The invention discloses a bottom power taking self-locking electric bus battery box system capable of quickly changing a battery. The system comprises a battery box (1), a tray (2) used for bearing the battery box and arranged on an electric bus, mobile equipment (4) for conveying the battery box, and a grabbing device (5) arranged on the mobile equipment; and a battery box locking and unlocking device (3) is arranged on the tray. Through the system, automatic assembly of the battery box in the electric bus battery box system is realized, and the problems of over positioning, deformation of power wire connection pegs, breakage, arc discharge, welding, difficulty in automatically realizing unlocking due to impact of the battery box to a bolt of a locking mechanism in jolt and deformation of the battery box due to impact in jolt. The system is reasonable, reliable, simple and compact in structure, and can full-automatically, quickly and conveniently realize quick change of the power battery.