Nickel doped copper sulfide nano material as well as preparation method and application thereof

A nanomaterial, copper sulfide technology, applied in the field of medical nanomaterials to achieve the effect of increasing the ability of magnetic resonance imaging

Active Publication Date: 2015-04-29
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] More and more studies have found that the development of nanomaterials with imaging and therapeutic functions is of great significance to the individualized treatment of tumors. However, how to prepare nanomaterials with small particle size, uniform particle size and dispersed nanoparticles is still to be solved.

Method used

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  • Nickel doped copper sulfide nano material as well as preparation method and application thereof
  • Nickel doped copper sulfide nano material as well as preparation method and application thereof
  • Nickel doped copper sulfide nano material as well as preparation method and application thereof

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Embodiment 1

[0152] combine figure 1 The preparation process flowchart of nickel-doped copper sulfide nano-material shown, the invention provides a kind of preparation method of nickel-doped copper sulfide nano-material, comprises the following steps:

[0153] (1) Preparation of S precursor: Add S powder (calculated as S element, 2 mmol) into a 10 mL glass bottle in the glove box, then add oleylamine (8 mL, density 0.813 g / mL); Cap the vial and remove from the glove box, sonicate until S is completely dissolved;

[0154] (2) CuCl 2 (according to Cu element, the addition amount is 1.6mmol), NiCl 2 (Based on Ni element, the addition amount is 0.4mmol) and oleylamine (4mL, density 0.813g / mL) were added to a 25mL three-neck round bottom flask, vacuumed for 30min, and then passed through N 2 and heated to 180°C, then inject the S precursor solution obtained in step (1) into the solution in the reactor (injection speed is 4ml / s), cool down to 150°C and keep warm for 0.5 hours, then cool to ro...

Embodiment 2

[0167] (1) Preparation of S precursor: In the glove box, thiourea (according to S element, the addition amount is 2mmol) is added in the 10mL glass bottle, then adds oleic acid (20mL); Take it out from the glove box, and sonicate until S is completely dissolved;

[0168] (2) Copper nitrate (according to Cu element, the addition amount is 1.998mmol mmol), nickel nitrate (according to Ni element, the addition amount is 0.002mmol) and oleic acid (10mL) were added in a 25mL three-neck round-bottomed flask, pumped Vacuum for 45min, then pass N 2 and heated to 160°C, then inject the S precursor solution obtained in step (1) into the solution in the reactor (injection speed is 2.5ml / s), cool down to 120°C and keep it warm for 20 minutes, then cool to room temperature;

[0169] (3) After the reaction product is cooled to room temperature, centrifuge at 3000g / min to remove large particles, then add absolute ethanol to precipitate for 5 minutes according to 3 times the volume of the re...

Embodiment 3

[0171] (1) Preparation of S precursor: Add sodium thiosulfate (according to S element, the addition amount is 5mmol) into a 25mL glass bottle in the glove box, and then add oleylamine and oleic acid (volume ratio is 8:2) The mixed solution (12.5mL); Then cap the glass vial and take it out from the glove box, sonicate until S dissolves completely;

[0172] (2) Copper sulfate (according to Cu element, the addition amount is 1mmol), nickel sulfate (according to Ni element, the addition amount is 4mmol) and a mixed solvent of oleylamine and oleic acid (volume ratio is 8:2) (5mL ) was added to a 25mL three-neck round bottom flask, vacuumed for 15min, and then passed through N 2 and heated to 220°C, then inject the S precursor solution obtained in step (1) into the solution in the reactor (injection speed is 10ml / s), cool down to 130°C and keep warm for 12 minutes, then cool to room temperature;

[0173] (3) After the reaction product is cooled to room temperature, centrifuge at 20...

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Abstract

The invention provides a nickel doped copper sulfide nano material. The chemical general formula of the nickel doped copper sulfide nano material is Cu1-xNixS, wherein CuS refers to a substrate, Ni<2+> refers to doping ions, and the value range of x is that x is larger than 0 and is smaller than or equal to 0.8; the nickel doped copper sulfide nano material provided by the invention is a multifunctional nano material and simultaneously has a magnetic resonance imaging function and a photothermal therapy effect, so that the nickel doped copper sulfide nano material can be used as a magnetic resonance imaging probe and a photothermal therapy reagent and is a nano material integrating detection and therapy. The invention further provides a preparation method and an application of the nickel doped copper sulfide nano material.

Description

technical field [0001] The invention relates to the field of medical nanomaterials, in particular to a nickel-doped copper sulfide nanomaterial and its preparation method and application. Background technique [0002] In recent years, the morbidity and mortality of cancer have been increasing, and it has become one of the most challenging medical problems in the 21st century. Early investigation, early diagnosis, and early treatment are effective ways to treat tumors. However, normal tissue is often indistinguishable from early diseased tissue. Among the existing imaging techniques, magnetic resonance imaging can display physiological and anatomical details to a certain extent without ionizing radiation. It is the most effective non-invasive imaging technique and is widely used in clinical medicine. Using magnetic resonance imaging to image the tumor can judge the main outline of the tumor before the operation and achieve the purpose of preoperative guidance. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/06A61K49/12A61P35/00C01G53/11
Inventor 蔡林涛高笃阳张鹏飞吴亚运刘朋胡德红盛宗海龚萍
Owner SHENZHEN INST OF ADVANCED TECH
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