25 results about "Immune dysregulation" patented technology

The invention discloses a black phosphorus hydrogel microneedle patch loaded with trained mesenchymal stem cells as well as a preparation method and application of the black phosphorus hydrogel microneedle patch, and belongs to the technical field of biological medicines. The micro-needle patch comprises a hydrogel substrate layer loaded with black phosphorus nanosheets and a hydrogel needle tip part for packaging the stem cells. The mesenchymal stem cells are subjected to combined domestication with low oxygen and high active oxygen, so that the anti-oxidative stress, anti-inflammatory and angiogenesis promoting capabilities of the mesenchymal stem cells are remarkably enhanced. After the patch is subcutaneously delivered, the black phosphorus component can efficiently remove bacteria and reduce drug resistance; after being domesticated, the stem cells can adapt to the immune microenvironment of the wound surface, and the immune regulation, inflammation inhibition and tissue regeneration promotion are synergistically realized by continuously releasing anti-inflammatory and angiogenesis promoting factors, so that the refractory wound surface caused by immune disorders such as systemic lupus erythematosus (SLE) and the like is effectively treated. The invention provides an innovative treatment strategy for chronic inflammatory wound healing.

The application discloses CpG-containing oligodeoxynucleotide (ODN) with the function of regulating the body's immune capacity and application thereof. The oligodeoxynucleotide in the application is different from the design concept of traditional A-type CpG ODN in sequence and structure, embodies the complex drug-making rule and overcomes the problem of traditional A-type CPG in drug-making. The oligodeoxynucleotide has excellent activity of regulating the body's immune function in vitro and in vivo, can stimulate the production of I, II and III type interferons, regulates the Th1 type immune response, and inhibits the Th2 type and Th17 type inflammatory response. Therefore, the oligodeoxynucleotide can prevent and treat allergic diseases caused by Th2 type immune response, including allergic rhinitis, atopic dermatitis, asthma, chronic obstructive pulmonary disease, eosinophil and Th17 related diseases, can prevent and treat the infection and spread of respiratory or non-respiratory pathogenic microorganisms including viruses, bacteria, fungi and parasites, can improve the immune level of the elderly and immunodeficient population, can convert "cold tumor" into "hot tumor", improve the effect of cancer immunotherapy, can prevent and treat central nervous system diseases related to immune dysfunction such as Alzheimer's disease, and can be applied to other diseases related to immune dysfunction.

The invention belongs to the field of food, particularly relates to a nutritional composition and application thereof in improving immune disorder, and more particularly relates to application of the nutritional composition in preparing food for improving filial generation body inflammatory factor level disorder caused by maternal immune activation. The nutritional composition comprises essential active ingredients shown as the following (i) and (ii): (i) a neutral fucosylated breast milk oligosaccharide, (ii) a neutral non-fucosylated breast milk oligosaccharide; wherein the neutral fucosylated breast milk oligosaccharide at least comprises 2 '-fucosylated lactose, and the neutral non-fucosylated breast milk oligosaccharide at least comprises lactose-N-neotetraose; in addition, in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 2 '-fucosyllactose is 1: (1-8), and the 2'-fucosyllactose and the lactose-N-neotetraose can achieve a synergistic effect to regulate filial generation immunity.

This invention discloses a class of pyrazolopyridine compounds linked by an aza-four-membered ring, or pharmaceutically acceptable salts thereof, and their applications. These compounds can serve as novel, highly selective PDE10A inhibitors for the treatment of peripheral tissue diseases, including: myocardial hypertrophy and cardiac dysfunction (heart failure), diabetes, hypertension, renal impairment and renal fibrosis, pulmonary inflammation and pulmonary fibrosis, immune dysregulation, and cancers (colon cancer, ovarian cancer, and lung cancer). Two strategies are employed to achieve high selectivity for PDE10A inhibition while simultaneously reducing the inhibitory effect on the central nervous system. First, molecular structure modification: structural optimization of the aza-four-membered ring-linked pyrazolopyridine compounds, such as increasing the ratio of N, O, and S atoms in the molecular structure to increase the polar surface area and reduce lipophilicity; and introducing hydrophilic groups to increase water solubility, thereby reducing the permeability of the compound to the blood-brain barrier (BBB). Second, targeted drug delivery to lung tissue via pharmaceutical formulation.

The invention relates to a gene-edited cytotoxic cell comprising a chimeric antigen receptor (CAR) that binds CD30, for use in the treatment of an infection, in which infected cells express CD30. In embodiments, the treatment comprises the cytotoxic cell binding to a human target cell, which is infected with a chronic inflammatory virus and expresses CD30. In embodiments, the treatment comprises cytotoxic activity against a reservoir of infected human CD30-expressing target cells in a subject with a chronic viral infection with associated pathologies, immune dysregulations and autoimmune diseases. Corresponding medical uses and methods of treatment are encompassed by the present invention. In another aspect, the invention relates to the CD30-CAR-expressing gene-edited cytotoxic cell as described herein. In other aspects, the invention relates to the CD30-CAR nucleic acid construct and the CAR polypeptide as described herein.

The invention relates to the technical field of molecular biology, in particular to application of RIPK3 gene mutation as a detection target and a detection reagent. An experiment shows that an individual with heterozygote RIPK3 mutation (c.400Cgt; A, p.Gln134Lys) shows the symptom of a Still disease sample self-inflammatory disease, and a potential relation exists between the variation and immune disorder, and is characterized in that necroptosis sensitivity is increased and an inflammatory signal is amplified, so that a pro-inflammatory environment is caused. According to the invention, the relation between RIPK3 variation and the expression of the self-inflammatory disease of the Stetier disease sample is established, the understanding of people on the molecular basis of the self-inflammatory disease of the Stetier disease sample is expanded, and the importance of RIPK3 in human immune homeostasis is emphasized.

The present disclosure provides anti-TIGIT polypeptides or fragments thereof. Further provided are methods of using the antibodies or fragments thereof for the treatment and diagnosis of diseases, such as cancer, infection, or immune disorders.

This invention provides multiple oligodeoxyribonucleotides (ODNs), including CpGs, that have the function of modulating the immune system of organisms, and their uses. These oligodeoxyribonucleotides differ in sequence and structure from the design concepts of conventional type A CpG ODNs, demonstrating complex drug discovery rules and solving the challenges of conventional type A CpG drug discovery. They exhibit excellent activity in modulating the immune function of organisms both in vitro and in vivo, stimulating the production of type I, II, and III interferons, enhancing the Th1 immune response, and suppressing Th2 and Th17 inflammatory responses. Therefore, they can prevent and treat allergic diseases caused by Th2 immune responses, such as allergic rhinitis, atopic dermatitis, asthma, chronic obstructive pulmonary disease, eosinophilic granulocyte and Th17-related diseases, prevent and treat infection and transmission of respiratory or non-respiratory pathogenic microorganisms such as viruses, bacteria, fungi, and parasites, and improve immune levels in elderly and immunocompromised populations. It can transform "cold tumors" into "hot tumors," improve the effectiveness of cancer immunotherapy, prevent and treat central nervous system diseases associated with immune dysregulation such as Alzheimer's disease, and can also be used for other diseases associated with immune dysregulation.

This invention belongs to the field of biomedical technology, specifically relating to an umbilical cord MSC exosome nanocarrier delivery system and its application in the preparation of drugs for treating allergic rhinitis. This invention prepares the umbilical cord MSC exosome nanocarrier delivery system by adding a specific concentration of diosgenin to the culture medium of umbilical cord mesenchymal stromal cells (MSCs), collecting the cell culture supernatant, and separating and extracting it. Animal experiments show that the delivery system prepared in this invention significantly improves the symptoms of nose scratching and sneezing in mice with allergic rhinitis. Its mechanism of action lies in effectively regulating the Th1 / Th2 immune balance: significantly inhibiting the overexpression of the pro-inflammatory factor IL-4, while simultaneously restoring the anti-inflammatory factor IL-10, thus avoiding immune dysregulation. This invention provides a safe and effective new treatment for allergic rhinitis and has good clinical application prospects.

The present application belongs to the field of food, and particularly relates to a nutritional composition and its use for improving immune disorders, more particularly to the use of a nutritional composition in the preparation of a food for improving the level disorder of inflammatory factors in offspring caused by maternal immune activation; the nutritional composition comprises essential active ingredients shown as (i) and (ii): (i) neutral fucosylated human milk oligosaccharides, (ii) neutral non-fucosylated human milk oligosaccharides; wherein the neutral fucosylated human milk oligosaccharides at least comprise 2'-fucosyllactose, and the neutral non-fucosylated human milk oligosaccharides at least comprise lacto-N-neotetraose; and in the nutritional composition, the mass ratio of the lacto-N-neotetraose to the 2'-fucosyllactose is 1:(1-8). 2'-fucosyllactose and lacto-N-neotetraose can synergistically regulate offspring immunity.

The invention discloses a Yifang polypeptide composition as well as a preparation method and application thereof, and belongs to the technical field of compositions. The beneficial formula polypeptide composition comprises a probiotic mixture, a prebiotic mixture and a polypeptide mixture. The composition capable of achieving a multi-target synergistic effect is constructed by scientifically compounding probiotics, prebiotics and various active polypeptides, so that the intestinal flora balance can be adjusted, the release of inflammatory factors can be inhibited through the biological activity of the polypeptides, the intestinal barrier function is repaired, and the intestinal health is improved. Therefore, the problems of gastrointestinal dysfunction, skin symptoms, immune disorder and the like caused by intestinal problems are fundamentally improved, and a more comprehensive and efficient solution is provided for solving complex intestinal health problems.

This invention discloses an 8–18 nm covalently bonded pH-responsive biomass active pharmaceutical ingredient (API), its preparation method, and its applications. The API has a three-layer covalently bonded core-shell structure, is free of free small molecules, and exhibits excellent structural stability. It is prepared from bamboo-derived biomass raw materials such as modified bile acid-bamboo flavonoid cocrystal complex, modified bamboo polysaccharides, and galactose oligosaccharides. The product has a particle size of 8–18 nm, a PDI < 0.21, a Zeta potential of -8.0 to -11.0 mV, and possesses pH-targeted drug release characteristics within the renal lesion microenvironment. Under normal physiological conditions, the drug leakage rate is less than 3.2%, and the in vivo biodegradation rate exceeds 99.1% within 72 hours. It exhibits no tissue accumulation and high safety. This invention targets the common pathological features of renal oxidative stress, chronic inflammation, and immune dysregulation in viral renal failure and renal cancer, exerting therapeutic effects through antioxidant, anti-inflammatory, renal tubular barrier repair, and immune regulation mechanisms. This invention employs a room-temperature pure aqueous phase reaction combined with a two-stage ultrafiltration process, ensuring mild conditions, batch stability, and suitability for industrial mass production.

The present application relates to the use of pyrazolopyrimidine compounds of general formula (I). The compounds are effective in inhibiting the activity of CD73 and have good application prospects as CD73 small molecule inhibitors in the treatment and / or prevention of CD73-related diseases, disorders and conditions, particularly cancer and immune disorders.

This application relates to the pharmaceutical field, and specifically to a multi-TRP ion channel modulator, its preparation method, and its application. The multi-TRP ion channel modulator developed in this application can inhibit TRPV1, activate TRPM8, and activate TRPA1, and can be used to treat functional gastrointestinal disorders, intestinal mucosal damage, intestinal inflammation, immune dysregulation, gut microbiota imbalance, gastrointestinal tumors, pain, or peripheral neuritis.

The present invention provides novel small-molecule compounds with tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) inhibitory properties, intended for oral administration in the treatment of inflammatory and autoimmune diseases, such as psoriasis and rheumatoid arthritis. These compounds selectively inhibit TNF-α and IL-17, key cytokines implicated in chronic inflammation and immune dysregulation. The compounds of this invention overcome these limitations by offering an orally administrable, cost-effective alternative with high specificity and reduced toxicity. The synthetic methods for preparing the compounds, as well as pharmaceutical formulations are also disclosed.

The invention relates to the field of medicine, in particular to a multi-TRP ion channel regulator and a preparation method and application thereof. The multi-TRP ion channel regulator researched and developed in the invention can inhibit TRPV1, activate TRPM8 and activate TRPA1, and is used for treating functional gastrointestinal diseases, intestinal mucosa injury, intestinal inflammation, immune disorder, dysbacteriosis, digestive tract tumors, pain or peripheral neuritis.

The present invention relates to novel pharmaceutical agents and the process of preparation thereof. The present invention discloses compounds of general formula I, and the process of their preparation. The compounds of the invention are useful in the treatment and prevention of diseases related to cellular stress mediated immune deregulation and loss of homeostasis also including autoimmune diseases, cancers, metabolic, dermatological, cardiovascular and neurodegenerative diseases.

The invention discloses application of taurine in inhibition of excessive inflammatory response of sepsis, and relates to the technical field of biological medicines. The invention relates to application of taurine or pharmaceutically acceptable salt thereof in preparation of drugs for improving sepsis metabolic disorder, the improvement of the sepsis metabolic disorder comprises up-regulation of the taurine level in a sepsis individual, and the improvement of the sepsis metabolic disorder comprises adjustment of the immune phenotype of macrophages, inhibition of phenotype polarization of macrophages to pro-inflammatory M1, reduction of the immune phenotype of macrophages, reduction of the immune phenotype of macrophages, reduction of the immune phenotype of macrophages, reduction of the immune phenotype of macrophages, reduction of the immune phenotype of macrophages, reduction of The medicine can reduce the level of pro-inflammatory cytokines in serum of sepsis individuals. The invention provides and verifies that taurine plays a role by regulating the immunophenotype of macrophages; the application directly aims at a core pathological link of early immune disorder of sepsis and inflammatory storm instead of simply inhibiting inflammation in a broad spectrum, and is expected to realize more accurate and safer treatment.

Idiopathic Parkinson's disease (iPD) is a multi-system disorder, and the debilitating motor stage of iPD can be preceded for years by a prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder (RBD) and gastrointestinal symptoms. Widespread immune dysregulation has been reported in clinically diagnosed iPD, but the existence of immune deficits during the prodromal stage has yet to be thoroughly investigated. Here, it was shown that multiple stages of iPD, including the pre-motor prodromal stage, can be stratified according to the immuno-metabolic response to stimulation of peripheral blood immune cells ex vivo. Peripheral blood monocytes from RBD patients displayed increased stimulation-dependent secretion of inflammatory cytokines, including TNF, IL-1β, and IL-8, which peaks in the prodromal stage and successively diminishes as PD progresses. Furthermore, T lymphocyte mitochondrial health was correlated with stimulation-evoked cytokine secretion across patients with RBD, early-stage iPD, and moderate-stage iPD. The results disclosed here have broad implications for mechanistic understanding of how peripheral inflammation may drive disease progression, and it reveals novel biomarkers to enable patient stratification and progression monitoring for clinical trials based on immune endophenotypes.

The invention belongs to the field of food, particularly relates to a nutritional composition and application thereof in improving immune disorder, and more particularly relates to application of the nutritional composition in preparing food for improving filial generation body inflammatory factor level disorder caused by maternal immune activation. The nutritional composition comprises essential active ingredients shown as the following (i) and (ii): (i) a neutral fucosylated breast milk oligosaccharide, (ii) a neutral non-fucosylated breast milk oligosaccharide; wherein the neutral fucosylated breast milk oligosaccharide at least comprises 2 '-fucosylated lactose, and the neutral non-fucosylated breast milk oligosaccharide at least comprises lactose-N-neotetraose; in addition, in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 2 '-fucosyllactose is 1: (1-8), and the 2'-fucosyllactose and the lactose-N-neotetraose can achieve a synergistic effect to regulate filial generation immunity.

The invention relates to the technical field of biological medicines, in particular to a pharmaceutical composition as well as a preparation method and application thereof. The invention provides an anti-inflammatory pharmaceutical composition containing budesonide (derivative) and bortezomib, the pharmaceutical curative effect is remarkably improved by utilizing a synergistic effect, an accumulative effect and an enhancement effect caused by drug combination, the immune disorder microenvironment and the immune macroenvironment are improved at the same time, and when the anti-inflammatory pharmaceutical composition is used for anti-inflammatory treatment of various diseases, the anti-inflammatory effect is obviously improved. The traditional Chinese medicine composition has an excellent anti-inflammatory effect and can effectively delay relapse.

Central Serous chorioretinopathy (CSCR) is primarily an ocular disease, affecting the choroid and the retinal pigment epithelium. To date, no systemic biomarker of CSCR have been discovered that could link both forms and help the diagnosis in challenging cases. In the present invention, the inventors measure in European cohorts of CSCR patients (n=168) with (n=90) or without epitheliopathy (n=78) and a cohort of 153 control subjects without any ocular disease history, the serum levels of NGAL and the NGAL / MMP9 complex. Serum NGAL (ng / ml) was significantly higher in the control group (108.8±46.8) than in the CSCR cohort (80.4±46.4, p<0.0001). Serum NGAL (ng / ml) was significantly lower in the acute / recurrent cohort (n=78, 71.3±32.1) than in the control and, than in the chronic cohort (n=90, 88.3±55, p=0.03). Similarly, Serum NGAL / MMP9 (ng / ml) levels was lower in the whole CSCR cohort (44.5±39.6) as compared to the controls (77.6±47.8, p<0.0001). Serum NGAL / MMP9 (ng / ml) were significantly lower in the acute / recurrent cohort (37.6±37.9) than in the control and, than in the chronic cohort (50.5±40.3, p=0.002). Thus, in both forms of CSCR serum NGAL and NGAL / MMP9 are lower than in the control population, providing a biological link between the two forms and a potential susceptibility to oxidative stress and innate immune dysregulation. Systemic LCN2 being elevated in other retinal diseases, it represents a specific biomarker for CSCR.

The invention relates to a gene-edited cytotoxic cell comprising a chimeric antigen receptor (CAR) that binds CD30, for use in the treatment of an infection, in which infected cells express CD30. In embodiments, the treatment comprises the cytotoxic cell binding to a human target cell, which is infected with a chronic inflammatory virus and expresses CD30. In embodiments, the treatment comprises cytotoxic activity against a reservoir of infected human CD30-expressing target cells in a subject with a chronic viral infection with associated pathologies, immune dysregulations and autoimmune diseases. Corresponding medical uses and methods of treatment are encompassed by the present invention. In another aspect, the invention relates to the CD30-CAR-expressing gene-edited cytotoxic cell as described herein. In other aspects, the invention relates to the CD30-CAR nucleic acid construct and the CAR polypeptide as described herein.

The invention provides application of achyranthes bidentata polysaccharides and a pharmaceutical composition containing the achyranthes bidentata polysaccharides in preparation of medicines for treating secondary seasonal influenza of diabetes mellitus. According to the invention, the achyranthes bidentata polysaccharide has blood glucose reducing, immunoregulation and antiviral activities, and aiming at the complex pathology that metabolic disorder and immune disorder coexist in diabetes secondary influenza, the synergistic intervention is realized, and the traditional Chinese medicine composition has more potential advantages than a single antiviral medicine or a blood glucose reducing medicine. The medicine has the advantages of definite curative effect and multi-target point coordination, and has a good clinical application prospect.

Provided herein are peptide-based therapeutics that target POXP3 and methods of use thereof to decrease the immunosuppressive effects of Tregs and inhibit immune dysregulation, while sparring inhibition of activated cytotoxic T cells, for example, in the context of anti-tumor immune responses, autoimmunity, inflammatory conditions, etc.