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Gold nanocomposite particle having plasma photothermal/photodynamic therapy performance, and preparation method thereof

A photodynamic therapy and photodynamic therapy technology, applied in the field of biomedical materials and nanomedicine, can solve the problems of reducing local tumor tissue reactive oxygen species, affecting the treatment effect of photodynamic therapy, self-destruction of photosensitizers, etc. Anti-tumor efficacy, favorable for popularization and application, stable effect of irradiation

Inactive Publication Date: 2013-09-25
XIAMEN UNIV
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  • Summary
  • Abstract
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  • Application Information

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Problems solved by technology

However, photosensitizers are prone to self-destruct under laser irradiation
In addition, once the photosensitizer is activated, photodynamic therapy will quickly lead to tissue hypoxia due to depletion of tissue oxygen and disturbance of tumor blood flow, thereby reducing the production of reactive oxygen species in local tumor tissue.
These problems affect the therapeutic effect of photodynamic therapy and largely limit its clinical application.

Method used

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  • Gold nanocomposite particle having plasma photothermal/photodynamic therapy performance, and preparation method thereof
  • Gold nanocomposite particle having plasma photothermal/photodynamic therapy performance, and preparation method thereof
  • Gold nanocomposite particle having plasma photothermal/photodynamic therapy performance, and preparation method thereof

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preparation example

[0040] 1. Preparation example: The chemical substances used in the following synthetic steps are commercially available.

[0041] A preparation method for gold nanocomposite particles, comprising the following steps:

[0042] 1) Add 3ml of 1% sodium citrate solution to 100ml of boiling 1.0mM chloroauric acid solution and stir rapidly.

[0043] 2) Add the cooled 50 μL of the citrate-stabilized seed solution to 10 mL of the 0.25 mmole chloroauric acid solution.

[0044] 3) Add 100μL of 0.5-3mM silver nitrate and 50μL of 0.1M ascorbic acid. The solution was stirred until its color changed from light red to dark blue.

[0045] 4) Add 10 μL of 10 mM HS-PEG-NH2 solution, and stir the reaction mixture at room temperature for 2 hours.

[0046] 5) The gold nanocomposite solution was centrifuged to remove excess HS-PEG-NH2 and resuspended in water.

[0047] 6) Add 2 mg of PEG-modified gold nanoparticles to 1 mL of dimethylformamide solution, add 3 mL of EDC at a ratio of 1:3, and re...

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Abstract

The invention discloses a gold nanocomposite particle having plasma photothermal / photodynamic therapy performance, and a preparation method thereof. The structure of the gold nanocomposite particle contains a gold nanoparticle used for the photodynamic therapy, a plasma photothermal therapy photosensitizer attached to the gold nanoparticle, and a hydrophilic polymer polyethylene glycol modifying the surface. The invention also relates to a use of the gold nanocomposite particle in the photodynamic / plasma photothermal collaborative therapy. The gold nanocomposite particle has the advantages of simple preparation, low price and substantial curative effect.

Description

technical field [0001] The invention relates to a gold nanocomposite particle with plasma photothermal / photodynamic therapy properties. The preparation method and the associated nanomaterials are used for the photodynamic / plasma photothermal synergistic therapy application of tumors and other diseases, belonging to biomedical materials and nano Medical field. Background technique [0002] According to the current trend of tumor incidence, the incidence of cancer worldwide will increase by 50% in 2020, and the number of new cancer patients worldwide will reach 15 million each year (the World Health Organization (WHO) recently published the "World Cancer Report"). Malignant tumors have become the main cause of death for Chinese residents, not only seriously endangering the health of our people, but also greatly increasing the burden of government and individual medical expenses. The efficient and specific diagnosis and treatment of tumors in my country are not only beneficial ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/02A61K47/48A61P35/00
Inventor 刘刚陈小元黄鹏王骁勇
Owner XIAMEN UNIV
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