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MRI and PTT diagnosis and treatment integration functional microsphere with core-shell structure and preparation method thereof

A core-shell structure and function technology, applied in the field of material science and biomedicine, to achieve the effect of simple preparation method, uniform particle size and good stability

Inactive Publication Date: 2016-09-07
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although gadolinium-containing contrast agents have been clinically used for many years, their toxic side effects on the kidneys have attracted attention

Method used

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  • MRI and PTT diagnosis and treatment integration functional microsphere with core-shell structure and preparation method thereof
  • MRI and PTT diagnosis and treatment integration functional microsphere with core-shell structure and preparation method thereof
  • MRI and PTT diagnosis and treatment integration functional microsphere with core-shell structure and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] S1. Preparation of polypyrrole nanoparticles: Weigh 0.373g (0.00138mol) ferric chloride hexahydrate and dissolve it in 10mL of 7.5% PVA (polyvinyl alcohol) aqueous solution by weight, mix and stir for 1h in a 100ML flask, adjust The temperature of the water bath was kept at 5°C, and then 69ul (0.000995mol) of pyrrole monomer was added dropwise, reacted for 4h in a closed-light environment, centrifuged at 15000rmp, washed with hot water, and freeze-dried to obtain polypyrrole nanoparticles; the pyrrole monomer with Fe as an oxidizing agent 3+ The molar ratio is 0.72:1;

[0033] S2. Weigh 5mg of polypyrrole nanoparticles and disperse them in 10mL of deionized water, add 4mL of ethanol, 0.25mL of concentrated ammonia water (mass fraction is about 25%), after stirring, get in the alkaline mixed solution with pH about 9, weigh Dissolve 0.05 g of dopamine hydrochloride in 1 mL of deionized water to obtain an aqueous solution of dopamine hydrochloride (mass fraction is 4.76%)...

Embodiment 2

[0040] S1. Preparation of polypyrrole nanoparticles: Weigh 0.373g (0.00138mol) of ferric chloride hexahydrate and dissolve it in 10mL of a 7.5% PVA (polyvinyl alcohol) aqueous solution, mix and stir in a 100ML flask for 1h, adjust The temperature of the water bath was maintained at 5°C, then 62ul (0.000897mol) of pyrrole monomer was added dropwise, reacted for 4 hours in a closed-light environment, centrifuged at 15000 rmp, washed with hot water, and freeze-dried to obtain polypyrrole nanoparticles; wherein the pyrrole monomer was obtained. with Fe as oxidant 3+ The molar ratio is 0.65:1;

[0041] S2. Weigh 4 mg of polypyrrole nanoparticles and disperse them in 10 mL of deionized water, add 4 mL of methanol, 0.25 mL of concentrated ammonia water (about 25% by mass), and stir to obtain an alkaline mixed solution with a pH of about 9. 0.047 g of dopamine hydrochloride was dissolved in 1 mL of deionized water to obtain an aqueous solution of dopamine hydrochloride (4.5% by mass)...

Embodiment 3

[0044] S1. Preparation of polypyrrole nanoparticles: Weigh 0.373g (0.00138mol) of ferric chloride hexahydrate and dissolve it in 10mL of a 7.5% PVA (polyvinyl alcohol) aqueous solution, mix and stir in a 100ML flask for 1h, adjust The temperature of the water bath was maintained at 5°C, then 81ul (0.001173mol) of pyrrole monomer was added dropwise, reacted in a closed-light environment for 4 hours, centrifuged at 15,000 rmp, washed with hot water, and freeze-dried to obtain polypyrrole nanoparticles; wherein the pyrrole monomer was obtained. with Fe as oxidant 3+ The molar ratio is 0.85:1;

[0045] S2. Weigh 5 mg of polypyrrole nanoparticles and disperse them in 10 mL of deionized water, add 4 mL of propanol, 0.45 mL of concentrated ammonia (about 25% by mass), and stir to obtain an alkaline mixed solution with a pH of about 8. Dissolve 0.07 g of dopamine hydrochloride in 1 mL of deionized water to obtain an aqueous solution of dopamine hydrochloride (with a mass fraction of ...

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Abstract

The invention belongs to the fields of material science and biomedical application, and in particular relates to an MRI and PTT diagnosis and treatment integration functional microsphere with a core-shell structure and a preparation method thereof. The functional microsphere comprises a polypyrrole nano particle core and a polydopamine shell coated on the outer surface of the core, Fe3+ particles are arranged on the polydopamine shell in a complexing manner, the weight ratio of polypyrrole nano particles to polydopamine is 1: (3.1-10.2), and the weight ratio of the Fe3+ particles to the polydopamine is 1: (9.3-11.2). The preparation method comprises the following three steps: S1, preparation of the polypyrrole nano particles; S2, preparation of the nano microsphere with the core-shell structure; and S3, preparation of the MRI and PTT diagnosis and treatment integration functional microsphere. The functional microsphere is prepared by using the nontoxic polypyrrole and polydopamine with excellent biocompatibility, and is high in stability in blood of human bodies; moreover, the functional microsphere has T1 radiography effect and optothermal effect, can be used for magnetic resonance imaging (MRI) and photothermal therapy (PTT), and is a diagnosis and treatment integration functional material with great potential value.

Description

technical field [0001] The invention belongs to the field of material science and biomedicine, and specifically relates to a functional microsphere with a core-shell structure integrating MRI and PTT diagnosis and treatment and a preparation method thereof. Background technique [0002] Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique that provides precise real-time images of soft tissues. Intravenous injection of MRI contrast agent can highlight the difference between patient tissue and normal tissue, and help to locate the lesion more accurately. Although gadolinium-containing contrast agents have been used clinically for many years, their toxic side effects on the kidneys have attracted attention. In recent years, T1 contrast agents with good biocompatibility and low toxic and side effects have received more and more attention. Among them, complexes of polydopamine and ferric ions with T1 contrast function and excellent biocompatibility have be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12A61K41/00
CPCA61K49/1824A61K41/0052A61K49/126
Inventor 徐祖顺阳哲梁爽朱伟张力
Owner HUBEI UNIV
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