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Janus particle with chemotherapy/photo-thermal synergistic effect and preparation method thereof

A photothermal synergy and particle technology, applied in the field of biomedicine, can solve the problems that it is difficult to realize the combined treatment of cancer with multiple methods

Active Publication Date: 2018-10-26
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problem that other materials are not easy to achieve multiple methods of combined treatment of cancer, to provide a Janus particle with chemotherapy / photothermal synergistic effect and its preparation method

Method used

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  • Janus particle with chemotherapy/photo-thermal synergistic effect and preparation method thereof
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  • Janus particle with chemotherapy/photo-thermal synergistic effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The first step is to prepare aminated mesoporous silica nanoparticles: add 0.25 g cetyltrimethylammonium bromide (CTAB) to 120 mL water, raise the temperature to 80 °C, add 0.875 mL 2 mol / L hydroxide Sodium solution, add 1.25 mL of tetraethyl orthosilicate (TEOS) to the above solution, stir at 80°C for 2 h, centrifuge, remove the supernatant, and redisperse the bottom precipitate in 6.0% hydrochloric acid-methanol solution at 80°C Reflux for 8 hours to remove CTAB, and vacuum-dry the bottom precipitate after centrifugation to obtain dry mesoporous silica nanoparticles. Disperse 1.0 g of dry mesoporous silica nanoparticles in 50 mL of methanol, add 1.0 mL of 3-aminopropane Triethoxysilane (APTES) was refluxed at 80°C for 8 h, centrifuged, and the bottom precipitate was washed and dried in vacuum to obtain aminated mesoporous silica nanoparticles;

[0029] The second step is to prepare the Pickering emulsion of aminated mesoporous silica nanoparticles: disperse 20 mg of a...

Embodiment 2

[0033] The first step is to prepare aminated mesoporous silica nanoparticles: add 0.25 g cetyltrimethylammonium bromide (CTAB) to 120 mL water, raise the temperature to 80 °C, add 0.875 mL 2 mol / L hydroxide Sodium solution, add 1.25 mL of tetraethyl orthosilicate (TEOS) to the above solution, stir at 80°C for 2 h, centrifuge, remove the supernatant, and redisperse the bottom precipitate in 6.0% hydrochloric acid-methanol solution at 80°C Reflux for 8 hours to remove CTAB, and vacuum-dry the bottom precipitate after centrifugation to obtain dry mesoporous silica nanoparticles. Disperse 1.0 g of dry mesoporous silica nanoparticles in 50 mL of methanol, add 1.0 mL of 3-aminopropane Triethoxysilane (APTES) was refluxed at 80°C for 8 h, centrifuged, and the bottom precipitate was washed and dried in vacuum to obtain aminated mesoporous silica nanoparticles;

[0034] The second step is to prepare the Pickering emulsion of aminated mesoporous silica nanoparticles: disperse 50 mg of ami...

Embodiment 3

[0038] The first step is to prepare aminated mesoporous silica nanoparticles: add 0.25 g cetyltrimethylammonium bromide (CTAB) to 120 mL water, raise the temperature to 80 °C, add 0.875 mL 2 mol / L hydroxide Sodium solution, add 1.25 mL of tetraethyl orthosilicate (TEOS) to the above solution, stir at 80°C for 2 h, then centrifuge, remove the last supernatant, and redisperse the bottom precipitate in 6.0% hydrochloric acid-methanol solution for 80 Reflux at ℃ for 8 hours to remove CTAB, and vacuum-dry the bottom precipitate after centrifugation to obtain dry mesoporous silica nanoparticles. Disperse 1.0 g of dry mesoporous silica nanoparticles in 50 mL of methanol, add 1.0 mL of 3-ammonia Propyltriethoxysilane (APTES) was refluxed at 80°C for 8 h, centrifuged, the bottom precipitate was washed, and then vacuum-dried to obtain aminated mesoporous silica nanoparticles;

[0039] The second step is to prepare the Pickering emulsion of aminated mesoporous silica nanoparticles: 50 mg...

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Abstract

The invention provides a Janus particle with a chemotherapy / photo-thermal synergistic effect and a preparation method thereof and belongs to the technical field of biomedicines, aiming at solving thetechnical problem that combined treatment of various methods on cancers is not easy to realize by other materials. The particle is of a gold-silicon dioxide / mesoporous silicon dioxide Janus nano-structure; a gold nanoparticle is reduced on the surface of an aminated mesoporous silicon dioxide semi-sphere in situ through a Pickering emulsion method and different medicines are loaded at two ends respectively. The gold nanoparticle modified aminated mesoporous silicon dioxide Janus particle is prepared through the Pickering emulsion method. The Janus particle provided by the invention can be usedfor loading the two medicines at the same time and the ratio of the two medicines can be accurately controlled; the two medicines can respond medicine releasing through external signal stimulation including pH (Potential of Hydrogen), oxidization reduction and the like, and the technical problem that sudden releasing of the medicines is caused by an existing medicine nano-carrier is solved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a Janus particle with chemotherapy / photothermal synergistic effect and a preparation method thereof. Background technique [0002] Chemotherapy is the main treatment for most cancers, but the current traditional chemotherapy drugs still have the problems of poor specificity and severe side effects. In recent years, drug delivery systems based on nanomaterials have attracted much attention due to their good efficacy and low toxicity. However, in order to further improve the treatment efficiency in actual treatment, multi-drug synergistic treatment is usually required. However, it is difficult for isotropic particles to simultaneously load and release drugs with different physical and chemical properties, and it is not easy to synergize with multiple diagnosis and treatment methods. [0003] The surfaces of Janus particles have different morphology or chemical fun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/69A61K47/52A61K31/704A61K31/337A61P35/00
CPCA61K31/337A61K31/704A61K41/0052A61K47/52A61K47/6923A61P35/00A61K2300/00
Inventor 邢洋周影双少敏
Owner SHANXI UNIV
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