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Up-conversion luminescence-thermo-chemotherapy composite nano probe as well as preparation method and application thereof in combined treatment programmed control

A technology of nanoprobes and thermochemotherapy, applied in the field of nanoprobes, can solve problems such as inability to carry out separately

Active Publication Date: 2018-05-29
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, chemotherapy and hyperthermia will be triggered at the same time, and cannot be performed separately

Method used

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  • Up-conversion luminescence-thermo-chemotherapy composite nano probe as well as preparation method and application thereof in combined treatment programmed control
  • Up-conversion luminescence-thermo-chemotherapy composite nano probe as well as preparation method and application thereof in combined treatment programmed control
  • Up-conversion luminescence-thermo-chemotherapy composite nano probe as well as preparation method and application thereof in combined treatment programmed control

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Example 1: NaLu 0.78 Yb 0.2 Er 0.02 f 4 @NaLuF 4 @SiO 2 -Synthesis of PdPc@DPPC-DOX

[0073] Weigh Lu(CF 3 COO) 3 0.78mmol, Yb(CF 3 COO) 3 0.2mmol, Er(CF 3 COO) 3 0.02mmol, Na(CF 3 COO) 3mmol, add solvent oleylamine 3mL, oleic acid 3mL, 1-octadecene 15mL, heat and stir at 90°C for 30 minutes to dissolve to form a homogeneous solution, and then open to evaporate water for 30 minutes. Under the protection of nitrogen atmosphere, the temperature was raised to 330° C., kept for 60 minutes, and then cooled to room temperature. The same volume of ethanol was added to the cooled solution, the solid was obtained by centrifugation, and the obtained solid was washed three times with a solution of ethanol:cyclohexane (1:1 v / v).

[0074] Then weigh Lu(CF 3 COO) 3 1mmol, Na(CF 3COO) 3 mmol, 6 mL of solvent oleic acid and 15 mL of 1-octadecene were added thereto, heated and stirred at 90° C. for 30 minutes to dissolve to form a homogeneous solution, and then the w...

Embodiment 2

[0080] Example 2: NaY 0.78 Yb 0.2 Er 0.02 f 4 @NaYF 4 @SiO 2 -Synthesis of ICG@PNIPAm-PTX

[0081] Weigh Y(CF 3 COO) 3 0.78mmol, Yb(CF 3 COO) 3 0.2mmol, Er(CF 3 COO) 3 0.02mmol, Na(CF 3 COO) 3mmol, add solvent oleylamine 3mL, oleic acid 3mL, 1-octadecene 15mL, heat and stir at 90°C for 30 minutes to dissolve to form a homogeneous solution, and then open to evaporate water for 30 minutes. Under the protection of nitrogen atmosphere, the temperature was raised to 330° C., kept for 60 minutes, and then cooled to room temperature. The same volume of ethanol was added to the cooled solution, the solid was obtained by centrifugation, and the obtained solid was washed three times with a solution of ethanol:cyclohexane (1:1 v / v).

[0082] Then weigh Y(CF 3 COO) 3 1mmol, Na(CF 3 COO) 3 mmol, 6 mL of solvent oleic acid and 15 mL of 1-octadecene were added thereto, heated and stirred at 90° C. for 30 minutes to dissolve to form a homogeneous solution, and then the wat...

Embodiment 3

[0086] Example 3: NaLu 0.78 Yb 0.2 Er 0.02 f 4 @NaLuF 4 @SiO 2 -Synthesis of CuPc@DPPC-GEM

[0087] Weigh Lu(CF 3 COO) 3 0.78mmol, Yb(CF 3 COO) 3 0.2mmol, Er(CF 3 COO) 3 0.02mmol, Na(CF 3 COO) 3mmol, add solvent oleylamine 3mL, oleic acid 3mL, 1-octadecene 15mL, heat and stir at 90°C for 30 minutes to dissolve to form a homogeneous solution, and then open to evaporate water for 30 minutes. Under the protection of nitrogen atmosphere, the temperature was raised to 330° C., kept for 60 minutes, and then cooled to room temperature. The same volume of ethanol was added to the cooled solution, the solid was obtained by centrifugation, and the obtained solid was washed three times with a solution of ethanol:cyclohexane (1:1 v / v).

[0088] Then weigh Lu(CF 3 COO) 3 1mmol, Na(CF 3 COO) 3 mmol, 6 mL of solvent oleic acid and 15 mL of 1-octadecene were added thereto, heated and stirred at 90° C. for 30 minutes to dissolve to form a homogeneous solution, and then the ...

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Abstract

The invention belongs to the technical field of nano probes, and particularly provides an up-conversion luminescence-thermo-chemotherapy composite nano probe as well as a preparation method and application thereof in combined treatment programmed control. The up-conversion luminescence-thermo-chemotherapy composite nano probe adopts two layers of rare-earth fluoride as a core, an intermediate layer is a hollow silicon dioxide shell layer loaded with a photo-thermal material, an outer layer is an organic molecular membrane loaded with a micromolecular chemotherapy drug, and a structural generalformula is NaL1-x-yYbxEryF4@NaLF4@SiO2-M@N-P. When the nano composite material provided by the invention is illuminated by near-infrared rays, photo-thermal molecules generate the heat energy to promote the dissociation of a thermosensitive coating, so that the chemotherapy drug molecules are released, the cancer chemotherapy is realized, the heat energy generated by the photo-thermal molecules can also thermally kill the cancer cells, the drug release and the photo-thermal treatment in the combined cancer treatment can be performed in a programming step-by-step manner, and the dosage of thechemotherapy drug and the heat energy can be reduced by utilizing the strategy.

Description

technical field [0001] The invention belongs to the technical field of nanoprobes, and specifically relates to a preparation method of an upconversion luminescence-thermal chemotherapy composite nanoprobe and the control of the operation sequence of different treatment modes in combined cancer treatment, so as to optimize the effect of cancer treatment and reduce the administration of drugs Increase the amount. Background technique [0002] Combination therapy for cancer is a treatment strategy that combines two or more treatment modalities. Since the anti-cancer mechanisms of different treatment modes are different, combination therapy can often show cumulative killing effects, thereby reducing the probability of cancer progression and recurrence. Recently, the concept of combined therapy has been adopted by researchers to design some nanomaterial-based probes for cancer therapy. The current development of nanoprobes with combined therapeutic functions has involved the co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/04A61K47/24A61K47/32A61K31/704A61P35/00
CPCA61K9/5115A61K9/5123A61K9/5138A61K31/704A61K41/0028A61K41/0052A61K2300/00
Inventor 李富友冯玮朱幸俊
Owner FUDAN UNIV
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