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Multifunctional bone filling material containing black phosphorus nanosheets and preparation method thereof

A filling material and nanosheet technology, applied in the fields of biomedicine and polymer materials, can solve the problems of lack of promotion of bone regeneration and poor osteoinductivity.

Inactive Publication Date: 2020-08-07
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although they are biocompatible and can meet clinical needs to a certain extent, they are poorly osteoinductive and lack the promotion of bone regeneration in complex disease conditions

Method used

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  • Multifunctional bone filling material containing black phosphorus nanosheets and preparation method thereof
  • Multifunctional bone filling material containing black phosphorus nanosheets and preparation method thereof
  • Multifunctional bone filling material containing black phosphorus nanosheets and preparation method thereof

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Effect test

Embodiment 1

[0047] A method for preparing a multifunctional bone filling material containing black phosphorus nanosheets, comprising the following steps:

[0048] 1. Preparation of black phosphorus nanosheet solution

[0049] (1) According to the ratio of black phosphorus chip to N-methylpyrrolidone 1mg: 1mL, weigh 50mg of black phosphorus (BP) crystals and dissolve them in 50mL of organic solvent N-methylpyrrolidone (NMP), and sonicate for 8h under ice bath conditions, Ultrasonic power: 400W, to obtain the mixed solution 1; centrifuge the mixed solution 1 at 3000rpm for 20min, discard the precipitate, and take the supernatant;

[0050] (2) After centrifuging the supernatant in step (1) at 10000 rpm for 20 min, take the precipitate, resuspend the precipitate with deionized water, centrifuge again at 10000 rpm for 20 min, and repeat the resuspension centrifugation 1-2 times;

[0051] (3) The precipitate obtained in step (2) was resuspended in deionized water to prepare a 1 mg / mL black pho...

Embodiment 2

[0061] 1. Preparation of black phosphorus nanosheet solution

[0062] (1) According to the ratio of black phosphorus chip to N-methylpyrrolidone 1mg: 1mL, weigh 50mg of black phosphorus (BP) crystals and dissolve them in 50mL of organic solvent N-methylpyrrolidone (NMP), and sonicate for 8h under ice bath conditions, Ultrasonic power: 400W, to obtain mixed solution 1; centrifuge mixed solution 1 at 3000rpm for 15min, discard the precipitate, and take the supernatant.

[0063] (2) After centrifuging the supernatant in step (1) at 8000rpm for 15min, take the precipitate, resuspend the precipitate with deionized water, centrifuge again at 8000rpm for 15min, and repeat the resuspension centrifugation 1-2 times.

[0064] (3) The precipitate obtained in step (2) was resuspended in deionized water to prepare a 1 mg / mL black phosphorus nanosheet (BPNs) solution.

[0065] 2. Preparation of hydrogel

[0066] (1) Add PVA (10g) to 100mL of deionized water to make the mass fraction 10wt%...

Embodiment 3

[0073] 1. Preparation of black phosphorus nanosheet solution

[0074] (1) According to the ratio of black phosphorus chip to N-methylpyrrolidone 1mg: 1mL, weigh 50mg of black phosphorus (BP) crystals and dissolve them in 50mL organic solvent N-methylpyrrolidone (NMP), and sonicate for 10h under ice bath conditions, Ultrasonic power: 400W, to obtain mixed solution 1; centrifuge mixed solution 1 at 4000rpm for 20min, discard the precipitate, and take the supernatant.

[0075] (2) After centrifuging the supernatant in step (1) at 12000 rpm for 20 min, take the precipitate, resuspend the precipitate with deionized water, centrifuge again at 12000 rpm for 20 min, and repeat the resuspension centrifugation 1-2 times.

[0076] (3) The precipitate obtained in step (2) was resuspended in deionized water to prepare a 1 mg / mL black phosphorus nanosheet (BPNs) solution.

[0077] 2. Preparation of hydrogel

[0078] (1) Add PVA (30g) to 100mL deionized water to make the mass fraction 30wt...

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Abstract

The invention discloses a multifunctional bone filling material containing black phosphorus nanosheets and a preparation method thereof. The multifunctional bone filling material is prepared from black phosphorus nanosheets, nano magnesium oxide, polyvinyl alcohol and chitosan. The specific preparation method comprises the following steps: preparing black phosphorus nanosheets; preparing a polyvinyl alcohol and chitosan hydrogel compound; loading the black phosphorus nanosheets and a nano magnesium oxide hydrogel compound, and the like. The multifunctional hydrogel bone filling stent disclosedby the invention overcomes the defects of poor complex disease resistance and poor osteogenesis induction of a stent system in the prior art, and the progress of bone defect repair under complex disease conditions is improved effectively.

Description

technical field [0001] The invention relates to the technical fields of biomedicine and polymer materials, and more specifically relates to a multifunctional bone filling material containing black phosphorus nanosheets and a preparation method thereof. Background technique [0002] There are more and more patients with bone defects caused by trauma, infection and tumors. Although human bone tissue has a certain self-healing ability, its self-healing ability is greatly reduced under the conditions of large bone defects, concurrent infections or tumors. How to improve the efficiency of bone defect repair is a focus of attention. Currently, common bone filling materials include: autologous bone, allogeneic bone and artificial bone. When the patient is in good health, traditional autologous bone and allogeneic bone implantation can improve the speed of bone repair, but when the patient has infection or tumor around the bone tissue, the traditional bone defect treatment The eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/46A61L27/56C04B26/28
CPCA61L27/446A61L27/46A61L27/56A61L2300/102A61L2300/112A61L2300/404A61L2400/12A61L2430/02C04B26/28C04B2111/00836C04B2111/2092C04B24/2623C04B22/066C04B22/02C08L5/08C08L29/04
Inventor 秦彦国卿云安李瑞延房旭高鑫
Owner JILIN UNIV
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