A humidification
system can include a heater base, a humidification chamber, and a
breathing circuit. A
cartridge can be removably coupled to the heater base. The
cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and / or other features. The
cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an
EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and / or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers,
breathing circuits, and / or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an
electrical connection to the cartridge.