A kind of active substance sustained-release material system for tissue repair and preparation method thereof

Abstract

The invention relates to the fields of biomedical materials, tissue engineering and medicine, and discloses an active substance slow-release material system for tissue repair. The active substance slow-release material system consists of three parts: an outer layer, a middle layer and an inner layer. The layer is a sodium alginate / bioactive glass / gluconolactone composite injectable hydrogel layer, the middle layer is a sodium alginate hydrogel microsphere layer wrapped with a repair factor, and the inner layer is a polylactic acid-hydroxyl layer wrapped with a drug. Acetic acid copolymer microsphere layer. The invention also discloses a preparation method of the active substance slow-release material system. The active substance sustained-release material system of the present invention can release the repair factors and drugs wrapped inside the material in an orderly manner according to the different stages of tissue regeneration in the wound repair process, and provide the corresponding active substances required for tissue regeneration in different stages, and can Better play the combined effect of repair factors.

Description

technical field [0001] The invention relates to the fields of biomedical materials, tissue engineering and medicine, in particular to the preparation of a multi-layer active substance slow-release material system and its application in tissue regeneration and repair. Background technique [0002] Tissue engineering is divided into in vitro tissue engineering and in vivo tissue engineering. In vitro tissue engineering requires a large number of seed cells and growth factors. However, there are many problems in the extraction and in vitro expansion of seed cells. It is difficult to obtain high-quality and sufficient seed cells, and the half-life of growth factors is short, expensive, and their behavior is difficult to control when used in vivo. In order to solve these problems, from the perspective of material design, a "tissue-inducing" biomaterial is prepared, which itself has bioactive materials, and the material is directly implanted in the body, and the bioactivity of the...

AI Technical Summary

Problems solved by technology

However, for the active substance delivery carrier material system that can meet the needs of different wound repair stages, the polymer polylactic acid-glycolic acid copolymer PLGA and PGA microsphere sustained-release system currently researched and applied, natural chitosan, sodium alginate, transparent Hyaluronic acid hydrogel sustained-release systems, liposome sustained-release systems, and composite sustained-release systems have the following defects: inactivation of loaded drugs; low coating rate of water-soluble drugs; excessively large stent pore size leads to serious loss of drugs or factors; Moreover, many studies only focus on a certain repair stage in the wound repair process, and each stage in the repair process has a great impact on its final repair effect

However, BG is usually in the form of powder or block, and its form is easy to be lost or not easy to be used, so the application range of BG is limited to a certain extent.

[0008] In the field of biomaterials and medicine, the problem of simulating multi-stage wound repair has not been effectively solved, and there is still a great demand for the combined application of multiple repair factors.

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