Photoluminescence-photothermal nano composite structural material and preparation method and application thereof

A nanocomposite and structural material technology, applied in luminescent/biological dyeing preparations, wave energy or particle radiation treatment materials, pharmaceutical formulations, etc., can solve the problems of difficult biological optical temperature detection, high price, toxicity, etc., and achieve major applications Foreground, High Accuracy, Low Side Effects

Active Publication Date: 2016-06-15
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows for better control over how much energy (light) gets into cells during thermal treatments like photoablative procedures or ablation techniques that target specific areas inside them. It also helps monitor cellular responses after these treatments by measuring their temperatures at different wavelength ranges. By incorporating this technology within certain types of medical devices made from plastic, they are able to improve patient outcomes while reducing harmful radiation exposure.

Problems solved by technology

This patents describes different types of optoacoustic techniques called photoimmunotherapy, where laser radiation generates heat inside tumor areas while minimizing harm caused by overexposure during excitation. These technologies involve delivering specialized photosensitizers into target regions within patients' bodies before exposuring them to electromagnetic waves from sunlight. By measuring changes in certain parameters like absorbance coefficients, temperatures can be accurately detected without causing any issues related to health. Additionally, current methods involving complex mixtures may result in unintended results when incorporating multiple components. Overall, the proposed solution involves developing novel compositions containing various materials optimized for precise temperature measurement and combined together to create effective treatments for photonocaltropy necrosis disease.

Method used

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  • Photoluminescence-photothermal nano composite structural material and preparation method and application thereof
  • Photoluminescence-photothermal nano composite structural material and preparation method and application thereof
  • Photoluminescence-photothermal nano composite structural material and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Example 1: NaLu 0.78 Yb 0.2 Er 0.02 f 4 NaLuF 4 Synthesis of Carbon

[0050] Weigh Lu(CF 3 COO) 3 0.78mmol, Yb(CF 3 COO) 3 0.2mmol, Er(CF 3 COO) 3 0.02mmol, Na(CF 3 COO) 3mmol, add solvent oleylamine 3mL, oleic acid 3mL, 1-octadecene 15mL, heat and stir at 90°C for 30 minutes to dissolve to form a homogeneous solution, and then open to evaporate water for 30 minutes. Under the protection of nitrogen atmosphere, the temperature was raised to 330° C., kept for 60 minutes, and then cooled to room temperature. The same volume of ethanol was added to the cooled solution, the solid was obtained by centrifugation, and the obtained solid was washed three times with a solution of ethanol:cyclohexane (1:1 v / v). Then weigh Lu(CF 3 COO) 3 1mmol, Na(CF 3 COO) 3 mmol, 6 mL of solvent oleic acid and 15 mL of 1-octadecene were added thereto, heated and stirred at 90° C. for 30 minutes to dissolve to form a homogeneous solution, and then the water was evaporated open for ...

Embodiment 2

[0051] Example 2: LiY 0.35 Yb 0.05 Nd 0.6 f 4 YF 4 Synthesis of Polypyrrole

[0052] Weigh Y(CF 3 COO) 3 0.35mmol, Yb(CF 3 COO) 3 0.05mmol, Nd(CF 3 COO) 3 0.6mmol, Li(CF 3 COO) 2mmol, add solvent oleylamine 3mL, oleic acid 3mL, 1-octadecene 15mL, heat and stir at 90°C for 30 minutes to dissolve to form a homogeneous solution, and then open to evaporate water for 30 minutes. Under the protection of nitrogen atmosphere, the temperature was raised to 310° C., kept for 60 minutes, and then cooled to room temperature. The same volume of ethanol was added to the cooled solution, the solid was obtained by centrifugation, and the obtained solid was washed three times with a solution of ethanol:cyclohexane (1:1 v / v). Then weigh Y(CF 3 COO) 3 1mmol, Li(CF 3 COO) 2mmol, add 6mL of solvent oleic acid, 15mL of 1-octadecene, heat and stir at 80~100°C for 30 minutes to dissolve to form a homogeneous solution, and then evaporate the water for 30 minutes. Add the solid obtained...

Embodiment 3

[0053] Example 3: LiLu 0.95 Nd 0.05 f 4 LiF 4 Synthesis of PEDOT

[0054] Weigh Lu(CF 3 COO) 3 0.95mmol, Nd(CF 3 COO) 3 0.05mmol, Li(CF 3 COO) 3mmol, add 3mL of solvent oleylamine, 3mL of oleic acid, 15mL of 1-octadecene, heat and stir at 90°C for 30 minutes to dissolve to form a uniform solution, and then evaporate the water for 30 minutes. Under the protection of nitrogen atmosphere, the temperature was raised to 330° C., kept for 60 minutes, and then cooled to room temperature. The same volume of ethanol was added to the cooled solution, the solid was obtained by centrifugation, and the obtained solid was washed three times with a solution of ethanol:cyclohexane (1:1 v / v). Then weigh Lu(CF 3 COO) 3 1mmol, Li(CF 3 COO) 3 mmol, 6 mL of solvent oleic acid and 15 mL of 1-octadecene were added thereto, heated and stirred at 90° C. for 30 minutes to dissolve to form a homogeneous solution, and then the water was evaporated open for 30 minutes. Add the solid obtained ...

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Abstract

The invention belongs to the technical field of optical nano probe, and in particular, relates to a photoluminescence-photothermal nano composite structural material and a preparation method and an application thereof. The composite structural material takes a rare earth fluoride as a core and is a core-shell structural nano material with the exterior wrapped with an organic photothermal substance layer; the material generates 800-1200 nm near infrared fluorescence emission under excitation by a 700-1000 nm near infrared laser, the photo-thermal substance layer can convert optical energy into heat energy to achieve photothermal therapy of tumor. During use, the probe temperature is monitored while the probe performs photothermal therapy; furthermore, the probe is co-incubated with tumor cells or is injected into tumor mice through veins, and high-resolution cancer photothermal therapy and simultaneous optical temperature monitoring can be achieved. The invention provides an effective temperature monitoring tool for photothermal therapy, the damage to normal tissues in tumor thermotherapy can be reduced, and significant application prospects in the field of biomedicine are achieved.

Description

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Claims

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Application Information

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Owner FUDAN UNIV
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