Mycoplasma hyopneumoniae and Mycoplasma hyorhinosus dual inactivated vaccine and preparation method thereof

Abstract

The invention provides a combined inactivated vaccine against mycoplasma hyopneumoniae (MHP) and mycoplasma hyorhinis. The combined inactivated vaccine contains the MHP and the mycoplasma hyorhinis with preferred content as well as a Carbomer adjuvant with concentration of 10% (V / V). The invention further provides a preparation method of the combined inactivated vaccine against the MHP and the mycoplasma hyorhinis. The preparation method comprises the following steps: preparing production strains; preparing bacterium solution for producing seedlings; and inactivating, concentrating and blending to obtain the vaccine. The combined inactivated vaccine has the advantages of strong specificity and good immunity, thus solving the problem of specific infection caused by the MHP in the current domestic breeding farm and obtaining the mycoplasma hyorhinis vaccine under a blank state at home and abroad at present. The combined inactivated vaccine has the beneficial effects that the step of vaccine inoculation is simplified, trouble caused by a plurality of inoculation and easily produced side effects are avoided, and vaccine cost is saved, thus being especially applicable to preventing andtreating mixed infection diseases in the breeding farms at home and abroad and the like; and compared with the existing single vaccine, application range is widened and immune effect is enhanced.

Description

technical field

[0001] The invention relates to a dual inactivated vaccine of Mycoplasma hyopneumoniae and Mycoplasma hyorhinosum and a preparation method thereof, belonging to the field of veterinary vaccines. Background technique

[0002] Swine panting disease, also known as swine mycoplasma pneumonia or porcine endemic pneumonia, is a contact chronic respiratory infectious disease caused by Mycoplasma hyopneumoniae, which is prevalent all over the world. The diseased pigs mainly showed cough and wheezing, growth retardation, low feed conversion rate, and normal body temperature. During anatomy, the main lesions were in the lungs, especially in the heart lobe, middle lobe, and apical lobe of the two lungs, which were characterized by pancreatoid changes and fleshy changes. High morbidity and low mortality. Studies in recent years have found that Mycoplasma hyopneumoniae is mixed with porcine reproductive and respiratory syndrome virus and other pathogens, which further i...

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