Shape and size controllable gold nanoparticles and preparation method and application thereof

A technology of nano-gold particles and size, which is applied in the field of preparation of nano-gold particles, can solve the problems of poor patient compliance, high probability of surgical recurrence, damage to normal cells, etc., and achieve good stability, simple and feasible preparation process, and good water solubility Effect

Active Publication Date: 2019-03-01
SUZHOU INSTITUE OF WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the challenges of poor patient compliance during chemotherapy, high recurrence rate of surgery, and da

Method used

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  • Shape and size controllable gold nanoparticles and preparation method and application thereof
  • Shape and size controllable gold nanoparticles and preparation method and application thereof
  • Shape and size controllable gold nanoparticles and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Synthesis of 50nm and 100nm spherical gold nanoparticles

[0041] 1) Preparation of seeds

[0042] Weigh a certain amount of sodium citrate trihydrate and dissolve it in 150mL of first-class water to make 2.2mmol / L, add HAuCl 4 (Concentration 25mmol / L) The solution was vigorously stirred in a water bath at 110°C for 15min. It can be observed that the color of the solution changes from yellow to blue-gray, then turns to pink within 10 minutes, and turns to wine red in about 30 minutes.

[0043] 2) Preparation of growth solution

[0044] Take 53mL of primary water, 2mL of sodium citrate (60mmol / L) and HAuCl 4(25mmol / L) solution was made into a solution and heated to 90°C, 55mL of the seed solution cooled to 90°C was taken out and mixed with it, and reacted in a 95°C water bath for a certain period of time. The size of nano gold particles increases accordingly, and spherical gold nanoparticles of 50nm and 100nm can be formed.

Embodiment 2

[0045] Embodiment 2: the synthesis of 50nm and 100nm cubic nano gold

[0046] 1) Preparation of 50nm cubic seeds

[0047] First, the HAuCl 4 (0.01mol / L) solution and cetyltrimethylammonium bromide were added to 10mL of first-grade water and shaken for 5min. It was observed that the color of the solution changed from light yellow to orange. Then add freshly prepared NaBH at 25°C 4 (0.1mol / L) solution. The color of the solution was observed to change from orange to brown immediately after the addition.

[0048] 2) Preparation of 50nm cubic growth solution

[0049] Add HAuCl to cetyltrimethylammonium bromide aqueous solution at room temperature 4 (0.01mol / L). Then add the freshly prepared ascorbic acid (0.1mol / L) aqueous solution to the mixture solution, the color of the solution changes from orange to colorless immediately, drop the prepared seeds into the colorless liquid with a 5μL micro syringe, and react for 12-14h , it can be seen that the solution is dark red.

[0...

Embodiment 3

[0056] Embodiment 3: Synthesis of 50nm and 100nm star-shaped gold nanoparticles

[0057] 1) Preparation of seeds

[0058] HAuCl 4 (0.01mol / L) and trisodium citrate (0.02mol / L) were added to primary water, and the total volume of the mixed solution was 20mL. Then add 60 μL of sodium borohydride NaBH prepared with ice water under stirring 4 solution (0.1mol / L). Add NaBH 4 Afterwards, the solution turned pink immediately, and reacted in the dark for 2 hours to form golden spherical seeds.

[0059] 2) Preparation of growth solution

[0060] Weigh cetyltrimethylammonium bromide and dissolve it in 9.5mL of first-class water, then add HAuCl 4 (0.01mol / L). The solution turned from yellow to orange. AgNO was first added under vigorous stirring conditions 3 (0.01mol / L), and then add ascorbic acid (0.1mol / L). The orange solution turned into a clear colorless solution. Subsequently, a certain amount of the above seed solution was added to the colorless solution to react for a c...

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Abstract

The invention discloses shape and size controllable gold nanoparticles and a preparation method and application thereof. The water-soluble and monodispersed gold nanoparticles with different shapes and sizes are synthesized by adopting a seed growth method, and the shapes comprise the spherical shape, the bar shape, the dumbbell shape, the bipyramid shape, the cube shape and the star shape with abranch structure. The series of nanogold with different sizes can be obtained in the mode of changing a seed solution by taking ascorbic acid or sodium borohydride or hydroquinone as a reducing agent,taking hexadecyl trimethyl ammonium bromide as a cationic surface active agent and a stabilizing agent and taking sodium citrate as a reducing agent and a stabilizing agent, fine control over the shape and the size of the nanogold is achieved, the high yield, the high purity and the good water solubility are achieved, no biotoxicity is generated, and a purification technology is simple. The shapeand size controllable gold nanoparticles can be applied to the fields of photoacoustic imaging, photothermal therapy and biosensing.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and relates to tumor imaging, photothermal therapy and the like in the field of biomedicine, in particular to a preparation method of a series of nano gold particles of different shapes and sizes. Background technique [0002] Cancer has become the primary enemy that endangers human health. Traditional treatment methods include chemotherapy, radiation therapy, and surgical resection. However, due to challenges such as poor patient compliance during chemotherapy, high recurrence rate during surgery, and damage to normal cells by radiotherapy, new and effective cancer treatment strategies are urgently needed to be studied. Targeted therapy is a new type of therapy that has gradually developed since the late 1990s and has achieved significant results in the treatment of certain types of cancer. The use of nanomaterials as drug or gene delivery carriers has the advantages of improv...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00A61K41/00A61K49/22A61P35/00
CPCA61K41/0052A61K49/225A61P35/00B82Y40/00B22F9/24
Inventor 肖玉玲洪学传吴华萍唐琳曾小东
Owner SUZHOU INSTITUE OF WUHAN UNIV
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