Mitoxantrone or mitoxantrone hydrochloride liposome injection and its preparing process

Abstract

Disclosed is a bangosome injection of mitoxantrone or and its preparing technique. The injection comprises of mitoxantrone, phospholipid, cholesterol, anti oxidant additive, organic acid, alkali, sugar, buffer and water for injection, the preparing technique includes preparation of lipid film, packaging medicine, homogenization of bangosome, purifying or solidifying bangosome, constant volume, degerming, subpackage and reposition and so on. The has remarkable stability, high ratio of packaging medicine, low cost, few poisonous side-effect and simple preparing technique.

Description

technical field

[0001] The invention relates to a preparation of mitoxantrone or mitoxantrone hydrochloride, in particular to a liposome injection of mitoxantrone or mitoxantrone hydrochloride, and also relates to a preparation process of the medicine. Background technique

[0002] Mitoxantrone or mitoxantrone hydrochloride is an anthracycline antitumor antibiotic, and its mechanism of action is mainly that mitoxantrone molecules enter the nucleus and bind to DNA, thereby inhibiting nucleic acid synthesis and mitosis, leading to cell death. Mitoxantrone or mitoxantrone hydrochloride is mainly used for malignant lymphoma, breast cancer and acute leukemia, for lung cancer, melanoma, soft tissue sarcoma, multiple myeloma, liver cancer, colorectal cancer, kidney cancer, prostate cancer, intrauterine Membranous cancer, testicular tumor, ovarian cancer and head and neck cancer are also effective.

[0003] Compared with doxorubicin hydrochloride, the long-term and short-term toxic...