A kind of separation and purification method of d-delta-tocopherol

A purification method and technology of tocopherol, which is applied in the field of separation and purification of d-δ-tocopherol, can solve the problems of complex process, difficult industrial application, high separation cost, etc., and achieve the effect of increasing yield and requiring low equipment

A purification method and technology of tocopherol, which is applied in the field of separation and purification of d-δ-tocopherol, can solve the problems of complex process, difficult industrial application, high separation cost, etc., and achieve the effect of increasing yield and requiring low equipment

CN104230872BActive Publication Date: 2016-09-07NINGBO DAHONGYING BIO ENG
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Experimental program
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Embodiment 1

[0025] Weigh 20g of high-content mixed tocopherol concentrate (the high-content mixed tocopherol concentrate is obtained by preparation, preparation method: use DD oil as raw material, obtain mixed tocopherol concentrate by molecular distillation and ion exchange adsorption, the mixed tocopherol concentrate The content of tocopherol in the tocopherol concentrated solution is 30%), add 20ml n-hexane, be heated to fully dissolved, transfer the tocopherol solution to the top of the column that 200g of silica gel is housed, make it slowly flow through the silica gel column, until all the solutions are completely dissolved Completely adsorbed on the silica gel column, add 1BV (column volume) n-hexane to elute, then use 0.5BV of 3% tetrahydrofuran-n-hexane mixed eluent to elute the column, and then further increase the polarity of the mixed solvent, add 0.5BV 8% tetrahydrofuran-n-hexane mixed eluent to elute the column; in the above process, the eluent was collected in sections, and ...

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Abstract

The invention discloses a separation and purification method of d-delta-tocopherol. According to the method, a silica gel column chromatography process is combined with a resin ion exchange adsorption process, and ion exchange resin is subjected to CO2 desorption, so that the yield of d-delta-tocopherol is effectively increased. The method is relatively low in equipment requirement, low in energy consumption and suitable for industrialization.

Description

technical field [0001] The invention belongs to the field of chemical engineering, and in particular relates to a method for separating and purifying d-delta-tocopherol. Background technique [0002] Natural vitamin E is a mixture mainly composed of four tocopherol homologues derived from tocols, including d-alpha-tocopherol, d-beta-tocopherol, d-gamma-tocopherol, and d- delta-tocopherol, both of which are saturated with C 16 The side chains differ only in the number and position of the methyl groups on the benzene ring. Although their structures are very similar, their biological activities are different, respectively d-α-tocopherol>d-β-tocopherol>d-γ-tocopherol>d-δ-tocopherol, and the antioxidant activity is d - the highest level of δ-tocopherol, d-β-, d-γ- and d-δ-tocopherol can be converted into d-α-tocopherol by chemical transformation method, so as to obtain high-purity concentrated d-α-tocopherol liquid. However, the separation and purification of d-δ-toc...

Claims

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Application Information

Patent Timeline
07 Sep 2016
Publication
CN104230872B
IPC
C07D311/72
CPC
C07D311/72
Inventors
张源仁; 肖翔