Oral care compositions containing a mixed tocopherol component

A technology of oral care and tocopherol, which is applied in oral care, drug combination, pharmaceutical formula, etc., and can solve problems such as gingivitis has no effect

Inactive Publication Date: 2010-06-02
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alpha-tocopherol has been reported to penetrate gum tissue when applied topically in toothpaste but has no effect on gingivitis in primates and humans

Method used

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  • Oral care compositions containing a mixed tocopherol component
  • Oral care compositions containing a mixed tocopherol component
  • Oral care compositions containing a mixed tocopherol component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0036] The following four compositions of the invention were prepared using the preparation method described above. The mixed tocopherols shown in Table II comprise a 50:50 mixture of gamma tocopherol and alpha tocopherol.

[0037] Table II

[0038] raw material

[0039] raw material

[0040] The prepared dentifrice composition effectively cleans teeth and provides anti-gingivitis benefits to the user when used on a regular basis.

Embodiment II

[0042] Forty-one subjects of mixed gender, race and demographics were selected. All subjects were between 18 and 65 years old, in good general health, and diagnosed with gingivitis of varying severity.

[0043] The subjects were divided into two groups: group A and group B.

[0044] Group A was instructed to brush its teeth twice a day with toothpaste of formula A (see Table III) ("Toothpaste A").

[0045] Group B was instructed to brush its teeth twice a day with toothpaste of formula B (see Table III) ("Toothpaste B").

[0046] Table III

[0047] Material

Formula A

Formula B

sodium fluoride

0.24

0.24

saccharin

0.30

0.30

[0048] Material

Formula A

Formula B

Sorbitol

59.00

60.00

polyethylene glycol

3.00

3.00

carboxymethyl cellulose

0.60

0.60

tetrasodium pyrophosphate

0.50

0.50

Silica abrasive

25.50

25.50

fl...

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Abstract

An oral care composition, such as a dentifrice composition, which provides enhanced anti-gingivitis efficacy is disclosed. The composition includes a tocopherol component which consists of about 10% to about 90% of gamma tocopherol, with the balance of the components selected from alpha tocopherol, beta tocopherol, delta tocopherol, and mixtures thereof.

Description

Background of the invention [0001] Gum disease is a form of inflammation that occurs in the tissues of the mouth. Gingivitis (the early stage of gum disease) is inflammation of the gums caused by the buildup of plaque, the soft, sticky, colorless film of bacteria above the gum line. If not removed daily by proper brushing and flossing, plaque can build up on the teeth and gums, leading to gingivitis. Typical symptoms of gingivitis include red, swollen, tender gums that bleed when brushing. Left untreated, gingivitis can progress to more serious gum diseases, such as periodontitis, and eventually to bone destruction and tooth loss. [0002] Almost 80 percent of American adults have some form of gum disease. While gum disease can generally be treated to minimize gum disease with a fairly straightforward dental hygiene regimen (including regular brushing and flossing and professional dental cleanings), such hygiene routines are not always available. Strictly followed, this re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q11/00A61K8/67
CPCA61Q11/00A61K8/678A61P1/02A61P29/00A61P31/04
Inventor A·加法S·V·梅洛M·普伦西普
Owner COLGATE PALMOLIVE CO
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