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Small-size gold nanorod and preparation method and applications thereof

A gold nanorod, small size technology, applied in the field of nanomaterials, can solve the problems of gold nanorod size, aspect ratio and yield, which limit the large-scale preparation of gold nanorods, and poor dispersion of gold nanorods, etc. To achieve the effect of easy promotion, uniform size and good monodispersity

Active Publication Date: 2016-06-01
武汉中科先进材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the seed crystal growth method proposed by Murphy et al. is widely used at present, but this method is complicated to operate and takes a long time. There are many and complicated factors affecting the size, aspect ratio and yield of gold nanorods, and it has a greater impact on gold seeds. High requirements limit the large-scale preparation of gold nanorods
The Chinese application with the publication number CN103722177A adopts a seedless one-step method to synthesize gold nanorods. Although this method is easier to operate than the seed crystal growth method, the diameter of the gold nanorods obtained by this method is about 50nm, which is relatively large. The preparation process involves multiple ultrasonic operations, and the operation is cumbersome. Even after multiple ultrasonic operations, the dispersion of the prepared gold nanorods is still poor.

Method used

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  • Small-size gold nanorod and preparation method and applications thereof
  • Small-size gold nanorod and preparation method and applications thereof
  • Small-size gold nanorod and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A preparation method of small-sized gold nanorods, comprising the following steps:

[0052] Add 1mL chloroauric acid aqueous solution (5mM) to a 50mL test tube or beaker, then add 5mL cetyltrimethylammonium bromide aqueous solution (0.2M), after slight stirring, add 4.5mL ultrapure water, 500μL oleic acid Sodium aqueous solution (0.1M), stir slowly and evenly, add 250 μL silver nitrate aqueous solution (4mM), stir gently again, add 8 μL 37% concentrated hydrochloric acid, adjust the pH of the reaction system to 1, stir gently, add 56 μL ascorbic acid aqueous solution (0.1M), slightly After stirring, after the solution became colorless, 15 μL of frozen sodium borohydride aqueous solution (0.01M) was quickly added, and then stood in a 35°C incubator for 3 hours to obtain small-sized gold nanorods with a diameter of 6±1nm.

[0053] The test properties of the small-sized gold nanorods prepared above are as follows:

[0054] figure 1 It is the ultraviolet-visible-near-infr...

Embodiment 2

[0057] A preparation method of small-sized gold nanorods, comprising the following steps:

[0058] Add 500 μL chloroauric acid aqueous solution (5mM) to a 50mL test tube or beaker, then add 5mL cetyltrimethylammonium bromide aqueous solution (0.2M), after slight stirring, add 5mL ultrapure water, 100μL sodium oleate Aqueous solution (0.1M), stir slowly and evenly, add 200 μL silver nitrate aqueous solution (4mM), stir gently again, add 8 μL 37% concentrated hydrochloric acid, adjust the pH of the reaction system to 1, stir gently, add 56 μL ascorbic acid aqueous solution (0.1M), stir gently After the solution turned colorless, 15 μL of frozen sodium borohydride aqueous solution (0.01M) was quickly added, and then left to stand in a 35°C incubator for 3 hours to obtain small-sized gold nanorods with a diameter of 8±1nm.

[0059] The test properties of the small-sized gold nanorods prepared above are as follows:

[0060] figure 1 It is the ultraviolet-visible-near-infrared abs...

Embodiment 3

[0063] A preparation method of small-sized gold nanorods, comprising the following steps:

[0064] Add 1mL chloroauric acid aqueous solution (5mM) into a 50mL test tube or beaker, take 5mL cetyltrimethylammonium bromide aqueous solution (0.2M) into it, stir gently, then add 4.5mL ultrapure water, 500μL oil Aqueous sodium nitrate solution (0.1M), stir slowly and evenly, add 150 μL silver nitrate solution (4 mM), stir slightly, add 8 μL 37% concentrated hydrochloric acid, adjust the pH of the reaction system to 1, stir slightly, add 56 μL aqueous ascorbic acid (0.1M), again Stir gently, and after the solution turns colorless, 15 μL of frozen sodium borohydride aqueous solution (0.01M) is quickly added immediately, and then left to stand in a 35°C incubator for 3 hours to obtain small-sized gold nanorods with a diameter of 5±1nm.

[0065] The test properties of the small-sized gold nanorods prepared above are as follows:

[0066] figure 1 It is the ultraviolet-visible-near-infr...

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Abstract

The invention discloses a small-size gold nanorod and a preparation method and applications thereof. The growth reaction is adjusted by utilization of cationic-anionic surfactants as a mixed growth template, and synthesis of the small-size gold nanorod with the diameter of 5-9 nm is achieved through the non-gold-seed one-step method. The diameter and the length-diameter ratio of the small-size gold nanorod are adjusted through changes of the mole ratio of the chloroauric acid to the cationic-anionic surfactants to the silver nitrate. Operation is simple, consumed time is short, repeatability is good, and the small-size gold nanorod good in monodispersity and uniform in size can be obtained with no ultrasound in the preparation process. The diameter of the small-size gold nanorod is 5-9 nm, the size is small, and the ratio of the absorption value of a longitudinal surface plasma resonance absorption peak to the absorption value of a transverse surface plasma resonance absorption peak of the small-size gold nanorod is 2.5-5.5. The prepared small-size gold nanorod can be applied to the fields of preparation of photo-thermal treatment drugs, optical mark drugs, sensors and the like.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a small-sized gold nanorod and its preparation method and application. Background technique [0002] Gold nanorods are rod-shaped gold nanoparticles with a size ranging from several nanometers to hundreds of nanometers. It can cause changes in the position and intensity of its SPR absorption peak, which can be used in the detection of single molecules, low-concentration molecules and ions. At the same time, it has a good photothermal effect, which can convert the absorbed near-infrared light into heat energy. The unique physical and chemical properties make gold nanorods play an important role in the fields of optoelectronics, sensors, medical imaging and cancer photothermal therapy. [0003] When the aspect ratio of gold nanorods (the length ratio of the longitudinal and transverse parts) is constant, the smaller the size of the gold nanorods, the higher the luminous eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/00B22F9/24B82Y40/00
Inventor 喻学锋黄浩唐思莹
Owner 武汉中科先进材料科技有限公司
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