50 results about "NK cell proliferation" patented technology

Methods of ex-vivo culture of natural killer (NK) cells are provided and, more particularly, methods for enhancing propagation and / or functionality of NK cells by treating the cells with an aryl hydrocarbon antagonist in combination with cytokines driving NK cell proliferation. Also envisioned are compositions comprising cultured NK cells and therapeutic uses thereof.

The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

The invention discloses double-open-loop derivatives and preparation methods of cyperapuinone and analogues and application in CIK cell culture. It is found in the invention that the cyperapuinone andits analogues demethylcyperapuinone and hydroxycyperapuinone have multiple types of pharmacological activity, for example, the cyperapuinone and its analogues can serve as cryoprotective agents for CIK and NK cells and can promote in-vitro proliferation of the CIK and NK cells and promote osteogenesis and differentiation of adipose-derived stem cells. The invention also provides single-open-loopderivatives and double-open-loop derivatives and preparation methods of the cyperapuinone and its analogues. The single-open-loop derivatives and double-open-loop derivatives of the cyperapuinone andits analogues can promote in-vitro proliferation of the CIK cells. It is found through retrieval that the application of the cyperapuinone and its analogues in promotion of CIK and NK cell proliferation and osteogenesis and differentiation of adipose-derived stem cells is not disclosed in the prior art and single-furan-ring derivatives and double-furan-ring open-ring derivatives of the cyperapuinone and its analogues is also not reported.