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Method for researching pharmacodynamic relationship of various medicinal components of compound thromboxane preparation

A technology of compound Xueshuantong and medicinal materials, which is applied in the field of research on the relationship between the medicinal effects of various medicinal materials in compound Chinese medicine prescriptions, can solve the problems of lack of connotation of the prescription, contribution of medicinal effects, primary and secondary, and unclear interaction relations, etc., and achieve good practical value Effect

Inactive Publication Date: 2018-02-27
SUN YAT SEN UNIV
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Problems solved by technology

However, at present, the medicinal effect contribution, primary and secondary, and interaction relationship of each medicinal material in the compound Xueshuantong preparation are still unclear, and the connotation of its composition is still lacking the support of modern scientific data

Method used

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  • Method for researching pharmacodynamic relationship of various medicinal components of compound thromboxane preparation
  • Method for researching pharmacodynamic relationship of various medicinal components of compound thromboxane preparation
  • Method for researching pharmacodynamic relationship of various medicinal components of compound thromboxane preparation

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Embodiment

[0030] Example: The contribution, primary and secondary, and interaction relationship of Sanqi, Danshen, Astragalus, and Scrophulariaceae in compound Xueshuantong preparations

[0031] 1. Materials

[0032] (1) Animals: 180 SPF (specific-pathogen free) male SD (Sprague Dawley) rats, weighing 180-220g, animal quality certificate number: 44007200034125; the animals were provided by the Guangdong Provincial Medical Experimental Animal Center, and the animal facility license Certificate number: SCXK-(Guangdong) 2013-0002.

[0033] (2) Instruments: Roche P 800 automatic biochemical analyzer (Roche, MODULAR P800), Mindray BC-5800 automatic blood cell analyzer (Mindray, BC-5800), low temperature centrifuge (Eppendorf, 5430R), 100,000 points One electronic balance (Sartorius, BP211D), ultra-low temperature refrigerator (Haier, BCD-568W), HH-4 digital display constant temperature water bath (Guohua Electric Co., Ltd., HH-4), DG5033A microplate reader (Nanjing Huadong Electronics Group...

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Abstract

The present invention discloses a method for researching the pharmacodynamic relationship of various medicinal components of a compound thromboxane preparation. In the method, the mass percentage of each herbal medicine in the formula of the compound thromboxane preparation is taken as a variable, a uniform design method is used to prepare multiple difference samples with different proportions ofmedicinal materials, and at the same time, multiple missing samples of prescription medicinal materials is prepared; through pharmacodynamics research, the pharmacodynamic data of each difference sample and missing sample of the medicinal materials are obtained; and a variety of statistical methods are used to analyze the relationship between medicinal materials and efficacy in multiple samples, and the contribution, primary and secondary effects and interactions of each medicinal material are determined. The present invention discloses for the first time a method for researching the contribution, primary and secondary effects and interactions of each medicinal material in the compound thromboxane preparation, provides a basis for clarifying the compatibility rule of the scientific constituents and screening the optimal proportion of the constituents, and provides more scientific and more complete modern scientific data support for the clinical application of the compound thromboxane preparation.

Description

technical field [0001] The invention relates to a method for researching the effect relationship of various medicinal materials in compound Chinese medicine prescriptions Background technique [0002] Compound traditional Chinese medicine is composed of several traditional Chinese medicines in accordance with the law of "junchenzuoshi" and appropriate dosage. It often has a lower dosage threshold and a wider therapeutic window, which well reflects the clinical characteristics of traditional Chinese medicine for disease prevention and treatment. The medicinal materials in the compound traditional Chinese medicine preparation range from five or six flavors to as many as twenty flavors, and the efficacy of them is not simply the sum of the effects of single medicinal materials. In recent years, computer data mining technology has gradually been widely used in the analysis of prescription rules of traditional Chinese medicine. The traditional Chinese medicine inheritance auxilia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
CPCG16C20/50
Inventor 姚宏亮刘宏苏薇薇李沛波吴忠王永刚彭维
Owner SUN YAT SEN UNIV
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