A kind of separation and purification method of d-delta-tocopherol

Abstract

The invention discloses a separation and purification method of d-delta-tocopherol. According to the method, a silica gel column chromatography process is combined with a resin ion exchange adsorption process, and ion exchange resin is subjected to CO2 desorption, so that the yield of d-delta-tocopherol is effectively increased. The method is relatively low in equipment requirement, low in energy consumption and suitable for industrialization.

Description

technical field

[0001] The invention belongs to the field of chemical engineering, and in particular relates to a method for separating and purifying d-delta-tocopherol. Background technique

[0002] Natural vitamin E is a mixture mainly composed of four tocopherol homologues derived from tocols, including d-alpha-tocopherol, d-beta-tocopherol, d-gamma-tocopherol, and d- delta-tocopherol, both of which are saturated with C 16 The side chains differ only in the number and position of the methyl groups on the benzene ring. Although their structures are very similar, their biological activities are different, respectively d-α-tocopherol>d-β-tocopherol>d-γ-tocopherol>d-δ-tocopherol, and the antioxidant activity is d - the highest level of δ-tocopherol, d-β-, d-γ- and d-δ-tocopherol can be converted into d-α-tocopherol by chemical transformation method, so as to obtain high-purity concentrated d-α-tocopherol liquid. However, the separation and purification of d-δ-toc...