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Mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy, and preparation method thereof

A technology for skin allergies and fermented liquid, applied in skin care preparations, medical preparations containing active ingredients, skin diseases, etc., can solve the problems of difficult removal of organic chemicals and low extraction efficiency, and achieve high dissolution rate and extraction Mild conditions and good stability

Inactive Publication Date: 2018-06-22
重庆雅素生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the mung bean extraction processes use physical and chemical extraction methods. During the extraction process, there are problems such as low extraction efficiency and difficult removal of organic chemical residues.

Method used

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  • Mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy, and preparation method thereof
  • Mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy, and preparation method thereof
  • Mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, anti-inflammatory effect test (24 hours suppress interleukin): as figure 1Shown is the biological equivalent test chart. The biological equivalent test shows that 2.0% mung bean lactic acid bacteria fermentation liquid can inhibit the inflammatory factor (interleukin-6) that causes excessive proliferation of keratinocytes by 85%; the inflammatory factor that causes redness (Interleukin-8), the inhibition is as high as 90%;

Embodiment 2

[0039] Embodiment two: Inhibition of hyaluronidase activity embodiment

[0040] Hyaluronidase is a participant in allergic reactions. Studies have shown that hyaluronidase has a strong correlation with inflammation and allergic reactions. The method of in vitro inhibition of hyaluronidase (Elson-Morgan) is used, as shown in the table below: Test results As shown in the display, with 2.0% dipotassium glycyrrhizinate as the positive control, sample I (solid content 5.0%), when taking its 2.0%, the inhibition rate is about higher than that of the positive control, which can reach 95%. Sample I (solid content 5.0%) .

[0041]

[0042] The data shows that through the test of inhibiting hyaluronidase activity, the anti-allergic effect of anti-allergic antibiotics is comparable to that of dipotassium glycyrrhizinate, or even more significant.

Embodiment 3

[0043] Embodiment three: RBC hemolysis embodiment

[0044] Fresh bovine blood was used to make red blood cells (RBC), so as to measure the hemolysis rate of the raw material itself and the hemolysis inhibition rate against SDS; the results of the examples are as follows:

[0045] 1) The results of the anti-allergicin autolysis control group: the 5.0% (mass percent) anti-allergicin aqueous solution in the system did not cause hemolysis of red blood cells, which proves that this raw material does not cause significant autolysis of red blood cells, indicating that this raw material No apparent irritant by itself.

[0046] 2) The inhibitory rate of antiallergicin on red blood cells damaged by SDS, adding 2.0% (mass percentage)) antiallergicin in the system The results of the examples show that the inhibition rate reaches 46.7%, which proves that the antiallergicin effectively reduces The damage of SDS to red blood cells can be judged as significantly reducing the potential irrita...

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Abstract

The invention discloses a mung bean fermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The mung bean fermentation broth comprises a wall-broken filtrate obtained after fermentation of mung bean sprouts via lactic acid bacteria, wherein the solid content of the filtrate is 1 to 20%. The invention also discloses a preparation method for the mung beanfermentation broth capable of repairing damaged skin surface lipid films and soothing skin allergy. The preparation method comprises the following steps: 1) germination of mung beans; 2) breeding of lactic acid bacteria; 3) liquid homogenization of mung bean sprouts, addition of milk and trace elements, steam sterilization and cooling; 4) inoculation of the lactic acid bacteria for fermentation; 5) high-pressure homogenization and wall breaking; 6) freeze concentration and coarse filtration; and 7) membrane filtration and degerming. According to the invention, mung bean seeds are subjected topreliminary germination at first and then to fermentation via lactic acid bacteria, and the obtained wall-broken filtrate is safe and free of any irritation during external application, and can substantially inhibit hyaluronidase, rapidly eliminate Bacillus acnes, reduce hyperpigmentation and inhibit the formation of acne scars.

Description

technical field [0001] The invention belongs to the technical field characterized by components, and in particular relates to a mung bean fermented liquid capable of repairing damaged sebum membranes and relieving skin allergies and a preparation method thereof. Background technique [0002] The reason why the skin can keep soft and smooth is mainly because the skin tissue contains a certain amount of water, and the oil secreted by the sebaceous glands in the skin and the sweat secreted by the sweat glands mix together to form a thin film on the surface of the skin. It is called "sebum film" in the world, it can not only moisturize the skin, but also greatly reduce the evaporation of water in the skin tissue; once the sebum film is damaged, not only the water retention function will be reduced, but also the skin will become dry, itchy and even peeling off The response to climate and other factors is also weakened, which can easily cause skin redness, local redness and even s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61K36/48A61P17/00A61P17/10A61P37/08
CPCA61K8/97A61K36/48A61K2236/19A61K2800/75A61K2800/782A61K2800/85A61Q19/004A61Q19/005A61Q19/007
Inventor 周朝强陈洋
Owner 重庆雅素生物科技有限公司
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