vitis vinifera fruit cell extract has obvious functions of reducing cytotoxicity and improving the antioxidant ability of the composition, and the safe antioxidant effect of skin care products can be achieved.

The invention provides a method for simultaneously detecting five fat-soluble vitamins, and an application thereof. The method comprises the following steps: (1) analyzing a pretreated sample by a liquid chromatograph-mass spectrometer; and (2) calculating the concentrations of the five fat-soluble vitamins in the sample to be tested according to a standard curve, wherein the fat-soluble vitaminscomprise retinol, alpha-tocopherol, beta-tocopherol, gamma-tocopherol and delta-tocopherol. A chromatographic column in the liquid chromatograph-mass spectrometer adopts gradient elution, and the mobile phase for the gradient elution is an ammonium formate-acetonitrile mixed solution. The recovery rate, the detection limit, the precision and other technical indicators of the method meet requirements, and isotope labels are used as internal standard substances, so the target compounds can be recognized in the manner of strong specificity, high sensitivity, good accuracy and short analysis time,and the method has a good reproducibility and a small error.

The invention discloses a synthesis method of an asymmetric disulfide compound shown in a formula (3). With an overcuring reagent RSSOMe shown in a formula (1) and nucleophilic reagents (2) and (4) asraw reaction materials, under the effect of a catalyst, through a reaction, the asymmetric disulfide compound is obtained. According to the method, the reaction conditions are mild, the raw materialsare low in price and easy to obtain, the reaction operation is simple, the yield is high, the metal catalysts are not needed in the reaction, an additional oxidizing agent or reducing agent does notneed to be added, and the method is environmentally friendly; a reaction substrate is easy to prepare; after reaction amplification, the reaction efficiency is high. The reaction in the method can beapplied to overcuring modification on benzazole and (+)-delta-tocopherol. The method has wide application prospects and high practical value.

The invention discloses a method for preparing high-purity natural vitamin E monomers by separating mixed tocopherol. The method comprises the following steps of: fully dissolving the mixed tocopherol in a mobile phase solvent I so as to obtain a loading solution; adding the loading solution into a reversed-phase chromatographic column; adding a mobile phase solvent II into the chromatographic column; and performing step-by-step collection to obtain effluent I of which the purity of d-alpha-tocopherol is more than or equal to 90 percent, effluent II of which the purity of d-gamma-tocopherol is more than or equal to 90 percent and effluent III of which the purity of d-delta-tocopherol is more than or equal to 85 percent. By the method, the one-time column loading and separation of raw materials can be realized under normal pressure so as to obtain three natural vitamin E monomers. A filler in the chromatographic column can be regenerated, the used solvents can be recovered, the cost is reduced, the method is convenient to operate, and the purity is high.

The invention relates to an extraction method of a tocopherol intermediate, belonging to the technical field of organic complexing extraction. The tocopherol intermediate is a product obtained after aminomethylation reaction of non-D-alpha-tocopherol in a tocopherol concentrated solution. The tocopherol concentrated solution contains higher-content mixed tocopherol (D-alpha, beta, gamma and delta-tocopherol), also contains a great amount of glyceride, fatty acid methyl ester, sterol ester and other impurities, and the preparation of high-content D-alpha-tocopherol is hindered by the existence of the impurities. The boiling points of the impurities are close to that of tocopherol, therefore, the impurities cannot be separated from tocopherol by distilling and other methods. The non-D-alpha-tocopherol intermediate is a tertiary amine substance, has certain alkalinity, and can be combined with an acid to form a salt, and glyceride and other impurities are easy to dissolve in an organic solvent. According to the invention, the tocopherol intermediate is extracted from glyceride and other impurities by a liquid-liquid extraction method, and the obtained non-D-alpha-tocopherol intermediate is almost pure, thus the purpose of purification is achieved.

The invention discloses a method for analyzing nutritional components in peony seed oil. The method comprises the following steps of preparing of materials, weighing, centrifuging, obtaining of seed oil extracting liquid, measuring of physical and chemical properties, analyzing of nutritional components, and statistic analyzing. The method has the advantages that the peony seeds in four development phases respectively 40d(S1), 60d(S2), 80d(S3) and 95d after flowering are respectively collected, so as to analyze the nutritional components of the seed oil; the analysis result is more comprehensive, and the used methanol, retinol, alpha-tocopherol, gamma-tocopherol and delta-tocopherol can respectively reach HPLC (high performance liquid chromatography) level; the sample separating ability isgreatly improved, the measuring of saponification value, measuring of iodine value and measuring of peroxide value are simultaneously performed with blank experiment for contrasting, the influence tothe results by the environment, used reagents and operation in the analysis process is avoided, the weight of the weighed peony seed oil is respectively accurate to the micrometer in the measuring ofphysical and chemical properties and analysis of nutritional components, and the measured value is more accurate.

An object of the present invention is to provide a composition for external use comprising a polyunsaturated fatty acid having higher stability over time. The present invention provides the following composition, in which the stability over time of a polyunsaturated fatty acid is high.A composition comprising a component (A) and a component (B) shown below, the component (B) being dispersed in a continuous phase that contains the component (A):(A) at least one member selected from the group consisting of tocopherol and phytic acid; and(B) liposomes containing a polyunsaturated fatty acid or a derivative thereof.

Use of delta-tocopherol for enhancing the heat stability and / or oxidation stability of a para-methoxycinnamic ester; an ultraviolet absorber comprising a para-methoxycinnamic ester, and an effective amount of delta-tocopherol to enhance its heat stability and / or oxidation stability; and a cosmetic comprising the above ultraviolet absorber. delta-tocopherol enhances the heat stability and / or oxidation stability of the para-methoxycinnamic ester which is an ultraviolet-absorbing substance frequently used.

The invention discloses a separation and purification method of d-delta-tocopherol. According to the method, a silica gel column chromatography process is combined with a resin ion exchange adsorption process, and ion exchange resin is subjected to CO2 desorption, so that the yield of d-delta-tocopherol is effectively increased. The method is relatively low in equipment requirement, low in energy consumption and suitable for industrialization.

The invention belongs to the technical field of biological fibers and functional materials and specifically relates to a low density lipoprotein adsorption microsphere and a preparation method and anadsorption material. The low density lipoprotein adsorption microsphere comprises a carrier; a hydrophobic functional group and heparinoid are coupled to the carrier; the mass ratio of the carrier, the heparinoid and the hydrophobic functional group is 1:(0.1-0.5):(0.1-0.5); the hydrophobic functional group consists of Delta-tocopherol and Alpha-tocopherol, wherein the content of the Delta-tocopherol does not exceed 5-8wt%. The low density lipoprotein adsorption microsphere provided by the invention has the advantages that the adsorption selectivity for LDL in whole blood is high, the adsorption rate of the LDL can reach up to 95% and above; more importantly, the damage to erythrocyte is low; the erythrocyte decrement rate is only 3.21%; and meanwhile, the filtering speed is high, the costis low, and the low density lipoprotein adsorption microsphere is suitable for large-scale promotion and application.

The invention discloses a method for analyzing the impact on RAW264.7 and K562 cells from IC50 dose delta-tocopherol on the basis of <1>H NMR metabonomics. The method comprises the following steps: (1) determining IC50 dose of delta-tocopherol to the RAW264.7 or K562 cells; (2) preparing a cell extract; (3) performing magnetic resonance imaging pretreatment; (4) performing <1>H magnetic resonance imaging detection; (5)screening differential metabolites; and (6)performing metabolism pathway analysis. According to the method, the H-nuclear magnetic resonance technology is combined with the metabonomics to study the impacts on differential metabolites and metabolic pathways of different cells, and the analytic method for studying the sub-toxicity of delta-tocopherol to the RAW264.7 and K562 cells is provided.

The invention concerns topical compositions based on retinaldehyde, glycylglycine oleamide and, if necessary, delta-tocopheryl-glucopyranoside, and their use in cosmetology and dermatology to combat skin ageing and more particularly light-induced skin ageing.

The invention provides a separation method of tocopherol homologous compounds. The method comprises the steps of: (1) mixing well one or more polar solvents with one or more non-polar solvents, and standing for phase separation to obtain an upper phase solvent and a lower phase solvent; (2) dissolving the tocopherol mixture in the upper phase solvent obtained in the step (1) as a sample to be separated; (3) using the upper phase solvent obtained in the step (1) as a stationary phase and the lower phase solvent obtained in the step (1) as a mobile phase, separating the sample to be separated in the step (2) by a high-speed countercurrent chromatography to obtain a mixed solution of tocopherol homologous compounds and the mobile phase, wherein the tocopherol homologous compounds comprise alpha-tocopherol, (beta + gamma)-tocopherol and delta-tocopherol; and (4) removing the mobile phase solvent in the mixed solution of tocopherol homologous compounds and the mobile phase obtained in the step (3), so as to obtain tocopherol homologous products.