97 results about "Physical stress" patented technology

A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a biological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.

The present invention is a surface mount component carrier comprised of a disk of insulating material having at least two apertures. The disk is substantially covered by a metalized ground surface and includes at least two conductive pads surrounding the apertures, and insulating bands which surround each conductive pad. The insulating bands separate and electrically isolates the conductive pads from the metalized ground surface. A surface mount component, such as a differential and common mode filter, is positioned lengthwise between the two conductive pads and operably coupled to the carrier. Once the surface mount component is coupled to the carrier, the combination can be manipulated, either manually or through various types of automated equipment, without subjecting the surface mount component to mechanical and physical stresses normally associated with the handling of miniature components. The carrier also provides the added benefit of improved shielding from electromagnetic interference and over voltage dissipation due to the surface area of the metalized ground surface. The same concept for the above described carrier is also incorporated into several alternate embodiments, either independently or embedded within electronic connectors.

Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence:(a) administering to a subject about 3 mCi Tl201 thallous chloride;(b) allowing said subject to rest;(c) radioimaging a heart of said subject;(d) subjecting said subject to a physical stress;(e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and(f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

A useful method of verifying the integrity of a cryptosystem involves using erroneous outputs to obtain secret information. In certain signature schemes which use the Chinese Remainder Theorem, a correct signature of a message and an erroneous signature of the same message permit the modulus to be easily obtained. If the content of the message is known, such cryptosystems may be cracked with only an erroneous signature of the message. Certain other authorization schemes may be cracked by analyzing a number of erroneous outputs caused by a particular type of error called a “register fault.” A security expert or cryptosystem designer may intentionally induce a tamper proof device generate a faulty computation by subjecting the device, such as a smart card, to physical stress, such as certain types of radiation, atypical voltage levels, or a higher clock rate than the device was designed to accommodate. Cryptosystems should be impervious to the attacks described herein. If not, the system should be modified or discarded.

An improved platinum and method for manufacturing the improved platinum wherein the platinum having a fractal surface coating of platinum, platinum gray, with a increase in surface area of at least 5 times when compared to shiny platinum of the same geometry and also having improved resistance to physical stress when compared to platinum black having the same surface area. The process of electroplating the surface coating of platinum gray comprising plating at a moderate rate, for example at a rate that is faster than the rate necessary to produce shiny platinum and that is less than the rate necessary to produce platinum black. Platinum gray is applied to manufacture a fuel cell and a catalyst.

The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.

Disclosed is a stable pharmaceutically acceptable formulation containing a pharmaceutically acceptable amount of a protein. Also disclosed are methods for preparing such formulations and methods for inhibiting protein aggregate formation induced by physical stresses associated with processing, manufacture, shipping, and storing protein formulations, particularly freeze / thaw stress.

A portable, unitary, lightweight, weather-proof support mat to reduce physical stress on a user caused by standing, sitting or kneeling on a hard surface for prolonged periods. The support mat provides a non-slip surface and an integral handle opening. The support mat is manufactured of rubber or other resilient material and may be provided in a variety of shapes and sizes.

A flexible electric heating mat includes a grounding substrate sheet arranged in relation to electrical conductors and resistive elements of an electric heater element so as to provide safe and reliable operation of the mat in environments in which the mat will be subjected to moisture and physical stresses.

A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.

The invention discloses a method for determining a power transmission line reinforcing scheme by comprehensive fault rate and economic efficiency evaluation. The method includes adopting the general extreme value theory to model historical ice coating data of an area to obtain probability of ice disasters of the area with specific ice coating thickness; establishing a circuit fault rate function based on physical stress analysis of power transmission lines according to the metal deformation theory, and establishing a fuzzy fault rate model of the lines by virtue of fuzzy offline rate; comprehensively considering the probability of the ice disasters in the area with the specific ice coating thickness and the fuzzy fault rate of the lines in the area to obtain comprehensive fault rate of the lines; calculating differential 'detraction' benefits by means of the comprehensive fault rate, establishing an economic efficiency evaluation index system of differential planning on this basis, and determining the sectional reinforcing scheme of the lines. The method for determining the power transmission line reinforcing scheme by the comprehensive fault rate plays an important role in guiding workout of the line-difference sectional reinforcing scheme in the differential planning and has great significance in improving anti-disaster ability of the power grid.

The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on the cell. Trauma can reduce the motility, fertility, viability and overall integrity of the sperm and reduce the ability to fertilize, produce an embryo and a healthy offspring. The present invention relates to novel compounds that can be added to the sperm cell sample to reduce the traumatic effects of physical stress during mild as well as extensive sperm cell processing, methods of using the compounds in standard sperm processing procedures, the end products made from these methods including sperm and embryos, as well as methods of using those end products in assisted reproductive biology techniques in animals.

A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bi-polar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into the extracellular space without denaturing proteins so as to enable animmunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

The invention relates to the use of extended surface aggregates (ESAs) comprising at least one first amphipathic component, which is a basic aggregate-forming component, and at least one second amphipathic component, which decreases aggregate sensitivity to physical stress, including stress created by enforced passage of said ESAs through pores with an average pore diameter at least 50% smaller than the average diameter of the ESAs before said passage, such that the average ESA diameter change induced by such physical stress is reduced by 10% or more, compared to the diameter change induced by such stress in a reference system comprising just the first or just the second aggregate component, in the manufacture of a pharmaceutical preparation for enduring treatment of pathological mammalian skin conditions, including skin irritation, skin inflammation and / or skin damage after topical application, for modifying skin pigmentation and / or for treatment of skin itch.

A low cost micro-electronic package for MEMS applications includes a package substrate, a MEMS device and a buffer insert which is placed between the MEMS device and the package substrate. The buffer insert has a coefficient of thermal expansion (CTE) which is compatible with the material of the MEMS device and is sufficiently rigid to isolate the MEMS device from thermal, mechanical and other physical stresses applied to the package substrate. In an embodiment, the package is formed as an integrated device which includes both the MEMS device and a signal conditioning integrated circuit, potentially found in the same die. The substrate insert may be made of a material having a CTE value compatible with silicon (Si), such as Kovar, Invar, or an appropriate ceramic material or the like.

The present invention relates to a method of testing Bacopa monnieri response to abiotic stress factors and for testing bioactivity of natural, synthetic and semisynthetic compounds using Bacopa monnieri plant, which comprises growing the said plant and plant parts aseptically in MS 0 basal medium with agar in microcentrifuge tubes by adding the compounds to be tested either to the culture media or by spraying the said compounds on the plant or plant parts or on the said medium to detect the distinct morphological and cytological responses.

A carrying apparatus provides a self-powered, rechargeable, technologically adaptable transport vehicle, such as a stroller. The apparatus includes efficient seating and storage capacities for efficiency items, such as pertinent baby supplies. Because the apparatus is self-powered, the physical stress of carrying at least one item is reduced. Furthermore, the apparatus uses technology to maintain perpetual power for operation, and to regulate and monitor the propulsion of the apparatus during transport. The apparatus may be pushed or pulled in multiple directions at varying velocities. The apparatus includes braking and accelerating capacities. A frame portion supports a seat portion, such as a buckled baby seat; a storage portion, such as a cargo mesh. A rechargeable power source powers a motor that turns a drive shaft for propulsion. Brakes position at the wheels. A control portion provides a display and levers for accelerating and decelerating.

The invention provides for containers having grips and structure. More specifically, such ergonomic grips and structure enable a human's ability to lift and hold such containers easily and without significant strain on a human's body resulting from physical stress of a the container itself and / or a weighted load within the container.

The disclosed embodiments relate to a system for use with a model railroad which models, for one or more of the model rail cars, the actual sounds made by the real rail car(s) modeled thereby and having certain characteristics, including general operational characteristics, wear, age, defects, etc., when subjected to various physical stresses / actions during operation. The disclosed system senses similar physical stresses / actions as applied to a model of the rail car during modeled operation thereof and generates corresponding simulations of the actual sounds which would be made by the actual rail car under similar operational conditions, wherein the generation of the simulated sounds may account for the characteristic of the rail car (age, wear, defects), regardless of whether the model of the rail car models those characteristics.

Organic electronic devices, compositions, and methods are disclosed that employ electrically conductive nanowires and conducting materials such as conjugated polymers such as sulfonated regioregular polythiophenes which provide high device performance such as good solar cell efficiency. Devices requiring transparent conductors that are resilient to physical stresses can be fabricated, with reduced corrosion problems.

The invention provides for containers having grips and structure. More specifically, such ergonomic grips and structure enable a human's ability to lift and hold such containers easily and without significant strain on a human's body resulting from physical stress of a the container itself and / or a weighted load within the container.

The side-mounted, biomechanically designed lifting device maximizes the lifting capability of human anatomy. A harness with a shoulder pad crosses the user's body diagonally. The load is supported by an adjustable load strap at the user's side from a support ring attached to the harness. One end of the support strap is attached to the harness and the other to a lifting handle. With this device and method heavy and awkward loads like plywood and drywall may be carried and manipulated easily. The side-mounted lifting harness causes the user to lean away from the load. This transfers the weight of a load to a point near the ground, below the vertical center of gravity of the user and between the lifter's feet. There is significant biomechanical advantage to this load configuration. One person can carry heavy, awkward loads safely and quickly with a minimum of physical stress.

This invention provides methods for treating and for inhibiting the onset of cancer in a subject comprising administering an agent that inhibits the ability of Sir2α to inhibit p53-dependent apoptosis. This invention also provides a related method for inducing the death of a cell. This invention further provides a method for decreasing the amount of damage to a subject's cells caused by physical stress comprising administering agent that increases the amount of Sir2α in the subject's cells and / or the ability of Sir2α to inhibit p53-dependent apoptosis in the subject's cells. This invention further provides related methods for prolonging the life-span of a subject, decreasing the amount of damage to a cell caused by physical stress, and prolonging the life-span of a cell. Finally, this invention provides two articles of manufacture for performing the instant methods.

A connector assembly and a method of utilizing a connector assembly to enhance performance, improve reliability and provide ease of assembly of electronic equipment are presented. The connector assembly comprises a rigid bracket capable of holding multiple connectors. The bracket acts as a common ground for all of the connectors. The connector assembly has multiple legs and connector conductors that insert into corresponding apertures on a PCB. The legs of the connector assembly are configured to permit the placement of circuit traces on the PCB in the spaces between the legs. After placement of the connector assembly onto the PCB, soldering or other techniques may be used to secure the connector assembly to the board and to connect the proper circuits to the connectors. Because the connectors are installed on the rigid bracket, repeated physical stresses induced on the ports or jacks do not affect the integrity of the PCB.

The side-mounted, biomechanically designed lifting device maximizes the lifting capability of human anatomy. A harness with a shoulder pad crosses the user's body diagonally. The load is supported by an adjustable load strap at the user's side from a support ring attached to the harness. One end of the support strap is attached to the harness and the other to a lifting handle. With this device and method heavy and awkward loads like plywood and drywall may be carried and manipulated easily. The side-mounted lifting harness causes the user to lean away from the load. This transfers the weight of a load to a point near the ground, below the vertical center of gravity of the user and between the lifter's feet. There is significant biomechanical advantage to this load configuration. One person can carry heavy, awkward loads safely and quickly with a minimum of physical stress.