Method for improving photothermal performance and photothermal stability of gold nanorod

A gold nanorod and stability technology, which is applied in the field of improving the photothermal stability of gold nanorods, and can solve problems such as stability and poor photothermal performance

Active Publication Date: 2016-11-23
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] One object of the present invention is to provide a method for improving the photothermal performance and photothermal stability of gold nanorods, which can solve the problems of poor stability and photothermal performance of gold nanorods as a near-infrared responsive photothermal material

Method used

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  • Method for improving photothermal performance and photothermal stability of gold nanorod
  • Method for improving photothermal performance and photothermal stability of gold nanorod
  • Method for improving photothermal performance and photothermal stability of gold nanorod

Examples

Experimental program
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Effect test

Embodiment 1

[0061] Prepare a gold nanocluster (GNC) solution coated with bovine serum albumin (BSA):

[0062] 5 mL of 10 mM HAuCl 4 Mix well with 5mL of BSA with a concentration of 50mg / mL, and fully stir at 37°C. After 2min, quickly add 0.5mL of freshly prepared NaOH with a concentration of 1M, and continue to stir at 37°C. After 12h of reaction, the solution is orange-red. Put it in a dark box and irradiate it with 365nm light to see the red fluorescence, that is, the synthesis of GNC is completed.

Embodiment 2

[0064] Ascorbic acid (AA)-reduced gold nanorods (GNRs) solutions were prepared by seed growth method:

[0065] (1) Preparation of gold seeds: Add 5 mL of 0.5 mM chloroauric acid (HAuCl) to 5 mL of 0.1 M CTAB solution 4 ) aqueous solution, then mix well, and then add 14mL of ultrapure water; quickly add 0.5mL of 0.1M ice-cold sodium borohydride (NaBH 4 ) solution, the solution turned deep purple, continued to stir vigorously for 2 minutes, and then placed it in water at 28°C for 3 hours, and the NaBH that did not participate in the reaction 4 All were hydrolyzed to obtain a gold seed solution for subsequent use;

[0066] (2) Preparation of gold nanorod solution: 5mL of 1mM chloroauric acid (HAuCl 4 ) and 5mL of 0.2M cetyl ammonium bromide (CTAB) were thoroughly mixed, followed by adding 200uL of 4mM silver nitrate (AgNO 3 ) solution, 70uL of 100mM ascorbic acid (AA), stirred vigorously, the solution changed from yellow to colorless, and finally, added 120uL of the gold seed ...

Embodiment 3

[0068] Preparation of bovine serum albumin-coated gold nanorods (BSA-GNRs): Take 500uL of the gold nanorod solution prepared in Example 2 in a 1.5mL centrifuge tube, place it on a metal bath and control the temperature at 37°C, inject 20mg / mL of 250ul of BSA solution, mix well; add water to bring the total volume of the solution to 1mL, stand still for 30min, so that BSA and gold nanorods can fully react; centrifuge the solution at 2000rpm for 10min, twice; disperse the precipitate into 1mL of pure Store in water at 4°C, protected from light;

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Abstract

The invention provides a modified gold nanorod. The surface of the modified gold nanorod is wrapped by gold nanocluster which is wrapped by bovine serum protein (BSA), so as to form a novel nanometer composition. The composition is exposed under the irradiation of near infrared light and used for exploring the photothermal performance and photothermal stability. After irradiation of near infrared light for many times, the optical property and shape of the gold nanocluster-gold nanorod composition have no obvious change, and the temperature is obviously increased. As a comparison, the identical gold nanorod and the bovine serum protein wrapped gold nanorod are sequentially used as stability control experiments. In addition, the photothermal performance and the glue stability of the gold nanocluster-gold nanorod composition have extremely good reproducibility. Therefore, the nano composition capable of improving the photothermal property and the photothermal stability is very suitable for further biological applications, such as remote sensing, bioimaging and photothermal therapy.

Description

technical field [0001] The invention relates to a method for improving the photothermal stability of gold nanorods. It specifically relates to a method for improving the thermal performance, photothermal stability and biocompatibility of gold nanorods by complexing with gold nanoclusters wrapped by bovine serum albumin through electrostatic interaction. Background technique [0002] Near-infrared light refers to electromagnetic waves with wavelengths in the near-infrared region (780nm-2526nm). Compared with ultraviolet light and visible light, near-infrared laser irradiation can penetrate deep into the subcutaneous tissue and cause minimal damage to surrounding healthy tissue. And many nanoparticles, such as copper sulfide nanocrystals, gold nanorods, gold triangles, etc., have unique surface plasmon resonance absorption in the near-infrared wavelength region. Based on this special optical property, these nanomaterials can generate a certain amount of heat after being irra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y40/00
CPCB82Y40/00B22F9/24B22F1/07
Inventor 袁菁苏鑫
Owner CAPITAL NORMAL UNIVERSITY
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