A photoluminescence-photothermal nanocomposite structure material and its preparation method and application

A nano-composite, structural material technology, applied in luminescent/biological dyeing preparations, wave energy or particle radiation treatment materials, pharmaceutical formulations, etc., can solve the problems of difficult biological optical temperature detection, toxicity, high price, etc., and achieve major applications Prospect, low side effects, high precision effects
CN105664158BActive Publication Date: 2019-11-12FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2019-11-12

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Abstract

The invention belongs to the technical field of optical nano probe, and in particular, relates to a photoluminescence-photothermal nano composite structural material and a preparation method and an application thereof. The composite structural material takes a rare earth fluoride as a core and is a core-shell structural nano material with the exterior wrapped with an organic photothermal substance layer; the material generates 800-1200 nm near infrared fluorescence emission under excitation by a 700-1000 nm near infrared laser, the photo-thermal substance layer can convert optical energy into heat energy to achieve photothermal therapy of tumor. During use, the probe temperature is monitored while the probe performs photothermal therapy; furthermore, the probe is co-incubated with tumor cells or is injected into tumor mice through veins, and high-resolution cancer photothermal therapy and simultaneous optical temperature monitoring can be achieved. The invention provides an effective temperature monitoring tool for photothermal therapy, the damage to normal tissues in tumor thermotherapy can be reduced, and significant application prospects in the field of biomedicine are achieved.
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Description

technical field

[0001] The invention belongs to the technical field of optical nano-probes, and in particular relates to a novel composite structure nano-optical probe material, a preparation method thereof, and an application in photothermal treatment of tumors and real-time microscopic temperature monitoring. Background technique

[0002] As an emerging cancer treatment, photothermal therapy has been extensively studied in recent years. Photothermal therapy is a process in which nano-optical absorbing materials are used to generate heat energy to kill cancer cells under the irradiation of light sources of specific wavelengths (usually near-infrared light). Compared with traditional hyperthermia methods (such as microwave hyperthermia, radiofrequency ablation, etc.), photothermal therapy is less invasive and easier to operate. In theory, it can achieve higher treatment accuracy and lower side effects. A promising approach to cancer therapy.

[0003] Due to the lack of goo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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