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X-ray pyrogenic composite nanoparticle

A nano-composite particle and X-ray technology, which is applied in the field of X-ray thermal nano-composite particles, can solve the problems of limited effective range and helplessness.

Inactive Publication Date: 2013-08-07
DALIAN MARITIME UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, no matter which nanomaterial is used or what kind of structural design is made, as far as the current PTA research is concerned, even if the infrared light excitation with the largest wavelength reported in the literature is used, its effective range of action in biological tissues is still limited to biological tissues. within the epidermis
Therefore, the current PTA technology is only suitable for the treatment of tumors in the surface tissue of the human body, but it is helpless for the tumors in the muscle tissue, internal organs, and bones of the organism.

Method used

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  • X-ray pyrogenic composite nanoparticle

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A kind of X-ray long afterglow luminescent particle spherical core is Yb 2 S 3 : Eu, Tm nanocomposite particles;

[0033] The preparation method of described nanocomposite particle comprises the following steps:

[0034] ① Preparation of spherical core of X-ray long afterglow luminescent particles;

[0035] 150mmol NaEt 2 CNS 2 ·3H 2 O was dissolved in 1000ml ethanol to obtain reagent I, 50mmol YbCl 3 , 1mmolEuCl 3 and 1 mmol TmCl 3 Dissolve in 250ml ethanol to obtain reagent II, mix reagent I and reagent II, stir for 30 minutes, filter to obtain a white precipitate, wash with ethanol and distilled water for 5 times, recrystallize with chloroform after washing, dry at 60°C for 12 hours after recrystallization, and obtain Yb -Eu(S 2 CNEt 2 ) 3 ;

[0036] 10mmol Yb-Eu (S 2 CNEt 2 ) 3 Dissolve in 320ml of acetonitrile to obtain reagent III, add reagent III to a 400ml polytetrafluoroethylene autoclave, keep the temperature at 200°C for 12 hours, cool to room ...

Embodiment 2

[0043] A kind of X-ray long afterglow luminescent particle spherical core is Yb 2 S 3 : Nanocomposite particles of Dy, Eu;

[0044] The preparation method of described nanocomposite particle comprises the following steps:

[0045] ① Preparation of spherical core of X-ray long afterglow luminescent particles;

[0046] 150mmol NaEt 2 CNS 2 ·3H 2 O was dissolved in 1000ml ethanol to obtain reagent I, 50mmol YbCl 3 , 1mmol EuCl 3 and 1 mmol DyCl 3 Dissolve in 250ml ethanol to obtain reagent II, mix reagent I and reagent II, stir for 30 minutes, filter to obtain a white precipitate, wash with ethanol and distilled water for 5 times, recrystallize with chloroform after washing, dry at 60°C for 12 hours after recrystallization, and obtain Yb -Dy-Eu(S 2 CNEt 2 ) 3 ;

[0047] 10mmol Yb-Dy-Eu (S 2 CNEt 2 ) 3 Dissolve in 320ml of acetonitrile to obtain reagent III, add reagent III to a 400ml polytetrafluoroethylene autoclave, keep the temperature at 200°C for 12 hours, coo...

Embodiment 3

[0054] A kind of X-ray luminescent particle spherical core is Yb 2 S 3 : Ce nanocomposite particles;

[0055] The preparation method of described nanocomposite particle comprises the following steps:

[0056] ① Preparation of spherical core of X-ray luminescent particles;

[0057] 150mmol NaEt 2 CNS 2 ·3H 2 O was dissolved in 1000ml ethanol to obtain reagent I, 50mmol YbCl 3 and 1 mmol CeCl 3 Dissolve in 250ml ethanol to obtain reagent II, mix reagent I and reagent II, stir for 30 minutes, filter to obtain a white precipitate, wash with ethanol and distilled water for 5 times, recrystallize with chloroform after washing, dry at 60°C for 12 hours after recrystallization, and obtain Yb -Ce(S 2 CNEt 2 ) 3 ;

[0058] 10mmol Yb-Ce (S 2 CNEt 2 ) 3 Dissolve in 320ml of acetonitrile to obtain reagent III, add reagent III to a 400ml polytetrafluoroethylene autoclave, keep the temperature at 200°C for 12 hours, cool to room temperature naturally, filter to obtain an orange...

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Abstract

The invention relates to an X-ray pyrogenic composite nanoparticle, which belongs to the technical field of medical inspection. The composite nanoparticle comprises an X-ray long-lasting phosphorescent particle core, a nanogold shell layer and an amino-modified silica shell layer, wherein the X-ray long-lasting phosphorescent particle core is wrapped in the nanogold shell layer, and the nanogold shell layer is wrapped in the amino-modified silica shell layer; and the X-ray long-lasting phosphorescent particle core is a rare-earth ion doped oxide, sulfide or oxysulfide nanoparticle, positive ions of oxide, sulfide or oxysulfide are metal ions and rare-earth ions, and doped ions are rare-earth ions. The X-ray pyrogenic composite nanoparticle disclosed by the invention has the beneficial effects that a micro dose of X-ray energy can be efficiently converted into heat energy which is enough to kill tumor cells, and after independent of X ray radiation, the production of heat energy has time continuity.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to an X-ray heating nanocomposite particle. Background technique [0002] According to a CCTV report on February 4, 2012, the number of cancer patients in the world increases by 11 million each year, and the number of cancer deaths exceeds 7 million each year, of which 24% occur in China. Malignant tumors have become the number one killer that seriously threatens the lives and health of people in our country and even in the world. In order to kill tumors, since 1896, radiotherapy, which uses high-energy radiation (such as X-rays, etc.) to destroy malignant cells, has been the most widely used and most effective treatment since it was first reported. Since tumor cells usually have the ability to repair radiation damage, in order to prevent tumor recurrence, radiotherapy usually requires a certain course of treatment to increase the total radiation dose. However, while hig...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K41/00A61P35/00
Inventor 付姚邢明铭罗昔贤张楠彭勇
Owner DALIAN MARITIME UNIVERSITY
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