A photoluminescence-photothermal nanocomposite structure material and its preparation method and application

Abstract

The invention belongs to the technical field of optical nano probe, and in particular, relates to a photoluminescence-photothermal nano composite structural material and a preparation method and an application thereof. The composite structural material takes a rare earth fluoride as a core and is a core-shell structural nano material with the exterior wrapped with an organic photothermal substance layer; the material generates 800-1200 nm near infrared fluorescence emission under excitation by a 700-1000 nm near infrared laser, the photo-thermal substance layer can convert optical energy into heat energy to achieve photothermal therapy of tumor. During use, the probe temperature is monitored while the probe performs photothermal therapy; furthermore, the probe is co-incubated with tumor cells or is injected into tumor mice through veins, and high-resolution cancer photothermal therapy and simultaneous optical temperature monitoring can be achieved. The invention provides an effective temperature monitoring tool for photothermal therapy, the damage to normal tissues in tumor thermotherapy can be reduced, and significant application prospects in the field of biomedicine are achieved.

Description

technical field [0001] The invention belongs to the technical field of optical nano-probes, and in particular relates to a novel composite structure nano-optical probe material, a preparation method thereof, and an application in photothermal treatment of tumors and real-time microscopic temperature monitoring. Background technique [0002] As an emerging cancer treatment, photothermal therapy has been extensively studied in recent years. Photothermal therapy is a process in which nano-optical absorbing materials are used to generate heat energy to kill cancer cells under the irradiation of light sources of specific wavelengths (usually near-infrared light). Compared with traditional hyperthermia methods (such as microwave hyperthermia, radiofrequency ablation, etc.), photothermal therapy is less invasive and easier to operate. In theory, it can achieve higher treatment accuracy and lower side effects. A promising approach to cancer therapy. [0003] Due to the lack of goo...

AI Technical Summary

Problems solved by technology

Current optical temperature probes such as quantum dots, nanodiamonds, and small organic molecules all emit at a single wavelength, which is prone to large detection errors due to absorption, scattering, and sample movement in organisms, so it is difficult to achieve better Optical temperature detection of living organisms

Rare-earth element-doped up-conversion luminescent materials have become research hotspots because of their unique luminescence characteristics, which are very suitable for biological imaging. However, the emission bands used by ytterbium- and erbium-doped rare-earth up-conversion luminescent temperature detection materials are in the visible light green Photozone, which has a low penetration depth in living organisms and is not conducive to temperature monitoring of in vivo photothermal therapy

In addition, the combination of optical nanometer temperature probes and photothermal materials is still relatively cumbersome, which is not conducive to large-scale preparation and promotion, and most of the photothermal materials used are gold, silver, palladium, copper and other metals, which are expensive and have potential toxicity

Although it has been reported that rare earth elements are used as photothermal materials, they are not ideal photothermal materials due to their relatively low light absorption coefficient and low heat conversion efficiency.

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