Layered double-hydroxide nano drug-loaded compound and preparation and application thereof

A nanocomposite and hydroxide technology, which is applied in the field of layered double hydroxide nano drug-loaded compound and its preparation and application, can solve the complicated manufacturing process of the controlled-release drug-loaded platform, which cannot effectively control the release of drugs, It is unfavorable to problems such as large-scale production and application, and achieves the effects of high loading capacity, easy operation, and simple method

Active Publication Date: 2020-02-07
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a layered double hydroxide nano drug-loaded compound and its preparation and application, which overcomes the overheating of some photothermal materials under near-infrared laser irradiation in the current photothermal therapy of tumors. The defect of high damage to normal tissues and the complicated manufacturing process of the existing controlled release drug loading platform, the high cost is not conducive to large-scale production and application and the single method of drug controlled release, which cannot effectively control the release of drugs. In the present invention, HSP90 Inhibitor 17AAG loaded on Mn 2+ Doped MLDH nanosheets form a new nanoplatform for low-temperature photothermal PTT in cancer

Method used

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  • Layered double-hydroxide nano drug-loaded compound and preparation and application thereof
  • Layered double-hydroxide nano drug-loaded compound and preparation and application thereof
  • Layered double-hydroxide nano drug-loaded compound and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Mg(NO 3 ) 2 ·6H 2 O(0.0004mol), Al(NO 3 ) 3 9H 2 O(0.00019mol) and Mn(NO 3 ) 2 4H 2 O (0.00002mol) was dissolved in deionized water (40mL) to prepare solution A

[0056] (2) NaNO 3 (0.0002mol) was dissolved in 40 mL of deionized water containing 25% formamide to obtain solution B;

[0057] (3) NaOH (0.0045mol) was dissolved in deionized water (30mL) to obtain solution C.

[0058] (4) Slowly add solution A prepared in step 1 and solution C prepared in step 3 to solution B prepared in step 2, while stirring at 80°C for 30 minutes, centrifuge at 8000rpm to obtain MLDH nanosheets, and then further dialyze (3kDa) to remove formamide;

[0059] (5) Mix and dissolve the MLDH prepared in step 4 in water and add NH2-PEG-COOH, wherein the mass ratio of MLDH and NH2-PEG-COOH is 1:5, sonicate for 20min, magnetically stir for 12h, centrifuge at 8000rpm, freeze-dry MLDH-PEG was obtained.

[0060] The MLDH nanosheets prepared in this example are characterized by morpho...

Embodiment 2

[0063] (1) Mg(NO 3 ) 2 ·6H 2 O(0.0004mol), Al(NO 3 ) 3 9H 2 O(0.00019mol) and Mn(NO 3 ) 2 4H 2 O (0.00002mol) was dissolved in deionized water (40mL) to prepare solution A;

[0064] (2) NaNO 3 (0.0002mol) was dissolved in 40 mL of deionized water containing 25% formamide to obtain solution B;

[0065] (3) NaOH (0.0045mol) was dissolved in deionized water (30mL) to obtain solution C.

[0066] (4) Slowly add solution A prepared in step 1 and solution C prepared in step 3 to solution B prepared in step 2, while stirring at 80°C for 30 minutes, centrifuge at 8000rpm to obtain MLDH nanosheets, and then further dialyze (3kDa) to remove formamide;

[0067] (5) Dissolve 5 mg of MLDH obtained in step (4) in 20 mL of water and add 15 mg of NH2-PEG-COOH, sonicate for 20 min, magnetically stir for 12 h, centrifuge at 8000 rpm, and freeze-dry to obtain MLDH-PEG.

[0068] (6) Mix MLDH-PEG and 17AAG obtained in step (5) in 20 mL ultrapure water at a mass ratio of 1:1, stir magnet...

Embodiment 3

[0071] (1) Mg(NO3) 2 6H2O(0.0004mol), Al(NO3) 3 9H2O (0.00019mol) and Mn (NO 3 ) 2 4H 2 O (0.00002mol) was dissolved in deionized water (40mL) to prepare solution A

[0072] (2) NaNO 3 (0.0002mol) was dissolved in 40 mL of deionized water containing 25% formamide to obtain solution B;

[0073] (3) NaOH (0.0045mol) was dissolved in deionized water (30mL) to obtain solution C.

[0074] (4) Slowly add solution A prepared in step (1) and solution C prepared in step (3) to solution B prepared in step (2), while stirring at 80° C. for 30 minutes, and centrifuge at 8000 rpm to obtain MLDH nanosheets, Then further dialysis (3kDa) to remove formamide;

[0075](5) Dissolve 10 mg of MLDH obtained in step (4) in 20 mL of water and add 50 mg of NH2-PEG-COOH, sonicate for 20 min, magnetically stir for 12 h, centrifuge at 8000 rpm, and freeze-dry to obtain MLDH-PEG.

[0076] (6) Mix the MLDH-PEG of the present invention and 17AAG in ultrapure water according to the mass ratio of 2:1,...

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Abstract

The invention relates to a layered double hydroxide nano drug-loaded compound and preparation and application thereof, wherein the compound is obtained by sequentially modifying Mn2+(superscript) mixed layered double hydroxide (MLDH) nanosheets with NH2-PEG-COOH and loading a heat shock protein inhibitor 17AAG. The method is mild in reaction conditions and easy to operate, and has an industrialized implementation prospect.

Description

technical field [0001] The invention belongs to the field of drug-loaded composite material and its preparation and application, in particular to a layered double hydroxide nano drug-loaded composite and its preparation and application. Background technique [0002] Recently, the rapid development of new nanomaterials and nanotechnology has led to an upsurge in the study of effective treatment of tumors. Among various therapeutic strategies, photothermal therapy (PTT) has been widely explored in recent years due to its minimally invasive features and fewer side effects. Compared with conventional chemotherapy and radiotherapy, NIR-triggered PTT shows fewer side effects because those light absorbers are not toxic in the dark, and since light radiation parameters (e.g., duration, power density, location) can be precisely Control and therefore has great healing properties. Unfortunately, given the limited tissue penetration of light, it is impractical to provide sufficient he...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/60A61P35/00
CPCA61K41/0042A61K41/0052A61K47/60A61P35/00
Inventor 朱利民杨延波吴建荣
Owner DONGHUA UNIV
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