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Porous biological ceramic calcium silicate stent with photo-thermal function and preparation method thereof

A technology of porous calcium silicate and bioceramics

Inactive Publication Date: 2019-04-19
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, loading photothermal reagents on calcium silicate bioceramics also has problems such as complicated preparation process.

Method used

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  • Porous biological ceramic calcium silicate stent with photo-thermal function and preparation method thereof
  • Porous biological ceramic calcium silicate stent with photo-thermal function and preparation method thereof
  • Porous biological ceramic calcium silicate stent with photo-thermal function and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0035] A preparation method of a photothermal functional porous calcium silicate bioceramic support based on a silicone resin precursor comprises the following steps:

[0036] Step 1, prepare silicone resin-alcohol solution. Mix the silicone resin and isopropanol at a mass volume ratio of 1.25 g / ml, stir until completely dissolved to obtain a silicone resin-alcohol solution, and then seal and store.

[0037] Step 2, preparing active additive / silicone resin printing paste. Pass the calcium carbonate powder through a 400-mesh sieve, then take the calcium carbonate, add the silicone resin-alcohol solution obtained in step 1 according to the mass ratio of calcium carbonate and silicone resin of 5:1, stir evenly to obtain the printing paste, and then seal it for storage .

[0038] Step three, designing the external shape and internal structure of the active additive / silicone resin scaffold. Using CAD computer-aided software to design the external shape and internal structure of ...

Embodiment 2

[0063] A preparation method of a photothermal functional porous calcium silicate bioceramic support based on a silicone resin precursor comprises the following steps:

[0064] Step 1, prepare silicone resin-alcohol solution. Mix the silicone resin and methanol at a mass volume ratio of 3 g / ml, stir until completely dissolved to obtain a silicone resin-alcohol solution, and then seal and store.

[0065] Step 2, preparing active additive / silicone resin printing paste. Pass the calcium oxide powder through a 300-mesh sieve, then take a certain amount of calcium oxide, add the silicone resin-alcohol solution obtained in step 1 according to the mass ratio of calcium oxide and silicone resin at 3:1, and stir evenly to obtain the printing paste. Then keep it sealed.

[0066] Step three, designing the external shape and internal structure of the active additive / silicone resin scaffold. CAD computer-aided software was used to design the external shape and internal structure of the s...

Embodiment 3

[0070] A preparation method of a photothermal functional porous calcium silicate bioceramic support based on a silicone resin precursor comprises the following steps:

[0071] Step 1, prepare silicone resin-alcohol solution. Mix the silicone resin and isobutanol at a mass volume ratio of 1 g / ml, stir until completely dissolved to obtain a silicone resin-alcohol solution, and then seal and store.

[0072] Step 2, preparing active additive / silicone resin printing paste. Pass the calcium sulfate powder through a 200-mesh sieve, then take calcium sulfate, add the silicone resin-alcohol solution obtained in step 1 according to the mass ratio of calcium sulfate and silicone resin at 4:1, stir evenly to obtain printing paste, and then seal and store .

[0073] Step three, designing the external shape and internal structure of the silicone resin / active additive scaffold. Using CAD computer-aided software to design the external shape and internal structure of the scaffold, the scaff...

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Abstract

The invention relates to a porous biological ceramic calcium silicate stent with a photo-thermal function and a preparation method thereof. The preparation method of the stent comprises the followingsteps of 1, preparing a silicon resin-alcohol solution; 2, preparing an active additive / silicon resin printing slurry; 3, preparing a porous stent blank; 4, preparing the porous biological ceramic calcium silicate stent. Compared with the prior art, a polymer precursor method based on a silicon resin precursor has the advantages that in combination with a three-dimensional printing technology, theporous biological ceramic calcium silicate stent which contains carbon dots and achieves the photo-thermal treatment function is prepared, the internal structure of the stent is easy to control, andthe growth of new bones can be promoted; under illumination of infrared light, tumor cells can be killed, the growth of tumors is inhibited, and it is expected that a new strategy is provided for repairing treatment of bone damage after a clinical bone tumor operation.

Description

technical field [0001] The invention belongs to the technical field of bone tissue engineering scaffolds, and relates to a porous calcium silicate bioceramic scaffold with photothermal function and its preparation. Background technique [0002] At present, the treatment of primary bone tumors and metastatic malignant bone tumors is still a very big clinical challenge. Curettage surgery is the most important method for the clinical treatment of bone tumors, but the residual tumor cavity and the potential threat of local tumor recurrence and metastasis will seriously affect the quality of life of patients. Therefore, repairing bone defects, performing tissue reconstruction and Killing residual tumor cells is still a problem that must be solved in the clinical treatment of bone tumors. [0003] Among them, in bone tissue repair materials, calcium silicate bioceramics (such as CaSiO 3 , Ca 2 SiO 4 or Ca 3 SiO 5 ) has a good bone repair function, and its good biological act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/22C04B35/622C04B38/00B33Y70/00B33Y10/00
CPCB33Y10/00B33Y70/00C04B35/22C04B35/622C04B38/0051C04B38/0054C04B2235/3208C04B2235/442C04B2235/448C04B2235/483
Inventor 朱钰方傅声扬
Owner UNIV OF SHANGHAI FOR SCI & TECH
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