Black phosphorus quantum dot composite material and preparation method and application thereof

Abstract

The invention provides a black phosphorus quantum dot composite material comprising a black phosphorus quantum dot, positive ions modified on the surface of the black phosphorus quantum dot and polyethylene glycol or polyethylene glycol derivatives. The positive ions comprise the metal positive ions or the ammonium ions. The positive ions are combined with the black phosphorus quantum dot through electrostatic force, and the pieces of polyethylene glycol or the polyethylene glycol derivatives are combined with the black phosphorus quantum dot through Van der Waals force. According to the black phosphorus quantum dot composite material, the positive ions are combined with the black phosphorus quantum dot through the electrostatic force, so that the oxidation resistance ability of the positive ions is improved greatly, and the pieces of polyethylene glycol or the polyethylene glycol derivatives are combined with the black phosphorus quantum dot through the Van der Waals force so that the black phosphorus quantum dot can be stably dispersed in water. The invention provides a preparation method of the black phosphorus quantum dot composite material in the second aspect. The method is simple and easy to operate. The black phosphorus quantum dot composite material can be used for preparing photoacoustic imaging drugs, or photothermal therapy drugs, or photodynamic therapy drugs or drug-loading targeted therapy drugs.

Description

Technical field [0001] The invention relates to the field of quantum dot materials, in particular to a black phosphorous quantum dot composite material and a preparation method and application thereof. Background technique [0002] Black phosphorous quantum dots are used in the field of biomedicine (such as photoacoustic imaging, photothermal therapy, photodynamic therapy, and drug-loaded therapy) because of their strong light absorption and photothermal conversion efficiency, high biocompatibility, and no long-term biological toxicity. There is a breakthrough application in it. Compared with materials commonly used in the biomedical field (including metal nanoparticles, carbon-based nanomaterials, and other two-dimensional materials such as titanium disulfide and molybdenum disulfide), black phosphorous quantum dots have higher light-to-heat conversion efficiency The most important thing is that the black phosphorus quantum dots have high biocompatibility and can be degraded in...

AI Technical Summary

Problems solved by technology

[0003] Biomedical applications are mostly carried out in water systems. Black phosphorus quantum dots are currently facing two major challenges in biomedical applications: one is that black phosphorus quantum dots are extremely unstable and are quickly oxidized in water, so black phosphorus quantum dots enter The biological body is often degraded before it can play a role, which is what we don't want to see when we apply it; the second is that the dispersibility of black phosphorus quantum dots in aqueous solution is relatively poor, and they cannot be uniformly dispersed in cell culture fluid , hindering its normal application

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